Enhancing human gut health: Global innovations in dysbiosis management

Reda El Boukhari; Maima Matin; Latifa Bouissane; Michał Ławiński; Oleh Lushchak; Rajeev K. Singla; Michel-Edwar Mickael; Jordi Mayneris-Perxachs; Maria Eleni Grafakou; Shuhua Xu; Bowen Liu; Jiayi Guan; Andrzej Półtorak; Arkadiusz Szpicer; Agnieszka Wierzbicka; Nikolay T. Tzvetkov; Maciej Banach; Jarosław Olav Horbańczuk; Artur Jóźwik; Marco Cascella; Bairong Shen; Vasil Radoslavov Pirgozliev; Dongdong Wang; Olena Litvinova; Olga Adamska; Agnieszka Kamińska; Marcin Łapiński; Artur Stolarczyk; Ioana Berindan-Neagoe; Luigi Milella; Andy Wai Kan Yeung; Prashanth Suravajhala; Anupam Bishayee; Ronan Lordan; Laszlo Barna Iantovics; Ricardo Lagoa; Monika Michalczuk; Jivko Stoyanov; A. Douglas Kinghorn; Banaz Jalil; Wolfram Weckwerth; Bey Hing Goh; Meng-Yao Li; Gyaneshwer Chaubey; Gian Luigi Russo; Sara Frazzini; Luciana Rossi; Maurizio Battino; Wei Jia; Qi Su; Xiaoqiang Ma; Judith M. Rollinger; Simon K.-M. R. Rittmann; Helen Sheridan; John J. Walsh; Gérard Lizard; Tomasz M. Karpiński; Ana Sanches Silva; Jakub Piwowarski; Liwei Xie; Tai-Ping Fan; Francesca Giampieri; Adil El Midaoui; Ka-Hing Wong; Ren-You Gan; Ahmed Fatimi; Atanas G. Atanasov

doi:10.1002/imt2.70028

iMeta ›› 2025, Vol. 4 ›› Issue (3) :e70028 DOI: 10.1002/imt2.70028

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Enhancing human gut health: Global innovations in dysbiosis management

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¹. Chemical Science and Engineering Research Team (ERSIC), Department of Chemistry, Polydisciplinary Faculty of Beni Mellal (FPBM), Sultan Moulay Slimane University (USMS), Beni Mellal, Morocco

². Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzębiec, Poland

³. Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, Beni Mellal, Morocco

⁴. Department of General, Gastroenterologic and Oncologic Surgery, Medical University of Warsaw, Warsaw, Poland

⁵. Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine

⁶. Research and Development University, Ivano-Frankivsk, Ukraine

⁷. Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China

⁸. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

⁹. Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain

¹⁰. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

¹¹. Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Parc Hospitalari Martí i Julià, Salt, Spain

¹². Chair of Pharmaceutical Biology, Faculty of Pharmacy and Chemistry, University of Regensburg, Germany

¹³. Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China

¹⁴. Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China

¹⁵. School of Agriculture, Yunnan University, Kunming, China

¹⁶. Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China

¹⁷. Department of Technique and Food Development, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences, Warsaw, Poland

¹⁸. Department of Biochemical Pharmacology and Drug Design, Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, Sofia, Bulgaria

¹⁹. Faculty of Medicine, The John Paul II Catholic University of Lublin (KUL), Lublin, Poland

²⁰. Department of Cardiology and Adult Congenital Heart Diseases, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

²¹. Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland

²². Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

²³. Anesthesia and Pain Medicine, Department of Medicine, Surgery and Dentistry “Scuola MedicaSalernitana”, University of Salerno, Baronissi, Italy

²⁴. Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital,Sichuan University, Chengdu, Sichuan, China

²⁵. Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China

²⁶. National Institute of Poultry Husbandry, Harper Adams University, Newport, UK

²⁷. Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

²⁸. Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

²⁹. National University of Pharmacy of the Ministry of Health of Ukraine, Kharkiv, Ukraine

³⁰. Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria

³¹. Faculty of Medicine, Collegium Medicum Cardinal Stefan Wyszyński University in Warsaw, Warsaw, Poland

³². Orthopaedic and Rehabilitation Department, Medical University of Warsaw, Warsaw, Poland

³³. Department of Genomics, MEDFUTURE - Institute for Biomedical Research“Iuliu Hațieganu” University of Medicine and Pharmacy No. 23, Cluj-Napoca, Romania

³⁴. Department of Health Sciences, University of Basilicata, Potenza, Italy

³⁵. Oral and Maxillofacial Radiology, Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong SAR

³⁶. Amrita School of Biotechnology, Amrita Viswa Vidyapeetham, Clappana, Kerala, India

³⁷. Department of Biosciences, Manipal University Jaipur, Dehmi Kala, Jaipur, Rajasthan, India

³⁸. Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, Florida, USA

³⁹. The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

⁴⁰. Department of Electrical Engineering and Information Technology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu, Mures, Romania

⁴¹. ESTG-Polytechnic Institute of Leiria, Morro do Lena-Alto do Vieiro, Leiria, Portugal

⁴². LSRE-LCM-Associate Laboratory in Chemical Engineering, University of Porto, Porto, Portugal

⁴³. Department of Animal Breeding, Institute of Animal Sciences, Warsaw University of Life Sciences - SGGW, Warsaw, Poland

⁴⁴. Swiss Paraplegic Research, Nottwil, Switzerland

⁴⁵. Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland

⁴⁶. College of Pharmacy, Ohio State University, Columbus, Ohio, USA

⁴⁷. Pharmacognosy and Phytotherapy, UCL School of Pharmacy, London, UK

⁴⁸. Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria

⁴⁹. Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria

⁵⁰. Sunway Biofunctional Molecules Discovery Centre (SBMDC), School of Medical and Life Sciences, Subang Jaya, Malaysia

⁵¹. Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia

⁵². Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, New South Wales, Australia

⁵³. State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

⁵⁴. Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

⁵⁵. Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

⁵⁶. National Research Council, Institute of Food Sciences, Avellino, Italy

⁵⁷. Department of Veterinary Medicine and Animal Science (DIVAS), University of Milan, Lodi, Italy

⁵⁸. Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy

⁵⁹. Joint Laboratory on Food Science, Nutrition, and Intelligent Processing of Foods, Polytechnic University of Marche (Italy), Universidad Europea del Atlántico (Spain), and Jiangsu University (China), Ancona, Italy

⁶⁰. International Joint Research, Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang, China

⁶¹. Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong SAR

⁶². Microbiota I-Center, Shatin, Hong Kong SAR

⁶³. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR

⁶⁴. Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China

⁶⁵. Division of Pharmacognosy, Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria

⁶⁶. Archaea Physiology & Biotechnology Group, Department of Functional and Evolutionary Ecology, University of Vienna, Vienna, Austria

⁶⁷. The NatPro Centre & School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland

⁶⁸. Université Bourgogne Europe/INSERM, 21000 Dijon and PHYNOHA Consulting, Fontaine-lès-Dijon, France

⁶⁹. Department of Medical Microbiology, Poznań University of Medical Sciences, Poznań, Poland

⁷⁰. University of Coimbra, Faculty of Pharmacy, Polo III, Azinhaga de Santa Comba, Coimbra, Portugal

⁷¹. Centre for Animal Science Studies (CECA), ICETA, University of Porto, Porto, Portugal

⁷². Microbiota Lab, Department of Pharmaceutical Microbiology and Bioanalysis, Medical University of Warsaw, Warsaw, Poland

⁷³. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China

⁷⁴. School of Life & Health Sciences, Fuyao University of Science & Technology, Fuzhou, Fujian, China

⁷⁵. Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain

⁷⁶. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China

⁷⁷. Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes, Morocco

⁷⁸. Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada

⁷⁹. Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR

⁸⁰. Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR

⁸¹. Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, India

renyou.gan@polyu.edu.hk

a.fatimi@usms.ma

atanas.atanasov@lbg.ac.at

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Reda El Boukhari, Maima Matin, Latifa Bouissane, Michał Ławiński, Oleh Lushchak, Rajeev K. Singla, Michel-Edwar Mickael, Jordi Mayneris-Perxachs, Maria Eleni Grafakou, Shuhua Xu, Bowen Liu, Jiayi Guan, Andrzej Półtorak, Arkadiusz Szpicer, Agnieszka Wierzbicka, Nikolay T. Tzvetkov, Maciej Banach, Jarosław Olav Horbańczuk, Artur Jóźwik, Marco Cascella, Bairong Shen, Vasil Radoslavov Pirgozliev, Dongdong Wang, Olena Litvinova, Olga Adamska, Agnieszka Kamińska, Marcin Łapiński, Artur Stolarczyk, Ioana Berindan-Neagoe, Luigi Milella, Andy Wai Kan Yeung, Prashanth Suravajhala, Anupam Bishayee, Ronan Lordan, Laszlo Barna Iantovics, Ricardo Lagoa, Monika Michalczuk, Jivko Stoyanov, A. Douglas Kinghorn, Banaz Jalil, Wolfram Weckwerth, Bey Hing Goh, Meng-Yao Li, Gyaneshwer Chaubey, Gian Luigi Russo, Sara Frazzini, Luciana Rossi, Maurizio Battino, Wei Jia, Qi Su, Xiaoqiang Ma, Judith M. Rollinger, Simon K.-M. R. Rittmann, Helen Sheridan, John J. Walsh, Gérard Lizard, Tomasz M. Karpiński, Ana Sanches Silva, Jakub Piwowarski, Liwei Xie, Tai-Ping Fan, Francesca Giampieri, Adil El Midaoui, Ka-Hing Wong, Ren-You Gan, Ahmed Fatimi, Atanas G. Atanasov. Enhancing human gut health: Global innovations in dysbiosis management. iMeta, 2025, 4(3): e70028 DOI:10.1002/imt2.70028

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