Chinese Guideline for the Diagnosis and Management of Drug-Induced Liver Injury in Primary Care (2024)
Yi Min Mao , Jie Ting Tang , Zhong Hua Lu , Ming Shao , Wei Feng Zhao , Jun Zhan , Zu Xiong Huang , Qing Hui Niu , Lin Chen , Zhan Feng Chen , Chun Hui Guo , Zi Hui Jia , Hai Li , Bo Liu , Jing Miao , Zhong Tian Peng , Yong Lan Pu , Li Hong Qu , Xiao Ming Shen , Wei Sun , Hong Wu Wang , Xiao Lan Lu , Jian Jun Xue , Ya Yun Yang , Zheng Yang , Zhong Hui Yang , Qing Ge Zhang , Tao Niu , Wei Dong Zhu , Xiao Lin Liu , Wei Zhong , Yi Nuo Dong , Yang Zhi , Xiao Yun Li
Journal of Digestive Diseases ›› 2025, Vol. 26 ›› Issue (1-2) : 2 -21.
Chinese Guideline for the Diagnosis and Management of Drug-Induced Liver Injury in Primary Care (2024)
Drug-induced liver injury (DILI) is a drug-induced disease that not only complicates the treatment of the primary disease but may also lead to acute liver failure or even death in severe cases. Drugs commonly used in primary care, such as anti-infective agents and nonsteroidal anti-inflammatory drugs, are major causes of DILI. In addition, a large elderly population, comorbidities, and combination therapy with multiple drugs increase the risk of DILI in primary care. Therefore, primary care providers should proactively screen and monitor high-risk patients to identify potential DILI timely. Currently, diagnosis of DILI relies on the exclusion of liver diseases of other etiologies. Collection of detailed medical history of the patients and careful exclusion of other potential liver injury of other etiologies are crucial for accurate diagnosis. This guideline, developed based on evidence-based medicine from the latest research, aimed to provide primary care providers with professional guidance on the timely identification of suspected DILI cases and standardized diagnosis and management in clinical practice.
diagnosis / drug-induced liver injury / guidelines / primary care / treatment
2025 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
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