Nano-plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

Yi Zhang , Zheng Lin , Runtong Huang , Yang Zhang , Lei Wang , Zan Fu , Chao Wang , Shuai Xiao , Heru Pramono , Kui Xu , Zhimin Xu , Yulong Yin

iMeta ›› 2026, Vol. 5 ›› Issue (1) : e70103

PDF (1812KB)
iMeta ›› 2026, Vol. 5 ›› Issue (1) :e70103 DOI: 10.1002/imt2.70103
CORRESPONDENCE
Nano-plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction
Author information +
History +
PDF (1812KB)

Cite this article

Download citation ▾
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin. Nano-plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction. iMeta, 2026, 5 (1) : e70103 DOI:10.1002/imt2.70103

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Thompson, Richard C., Winnie Courtene-Jones, Julien Boucher, Sabine Pahl, Karen Raubenheimer, and Albert A. Koelmans. 2024. “Twenty Years of Microplastic Pollution Research—What Have We Learned?” Science 386: eadl2746. https://doi.org/10.1126/science.adl2746

[2]

Deng, Yanhong, Zhiming Li, Yuji Huang, Yizhou Zhong, Aiqin Qiu, Xiaoqing Chen, Xiyun Huang, et al. 2025. “Hepatotoxicity Induced by Polylactic Acid Microplastics: the Mediating Role of Gut Microbiota and Uric Acid Metabolism.” Journal of Advanced Research 25: 00661-7. https://doi.org/10.1016/j.jare.2025.08.055

[3]

Xu, Zhimin, Jiemiao Shen, Lihong Lin, Jieting Chen, Lei Wang, Xingying Deng, Xinyue Wu, et al. 2023. “Exposure to Irregular Microplastic Shed from Baby Bottles Activates the Ros/Nlrp3/Caspase-1 Signaling Pathway, Causing Intestinal Inflammation.” Environment International 181: 108296. https://doi.org/10.1016/j.envint.2023.108296

[4]

Zha, Hua, Shengjie Li, Aoxiang Zhuge, Jian Shen, Yuanyuan Yao, Kevin Chang, and Lanjuan Li. 2025. “Hazard Assessment of Airborne and Foodborne Biodegradable Polyhydroxyalkanoates Microplastics and Non-Biodegradable Polypropylene Microplastics.” Environment International 196: 109311. https://doi.org/10.1016/j.envint.2025.109311

[5]

Ma, Qianwen, Yanting Jialin Lei, Yu Pang, Ting Shen, and Zhang. 2025. “Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts.” Environment & Health 3: 831. https://doi.org/10.1021/envhealth.5c00087

[6]

Shruti, V. C., Gurusamy Kutralam-Muniasamy, Fermín Pérez-Guevara, and Ricardo Cuenca Alvarez. 2025. “Exploring the Micro- and Nanoplastics–Diabetes Nexus: Shattered Barriers, Toxic Links, and Methodological Horizons.” Environmental Pollution 375: 126319. https://doi.org/10.1016/j.envpol.2025.126319

[7]

Xu, Zhimin, Yuxue Zhang, Zhihao Xu, Yuming Zhong, Lei Wang, Chunguang Liu, Ailing Chen, et al. 2023. “Dysregulation of Gut Health in Zebrafish by Differentially Charged Nanoplastic Exposure: an Integrated Analysis of Histopathology, Immunology, and Microbial Informatics.” Environmental Science: Nano 10: 933–47. https://doi.org/10.1039/D2EN00542E

[8]

Ji, Yunxia, Libang Chen, Yunqing Wang, Jinjin Zhang, Yue Yu, Meirong Wang, Xiaoyan Wang, et al. 2024. “Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction.” ACS Nano 18: 16790–807. https://doi.org/10.1021/acsnano.4c02335

[9]

Cortese-Krott, Miriam M., Friederike Cuello, Jan R. Kraehling, and Michael Russwurm. 2025. “The 11th International Conference on Cgmp 2024: Recent Trends and Developments in Cgmp Research—Meeting Report.” Naunyn-Schmiedeberg's Archives of Pharmacology 398: 12789–805. https://doi.org/10.1007/s00210-025-04059-1

[10]

Régnier, Marion, Thaïs Carbinatti, Lucia Parlati, Fadila Benhamed, and Catherine Postic. 2023. “The Role of Chrebp in Carbohydrate Sensing and Nafld Development.” Nature Reviews Endocrinology 19: 336–49. https://doi.org/10.1038/s41574-023-00809-4

[11]

Cheng, Yixian, Junjie Chen, Rui Fu, Peng Zhang, Haosong Chen, Haikun Cao, Zilong Jiang, et al. 2025. “Molecular Mechanism Differences between Nanoplastics and Microplastics in Colon Toxicity: Nanoplastics Induce Ferroptosis-Mediated Immunogenic Cell Death, While Microplastics Cause Cell Metabolic Reprogramming.” Journal of Nanobiotechnology 23: 505. https://doi.org/10.1186/s12951-025-03545-1

[12]

Wen, Jing, Bingwei Hang Sun, Erqun Yang, Yang Song, Guibin Song, and Jiang. 2024. “Environmentally Relevant Concentrations of Microplastic Exposure Cause Cholestasis and Bile Acid Metabolism Dysregulation through a Gut-Liver Loop in Mice.” Environmental Science & Technology 58: 1832–41. https://doi.org/10.1021/acs.est.3c07108

[13]

Zhang, Zhaoqiang, Zepeng Su, Zhikun Li, Jinteng Li, Wenhui Yu, Guiwen Ye, Jiajie Lin, et al. 2024. “Cyp7b1-Mediated 25-Hydroxycholesterol Degradation Maintains Quiescence-Activation Balance and Improves Therapeutic Potential of Mesenchymal Stem Cells.” Cell Chemical Biology 31: 1277–89. https://doi.org/10.1016/j.chembiol.2024.01.009

[14]

Ridlon, Jason M., and H. Rex Gaskins. 2024. “Another Renaissance for Bile Acid Gastrointestinal Microbiology.” Nature Reviews Gastroenterology & Hepatology 21: 348–64. https://doi.org/10.1038/s41575-024-00896-2

[15]

He, Chengxun, Peipei Wang, Yuanyuan Zuo, Juan Guo, Qing Zhang, Shuyang Peng, Hong Zhang, et al. 2025. “Constituents-Composed Chinese Medicine of Dajianzhong Decoction Ameliorates Non-Alcoholic Fatty Liver Disease Via Ampk/Pparα/Cpt1 Signaling.” Phytomedicine 149: 157515. https://doi.org/10.1016/j.phymed.2025.157515

[16]

Lee, Michael H., Sean-Paul Nuccio, Ipsita Mohanty, Lee, Lee R. Hagey, Pieter C. Dorrestein, Hiutung Chu, and Manuela Raffatellu. 2024. “How Bile Acids and the Microbiota Interact to Shape Host Immunity.” Nature Reviews Immunology 24: 798–809. https://doi.org/10.1038/s41577-024-01057-x

[17]

Mukherjee, Tapas, Naveen Kumar, Meenakshi Chawla, Dana J. Philpott, and Soumen Basak. 2024. “The Nf-Κb Signaling System in the Immunopathogenesis of Inflammatory Bowel Disease.” Science Signaling 17: eadh1641. https://doi.org/10.1126/scisignal.adh1641

[18]

Tugizov, Sharof. 2021. “Virus-Associated Disruption of Mucosal Epithelial Tight Junctions and Its Role in Viral Transmission and Spread.” Tissue Barriers 9: 1943274. https://doi.org/10.1080/21688370.2021.1943274

[19]

Li, Nengneng, Yue Li, Ziyu Huang, Zhirui Cao, Cha Cao, Xiang Gao, and Tao Zuo. 2025. “Faecal Phageome Transplantation Alleviates Intermittent Intestinal Inflammation in Ibd and the Timing of Transplantation Matters: A Preclinical Proof-of-Concept Study in Mice.” Gut 74: 868–70. https://doi.org/10.1136/gutjnl-2024-333598

[20]

Xu, Xinming, Qingying Feng, Tao Zhang, Yunlong Gao, Qu Cheng, Wanqiu Zhang, Qinglong Wu, et al. 2024. “Infant Age Inversely Correlates with Gut Carriage of Resistance Genes, Reflecting Modifications in Microbial Carbohydrate Metabolism During Early Life.” iMeta 3: e169. https://doi.org/10.1002/imt2.169

RIGHTS & PERMISSIONS

2025 The Author(s). iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.

PDF (1812KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/