Host-driven hepatic conversion of gut microbiota-derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish

References

[1] Schoeler, Marc, Sandrine Ellero-Simatos, Till Birkner, Jordi Mayneris-Perxachs, Lisa Olsson, Harald Brolin, Ulrike Loeber, et al. 2023. “The Interplay between Dietary Fatty Acids and Gut Microbiota Influences Host Metabolism and Hepatic Steatosis.” Nature Communications 14(1): 5329. https://doi.org/10.1038/s41467-023-41074-3

[2] Tan, Shuai, Jacobo L. Santolaya, Tiffany Freeney Wright, Qi Liu, Teppei Fujikawa, Sensen Chi, Colin P. Bergstrom, et al. 2024. “Interaction between the Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism.” Nature Metabolism 6(6): 1076–91. https://doi.org/10.1038/s42255-024-01044-5

[3] Hill, Jennifer Hampton, Michelle Sconce Massaquoi, Emily Goers Sweeney, Elena S. Wall, Philip Jahl, Rickesha Bell, Karen Kallio, et al. 2022. “Befa, a Microbiota-Secreted Membrane Disrupter, Disseminates to the Pancreas and Increases β Cell Mass.” Cell Metabolism 34(11): 1779–91.e9. https://doi.org/10.1016/j.cmet.2022.09.001

[4] Bae, Munhyung, Chelsi D. Cassilly, Xiaoxi Liu, Sung-Moo Park, Betsabeh Khoramian Tusi, Xiangjun Chen, Jaeyoung Kwon, et al. 2022. “Akkermansia muciniphila Phospholipid Induces Homeostatic Immune Responses.” Nature 608(7921): 168–73. https://doi.org/10.1038/s41586-022-04985-7

[5] Le, Henry H., Min-Ting Lee, Kevin R. Besler, and Elizabeth L. Johnson. 2022. “Host Hepatic Metabolism Is Modulated by Gut Microbiota-Derived Sphingolipids.” Cell Host & Microbe 30(6): 798–808. https://doi.org/10.1016/j.chom.2022.05.002

[6] Jugder, Bat-Erdene, Layla Kamareddine, and Paula I. Watnick. 2021. “Microbiota-Derived Acetate Activates Intestinal Innate Immunity Via the tip60 Histone Acetyltransferase Complex.” Immunity 54(8): 1683–97.e3. https://doi.org/10.1016/j.immuni.2021.05.017

[7] Winston, Jenessa A., and Casey M. Theriot. 2019. “Diversification of Host Bile Acids by Members of the Gut Microbiota.” Gut Microbes 11(2): 158–71. https://doi.org/10.1080/19490976.2019.1674124

[8] Agus, Allison, Julien Planchais, and Harry Sokol. 2018. “Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.” Cell Host & Microbe 23(6): 716–24. https://doi.org/10.1016/j.chom.2018.05.003

[9] Albillos, Agustín, Andrea de Gottardi, and María Rescigno. 2020. “The Gut-Liver Axis in Liver Disease: Pathophysiological Basis for Therapy.” Journal of Hepatology 72(3): 558–77. https://doi.org/10.1016/j.jhep.2019.10.003

[10] Nie, Qixing, Xi Luo, Kai Wang, Yong Ding, Shumi Jia, Qixiang Zhao, Meng Li, et al. 2024. “Gut Symbionts Alleviate Mash Through a Secondary Bile Acid Biosynthetic Pathway.” Cell 187(11): 2717–34.e33. https://doi.org/10.1016/j.cell.2024.03.034

[11] Hsu, Cynthia L., and Bernd Schnabl. 2023. “The Gut–Liver Axis and Gut Microbiota in Health and Liver Disease.” Nature Reviews Microbiology 21(11): 719–33. https://doi.org/10.1038/s41579-023-00904-3

[12] Li, Hu, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, et al. 2024. “Bacteroides thetaiotaomicron Ameliorates Mouse Hepatic Steatosis Through Regulating Gut Microbial Composition, Gut-liver Folate and Unsaturated Fatty Acids Metabolism.” Gut Microbes 16(1), 2304159. https://doi.org/10.1080/19490976.2024.2304159

[13] Wang, Zeneng, Elizabeth Klipfell, Brian J. Bennett, Robert Koeth, Bruce S. Levison, Brandon DuGar, Ariel E. Feldstein, et al. 2011. “Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease.” Nature 472(7341): 57–63. https://doi.org/10.1038/nature09922

[14] Sharma, Vandana, Jamie Smolin, Jonamani Nayak, Julio E. Ayala, David A. Scott, Scott N. Peterson, and Hudson H. Freeze. 2018. “Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism.” Cell Reports 24(12): 3087–98. https://doi.org/10.1016/j.celrep.2018.08.064

[15] Kitada, Yusuke, Koji Muramatsu, Hirokazu Toju, Ryoko Kibe, Yoshimi Benno, Shin Kurihara, and Mitsuharu Matsumoto. 2018. “Bioactive Polyamine Production by a Novel Hybrid System Comprising Multiple Indigenous Gut Bacterial Strategies.” Science Advances 4(6), eaat0062. https://doi.org/10.1126/sciadv.aat0062

[16] Madeo, Frank, Tobias Eisenberg, Federico Pietrocola, and Guido Kroemer. 2018. “Spermidine in Health and Disease.” Science 359(6374), eaan2788. https://doi.org/10.1126/science.aan2788

[17] Zhou, Jin, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, et al. 2022. “Spermidine-Mediated Hypusination of Translation Factor eif5a Improves Mitochondrial Fatty Acid Oxidation and Prevents Non-Alcoholic Steatohepatitis Progression.” Nature Communications 13(1): 5202. https://doi.org/10.1038/s41467-022-32788-x

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