Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling

References

[1] Ranger, Tom A., Andrea M. Y. Wong, Jill L. Cook, and Jamie E. Gaida. 2016. “Is There an Association Between Tendinopathy and Diabetes Mellitus? A Systematic Review With Meta-Analysis.” British Journal of Sports Medicine 50: 982-989. https://doi.org/10.1136/bjsports-2015-094735

[2] Afolabi, Babalola Ishamel, Bukunmi Michael Idowu, and Stephen Olaoluwa. 2021. “Achilles Tendon Degeneration on Ultrasound in Type 2 Diabetic Patients.” Journal of Ultrasonography 20e: 291-299. https://doi.org/10.15557/JoU.2020.0051

[3] Aydeniz, A., S. Gursoy, and E. Guney. 2008. “Which Musculoskeletal Complications Are Most Frequently Seen in Type 2 Diabetes Mellitus?” Journal of International Medical Research 36: 505-511. https://doi.org/10.1177/147323000803600315

[4] Spoendlin, Julia, Christian Meier, Susan S. Jick, and Christoph R. Meier. 2016. “Achilles or Biceps Tendon Rupture in Women and Men With Type 2 Diabetes: A Population-Based Case-Control Study.” Journal of Diabetes and Its Complications 30: 903-909. https://doi.org/10.1016/j.jdiacomp.2016.02.017

[5] Guney, A., F. Vatansever, I. Karaman, I. Kafadar, M. Oner, and C. Turk. 2015. “Biomechanical Properties of Achilles Tendon in Diabetic vs. Non-Diabetic Patients.” Experimental and Clinical Endocrinology & Diabetes 123: 428-432. https://doi.org/10.1055/s-0035-1549889

[6] Lu, Pan-Pan, Min-Hao Chen, Guang-Chun Dai, Ying-Juan Li, Liu Shi, and Yun-Feng Rui. 2020. “Understanding Cellular and Molecular Mechanisms of Pathogenesis of Diabetic Tendinopathy.” World Journal of Stem Cells 12: 1255-1275. https://doi.org/10.4252/wjsc.v12.i11.1255

[7] Alrouji, Mohamed, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Nada A. Ashour, Majid S. Jabir, Walaa A. Negm, and Gaber El-Saber Batiha. 2024. “Metformin Role in Parkinson's Disease: A Double-Sword Effect.” Molecular and Cellular Biochemistry 479: 975-991. https://doi.org/10.1007/s11010-023-04771-7

[8] Petrie, John R. 2024. “Metformin Beyond Type 2 Diabetes: Emerging and Potential New Indications.” Diabetes, Obesity and Metabolism 26(Suppl 3): 31-41. https://doi.org/10.1111/dom.15756

[9] Zhang, Jianying, Roshawn Brown, MaCalus V. Hogan, Kentaro Onishi, and James H.-C. Wang. 2023. “Metformin Improves Tendon Degeneration by Blocking Translocation of HMGB1 and Suppressing Tendon Inflammation and Senescence in Aging Mice.” Journal of Orthopaedic Research 41: 1162-1176. https://doi.org/10.1002/jor.25470

[10] Zhang, Jianying, Feng Li, Daibang Nie, Kentaro Onishi, MaCalus V. Hogan, and James H.-C. Wang. 2020. “Effect of Metformin on Development of Tendinopathy Due to Mechanical Overloading in an Animal Model.” Foot & Ankle International 41: 1455-1465. https://doi.org/10.1177/1071100720966318

[11] Chang, Renin, Ting-Yu Tu, Yao-Min Hung, Jing-Yang Huang, Mei-Chia Chou, and James Cheng-Chung Wei. 2022. “Metformin Use Is Associated With a Lower Risk of Rotator Cuff Disease in Patients With Type 2 Diabetes Mellitus.” Diabetes & Metabolism 48: 101368. https://doi.org/10.1016/j.diabet.2022.101368

[12] Tolcher, Anthony W., Wells A. Messersmith, Stanislaw M. Mikulski, Kyriakos P. Papadopoulos, Eunice L. Kwak, Darlene G. Gibbon, Amita Patnaik, et al. 2012. “Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors.” Journal of Clinical Oncology 30: 2348-2353. https://doi.org/10.1200/jco.2011.36.8282

[13] Coombes, Brooke K., Leanne Bisset, and Bill Vicenzino. 2010. “Efficacy and Safety of Corticosteroid Injections and Other Injections for Management of Tendinopathy: A Systematic Review of Randomised Controlled Trials.” The Lancet 376: 1751-1767. https://doi.org/10.1016/S0140-6736(10)61160-9

[14] Riley, Graham. 2008. “Tendinopathy-From Basic Science to Treatment.” Nature Clinical Practice Rheumatology 4: 82-89. https://doi.org/10.1038/ncprheum0700

[15] Gibbon, A., H. Hobbs, W. van der Merwe, S. M. Raleigh, J. Cook, C. J. Handley, M. Posthumus, M. Collins, and A. V. September. 2017. “The MMP3 Gene in Musculoskeletal Soft Tissue Injury Risk Profiling: A Study in Two Independent Sample Groups.” Journal of Sports Sciences 35: 655-662. https://doi.org/10.1080/02640414.2016.1183806

[16] Lin, Yu-Cheng, Ying-Juan Li, Yun-Feng Rui, Guang-Chun Dai, Liu Shi, Hong-Liang Xu, Ming Ni, and Song Zhao, Hui Chen. 2017. “The Effects of High Glucose on Tendon-Derived Stem Cells: Implications of the Pathogenesis of Diabetic Tendon Disorders.” Oncotarget 8: 17518-17528. https://doi.org/10.18632/oncotarget.15418

[17] Koch, Ute, Rajwinder Lehal, and Freddy Radtke. 2013. “Stem Cells Living With a Notch.” Development 140: 689-704. https://doi.org/10.1242/dev.080614

[18] Dong, Yufeng, Alana M. Jesse, Anat Kohn, Lea M. Gunnell, Tasuku Honjo, Michael J. Zuscik, Regis J. O'Keefe, and Matthew J. Hilton. 2010. “RBPjκ-Dependent Notch Signaling Regulates Mesenchymal Progenitor Cell Proliferation and Differentiation During Skeletal Development.” Development 137: 1461-1471. https://doi.org/10.1242/dev.042911

[19] Hilton, Matthew J., Xiaolin Tu, Ximei Wu, Shuting Bai, Haibo Zhao, Tatsuya Kobayashi, Henry M. Kronenberg, et al. 2008. “Notch Signaling Maintains Bone Marrow Mesenchymal Progenitors by Suppressing Osteoblast Differentiation.” Nature Medicine 14: 306-314. https://doi.org/10.1038/nm1716

[20] Matsushita, Yuki, Hiroaki Manabe, Takahiro Ohyama, Shogo Nakamura, Mizuki Nagata, Wanida Ono, and Noriaki Ono. 2023. “Hes1 Marks Peri-Condensation Mesenchymal Cells That Generate Both Chondrocytes and Perichondrial Cells in Early Bone Development.” Journal of Biological Chemistry 299: 104805. https://doi.org/10.1016/j.jbc.2023.104805

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