Spaceflight redefines ageing-associated microbiota

Yuan Sun , Sai Liu , Long Chen , Zheng Zhou , Mengyu Ma , Jinran Li , Yi Lu , Yiting Shi , Tingting Yao , Ruizhi Feng , Qiulun Lu , Fatimah Qassadi , Philip M. Williams , Tanya M. Monaghan , Guangji Wang , Zheying Zhu , Xinuo Li

iMeta ›› 2025, Vol. 4 ›› Issue (3) : e70023

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iMeta ›› 2025, Vol. 4 ›› Issue (3) :e70023 DOI: 10.1002/imt2.70023
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Spaceflight redefines ageing-associated microbiota
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Yuan Sun, Sai Liu, Long Chen, Zheng Zhou, Mengyu Ma, Jinran Li, Yi Lu, Yiting Shi, Tingting Yao, Ruizhi Feng, Qiulun Lu, Fatimah Qassadi, Philip M. Williams, Tanya M. Monaghan, Guangji Wang, Zheying Zhu, Xinuo Li. Spaceflight redefines ageing-associated microbiota. iMeta, 2025, 4(3): e70023 DOI:10.1002/imt2.70023

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References

[1]

Auñón-Chancellor, Serena M., James M. Pattarini, Stephan Moll, and Ashot Sargsyan. 2020. “Venous Thrombosis During Spaceflight.” New England Journal of Medicine 382: 89-90. https://doi.org/10.1056/NEJMc1905875

[2]

Vico, Laurence, and Alan Hargens. 2018. “Skeletal Changes During and After Spaceflight.” Nature Reviews Rheumatology 14: 229-245. https://doi.org/10.1038/nrrheum.2018.37

[3]

Tierney, Braden T., JangKeun Kim, Eliah G. Overbey, Krista A. Ryon, Jonathan Foox, Maria A. Sierra, Chandrima Bhattacharya, Namita Damle, Deena Najjar, and Jiwoon Park. 2024. “Longitudinal Multi-Omics Analysis of Host Microbiome Architecture and Immune Responses During Short-Term Spaceflight.” Nature Microbiology 9: 1661-1675. https://doi.org/10.1038/s41564-024-01635-8

[4]

da Silveira, Willian A., Hossein Fazelinia, Sara Brin Rosenthal, Evagelia C. Laiakis, Man S. Kim, Cem Meydan, Yared Kidane, et al. 2020. “Comprehensive Multi-Omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.” Cell 183: 1185-1201.e20. https://doi.org/10.1016/j.cell.2020.11.002

[5]

Kim, JangKeun, Braden T. Tierney, Eliah G. Overbey, Ezequiel Dantas, Matias Fuentealba, Jiwoon Park, S Anand Narayanan, Fei Wu, Deena Najjar, and Christopher R. Chin. 2024. “Single-Cell Multi-Ome and Immune Profiles of the Inspiration4 Crew Reveal Conserved, Cell-Type, and Sex-Specific Responses to Spaceflight.” Nature Communications 15: 4954. https://doi.org/10.1038/s41467-024-49211-2

[6]

Shandilya, Shruti, Sandeep Kumar, Niraj Kumar Jha, Kavindra Kumar Kesari, and Janne Ruokolainen. 2022. “Interplay of Gut Microbiota and Oxidative Stress: Perspective on Neurodegeneration and Neuroprotection.” Journal of Advanced Research 38: 223-244. https://doi.org/10.1016/j.jare.2021.09.005

[7]

Ghosh, Tarini Shankar, Fergus Shanahan, and Paul W. O'Toole. 2022. “The Gut Microbiome as a Modulator of Healthy Ageing.” Nature Reviews Gastroenterology & Hepatology 19: 565-584. https://doi.org/10.1038/s41575-022-00605-x

[8]

Garcia-Medina, Sebastian J., Karolina Sienkiewicz, S. Anand Narayanan, Eliah G. Overbey, Kirill Grigorev, Krista A. Ryon, Marissa Burke, Jacqueline Proszynski, Braden Tierney, and Caleb M. Schmidt. 2024. “Genome and Clonal Hematopoiesis Stability Contrasts With Immune, cfDNA, Mitochondrial, and Telomere Length Changes During Short Duration Spaceflight.” Precision Clinical Medicine 7: pbae007. https://doi.org/10.1093/pcmedi/pbae007

[9]

Tierney, Braden T., JangKeun Kim, Eliah G. Overbey, Krista A. Ryon, Jonathan Foox, Maria A. Sierra, Chandrima Bhattacharya, et al. 2024. “Longitudinal Multi-Omics Analysis of Host Microbiome Architecture and Immune Responses During Short-Term Spaceflight.” Nature Microbiology 9: 1661-1675. https://doi.org/10.1038/s41564-024-01635-8

[10]

Liu, Xiaomin, Xin Tong, Jie Zhu, Liu Tian, Zhuye Jie, Yuanqiang Zou, Xiaoqian Lin, Hewei Liang, Wenxi Li, and Yanmei Ju. 2021. “Metagenome-Genome-Wide Association Studies Reveal Human Genetic Impact on the Oral Microbiome.” Cell Discovery 7: 117. https://doi.org/10.1038/s41421-021-00356-0

[11]

van der Velde, K Joeri, Floris Imhann, Bart Charbon, Chao Pang, David van Enckevort, Mariska Slofstra, Ruggero Barbieri, Rudi Alberts, Dennis Hendriksen, and Fleur Kelpin. 2019. “MOLGENIS Research: Advanced Bioinformatics Data Software for Non-Bioinformaticians.” Bioinformatics 35: 1076-1078. https://doi.org/10.1093/bioinformatics/bty742

[12]

Zeng, Shi-Yu, Yi-Fu Liu, Jiang-Hua Liu, Zhao-Lin Zeng, Hui Xie, and Jiang-Hua Liu. 2023. “Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives.” Aging and Disease 14: 2015. https://doi.org/10.14336/AD.2023.0325

[13]

Zhang, Qiang, Rong Zou, Min Guo, Mengmeng Duan, Quan Li, and Huajun Zheng. 2021. “Comparison of Gut Microbiota Between Adults With Autism Spectrum Disorder and Obese Adults.” PeerJ 9: e10946. https://doi.org/10.7717/peerj.10946

[14]

Richarte, Vanesa, Cristina Sánchez-Mora, Montserrat Corrales, Christian Fadeuilhe, Laura Vilar-Ribó, Lorena Arribas, Estela Garcia, Silvia Karina Rosales-Ortiz, Alejandro Arias-Vasquez, and María Soler-Artigas. 2021. “Gut Microbiota Signature in Treatment-Naïve Attention-Deficit/Hyperactivity Disorder.” Translational Psychiatry 11: 382. https://doi.org/10.1038/s41398-021-01504-6

[15]

Kwon, Gayeung, Jiyun Lee, and Young-Hee Lim. 2016. “Dairy Propionibacterium Extends the Mean Lifespan of Caenorhabditis Elegans via Activation of the Innate Immune System.” Scientific Reports 6: 31713. https://doi.org/10.1038/srep31713

[16]

Langfelder, Peter, and Steve Horvath. 2008. “WGCNA: An R Package for Weighted Correlation Network Analysis.” BMC Bioinformatics 9: 559. https://doi.org/10.1186/1471-2105-9-559

[17]

Grigorev, Kirill, Theodore M. Nelson, Eliah G. Overbey, Nadia Houerbi, JangKeun Kim, Deena Najjar, Namita Damle, Evan E. Afshin, Krista A. Ryon, and Jean Thierry-Mieg. 2024. “Direct RNA Sequencing of Astronaut Blood Reveals Spaceflight-Associated m6A Increases and Hematopoietic Transcriptional Responses.” Nature Communications 15: 4950. https://doi.org/10.1038/s41467-024-48929-3

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