Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

Yi Jin; Frederick Clasen; Fernando Garcia-Guevara; Sania Arif; Robert Schierwagen; Gholamreza Bidkhori; Michael Praktiknjo; Maximilian J. Brol; Frank E. Uschner; Florence A. Castelli; Nicolas Pons; Benoit Quinquis; Nathalie Galleron; Kevin Da Silva; Christophe Junot; Debbie L. Shawcross; David L. Moyes; Rajiv Jalan; S. Dusko Ehrlich; Vishal C. Patel; Jonel Trebicka; Saeed Shoaie

doi:10.1002/imt2.70131

iMeta ›› 2026, Vol. 5 ›› Issue (3) :e70131 DOI: 10.1002/imt2.70131

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Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

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¹. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK

². Department of Internal Medicine B, University of Münster, Münster, Germany

³. CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), MetaboHUB-IDF, Université Paris-Saclay, Gif-sur-Yvette, France

⁴. Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France

⁵. Roger Williams Institute of Liver Studies, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK

⁶. Liver Failure Group, UCL Institute for Liver and Digestive Health, London, UK

⁷. European Foundation for the Study of Chronic Liver Failure, EF CLIF, Barcelona, Spain

⁸. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK

⁹. Department of Medical Gastroenterology and Hepatology, University of Southern Denmark, Odense, Denmark

¹⁰. Quantitative Systems Biology, Faculty of Medicine, Biruni University, Istanbul, Turkey

saeed.shoaie@kcl.ac.uk

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Yi Jin, Frederick Clasen, Fernando Garcia-Guevara, Sania Arif, Robert Schierwagen, Gholamreza Bidkhori, Michael Praktiknjo, Maximilian J. Brol, Frank E. Uschner, Florence A. Castelli, Nicolas Pons, Benoit Quinquis, Nathalie Galleron, Kevin Da Silva, Christophe Junot, Debbie L. Shawcross, David L. Moyes, Rajiv Jalan, S. Dusko Ehrlich, Vishal C. Patel, Jonel Trebicka, Saeed Shoaie. Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis. iMeta, 2026, 5 (3) : e70131 DOI:10.1002/imt2.70131

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