METTL5-mediated 18S rRNA m⁶A modification enhances ribosome assembly and ABA response in Arabidopsis

References

[1] Shen, Lisha. 2024. “Epitranscriptomic Regulation Through Phase Separation in Plants.” Trends in Plant Science in press. https://doi.org/10.1016/j.tplants.2024.11.012

[2] Shen, Lisha, Jinqi Ma, Ping Li, Yujin Wu, and Hao Yu. 2023. “Recent Advances in the Plant Epitranscriptome.” Genome Biology 24(1): 43. https://doi.org/10.1186/s13059-023-02872-6

[3] Shao, Yanlin, Chui Eng Wong, Lisha Shen, and Hao Yu. 2021. “N⁶-Methyladenosine Modification Underlies Messenger RNA Metabolism and Plant Development.” Current Opinion in Plant Biology 63: 102047. https://doi.org/10.1016/j.pbi.2021.102047

[4] Noller, Harry F. 1991. “Ribosomal RNA and Translation.” Annual Review of Biochemistry 60: 191-227. https://doi.org/10.1146/annurev.bi.60.070191.001203

[5] Ramakrishnan, V. 2002. “Ribosome Structure and the Mechanism of Translation.” Cell 108: 557-572. https://doi.org/10.1016/s0092-8674(02)00619-0

[6] Smirnova, Julia, Justus Loerke, Gunnar Kleinau, Andrea Schmidt, Jörg Bürger, Etienne H. Meyer, Thorsten Mielke, et al. 2023. “Structure of the Actively Translating Plant 80S Ribosome at 2.2 Å Resolution.” Nature Plants 9: 987-1000. https://doi.org/10.1038/s41477-023-01407-y

[7] Xu, Tao, Xiaowei Wu, Chui Eng Wong, Sheng Fan, Yu Zhang, Songyao Zhang, Zhe Liang, et al. 2022. “FIONA1-Mediated m⁶A Modification Regulates the Floral Transition in Arabidopsis.” Advanced Science 9: e2103628. https://doi.org/10.1002/advs.202103628

[8] Wang, Ping, Katelyn A. Doxtader, and Yunsun Nam. 2016. “Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.” Molecular Cell 63: 306-317. https://doi.org/10.1016/j.molcel.2016.05.041

[9] Linder, Bastian, Anya V. Grozhik, Anthony O. Olarerin-George, Cem Meydan, Christopher E. Mason, and Samie R. Jaffrey. 2015. “Single-Nucleotide-Resolution Mapping of m⁶A and m⁶Am Throughout the Transcriptome.” Nature Methods 12: 767-772. https://doi.org/10.1038/nmeth.3453

[10] Chen, Binbin, Ying Huang, Shuiqing He, Peng Yu, Lirong Wu, and Hao Peng. 2023. “N⁶-Methyladenosine Modification in 18S rRNA Promotes Tumorigenesis and Chemoresistance via HSF4b/HSP90B1/Mutant p53 Axis.” Cell Chemical Biology 30: 144-158.e10. https://doi.org/10.1016/j.chembiol.2023.01.006

[11] Peng, Hao, Binbin Chen, Wei Wei, Siyao Guo, Hui Han, Chunlong Yang, Jieyi Ma, et al. 2022. “N⁶-Methyladenosine (m⁶A) in 18S rRNA Promotes Fatty Acid Metabolism and Oncogenic Transformation.” Nature Metabolism 4: 1041-1054. https://doi.org/10.1038/s42255-022-00622-9

[12] Sepich-Poore, Caraline, Zhong Zheng, Emily Schmitt, Kailong Wen, Zijie Scott Zhang, Xiao-Long Cui, Qing Dai, et al. 2022. “The METTL5-TRMT112 N⁶-Methyladenosine Methyltransferase Complex Regulates mRNA Translation via 18S rRNA Methylation.” Journal of Biological Chemistry 298(3), 101590. https://doi.org/10.1016/j.jbc.2022.101590

[13] Song, Peizhe, Enlin Tian, Zhihe Cai, Xu Chen, Shuyan Chen, Kemiao Yu, Hanxiao Bian, Kai He, and Guifang Jia. 2024. “Methyltransferase ATMETTL5 Writes m⁶A on 18S Ribosomal RNA to Regulate Translation in Arabidopsis.” New Phytologist 244: 571-587. https://doi.org/10.1111/nph.20034

[14] Sappl, Pia G., Adam J. Carroll, Rachael Clifton, Ryan Lister, James Whelan, A. Harvey Millar, and Karam B. Singh. 2009. “The Arabidopsis Glutathione Transferase Gene Family Displays Complex Stress Regulation and Co-Silencing Multiple Genes Results in Altered Metabolic Sensitivity to Oxidative Stress.” The Plant Journal 58: 53-68. https://doi.org/10.1111/j.1365-313X.2008.03761.x

[15] Khatter, Heena, Alexander G. Myasnikov, S. Kundhavai Natchiar, and Bruno P. Klaholz. 2015. “Structure of the Human 80S Ribosome.” Nature 520: 640-645. https://doi.org/10.1038/nature14427

[16] Kisly, Ivan, Jaanus Remme, and Tiina Tamm. 2019. “Ribosomal Protein eL24, Involved in Two Intersubunit Bridges, Stimulates Translation Initiation and Elongation.” Nucleic Acids Research 47: 406-420. https://doi.org/10.1093/nar/gky1083

[17] Rong, Bowen, Qian Zhang, Jinkai Wan, Shenghui Xing, Ruofei Dai, Yuan Li, Jiabin Cai, et al. 2020. “Ribosome 18S m⁶A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.” Cell Reports 33(12), 108544. https://doi.org/10.1016/j.celrep.2020.108544

[18] van Tran, Nhan, Felix G. M. Ernst, Ben R. Hawley, Christiane Zorbas, Nathalie Ulryck, Philipp Hackert, Katherine E. Bohnsack, et al. 2019. “The Human 18S rRNA m⁶A Methyltransferase METTL5 Is Stabilized by TRMT112.” Nucleic Acids Research 47: 7719-7733. https://doi.org/10.1093/nar/gkz619

[19] Guo, Zhengfei, Xiaoyu Wang, Yan Li, Aiming Xing, Chengyun Wu, Daojun Li, Chunfei Wang, et al. 2023. “Arabidopsis SMO2 Modulates Ribosome Biogenesis by Maintaining the RID2 Abundance During Organ Growth.” The Plant Journal 114: 96-109. https://doi.org/10.1111/tpj.16121

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