Gut microbiota in cancer: From molecular mechanisms to precision medicine applications

References

[1] Alipour, Majid. 2021. “Molecular Mechanism of Helicobacter Pylori-Induced Gastric Cancer.” Journal of Gastrointestinal Cancer 52: 23-30. https://doi.org/10.1007/s12029-020-00518-5

[2] Rubinstein, Mara Roxana, Xiaowei Wang, Wendy Liu, Yujun Hao, Guifang Cai, and Yiping W. Han. 2013. “Fusobacterium Nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via Its FadA Adhesin.” Cell Host & Microbe 14: 195-206. https://doi.org/10.1016/j.chom.2013.07.012

[3] Zhao, Huakan, Lei Wu, Guifang Yan, Yu Chen, Mingyue Zhou, Yongzhong Wu, and Yongsheng Li. 2021. “Inflammation and Tumor Progression: Signaling Pathways and Targeted Intervention.” Signal Transduction and Targeted Therapy 6: 263. https://doi.org/10.1038/s41392-021-00658-5.

[4] Li, Yupeng, and Stephen S. Hecht. 2022. “Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed.” International Journal of Molecular Sciences 23: 4559. https://doi.org/10.3390/ijms23094559

[5] Wolf, Andrea J., and David M. Underhill. 2018. “Peptidoglycan Recognition by the Innate Immune System.” Nature Reviews. Immunology 18: 243-254. https://doi.org/10.1038/nri.2017.136

[6] Yang, Yongzhi, Wenhao Weng, Junjie Peng, Leiming Hong, Lei Yang, Yuji Toiyama, Renyuan Gao, et al. 2017. “Fusobacterium Nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-Regulating Expression of MicroRNA-21.” Gastroenterology 152: 851-866.e24. https://doi.org/10.1053/j.gastro.2016.11.018

[7] Hu, Jianping, Chaokui Wang, Xinyue Huang, Shenglan Yi, Su Pan, Yiting Zhang, Gangxiang Yuan, et al. 2021. “Gut Microbiota-Mediated Secondary Bile Acids Regulate Dendritic Cells to Attenuate Autoimmune Uveitis through TGR5 Signaling.” Cell Reports 36: 109726. https://doi.org/10.1016/j.celrep.2021.109726

[8] Davie, James R. 2003. “Inhibition of Histone Deacetylase Activity by Butyrate.” The Journal of Nutrition 133(7 Suppl): 2485S-2493S. https://doi.org/10.1093/jn/133.7.2485S

[9] Gao, Xueliang, Gustavo W. Leone, and Haizhen Wang. 2020. “Cyclin D-CDK4/6 Functions in Cancer.” Advances in Cancer Research 148: 147-169. https://doi.org/10.1016/bs.acr.2020.02.002

[10] Seo, Su-Kil, and Byungsuk Kwon. 2023. “Immune Regulation Through Tryptophan Metabolism.” Experimental & Molecular Medicine 55: 1371-1379. https://doi.org/10.1038/s12276-023-01028-7

[11] Liu, Wei-Qing, Wan-Rong Lin, Li Yan, Wen-Hao Xu, and Jun Yang. 2024. “Copper Homeostasis and Cuproptosis in Cancer Immunity and Therapy.” Immunological Reviews 321: 211-227. https://doi.org/10.1111/imr.13276

[12] Miggelbrink, Alexandra M., Joshua D. Jackson, Selena J. Lorrey, Ethan S. Srinivasan, Jessica Waibl-Polania, Daniel S. Wilkinson, and Peter E. Fecci. 2021. “CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 27: 5742-5752. https://doi.org/10.1158/1078-0432.CCR-21-0206

[13] Zińczuk, Justyna, Konrad Zaręba, Joanna Kamińska, Olga Martyna Koper-Lenkiewicz, Violetta Dymicka-Piekarska, Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz, et al. 2021. “Association of Tumour Microenvironment With Protein Glycooxidation, DNA Damage, and Nitrosative Stress in Colorectal Cancer.” Cancer Management and Research 13: 6329-6348. https://doi.org/10.2147/CMAR.S314940

[14] Wu, Liwei, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, and Chuanyong Guo. 2021. “The Gut Microbiome-Bile Acid Axis in Hepatocarcinogenesis.” Biomedicine & Pharmacotherapy 133: 111036. https://doi.org/10.1016/j.biopha.2020.111036

[15] Yang, Qiqing, Bin Wang, Qinghui Zheng, Heyu Li, Xuli Meng, Fangfang Zhou, and Long Zhang. 2023. “A Review of Gut Microbiota-Derived Metabolites in Tumor Progression and Cancer Therapy.” Advanced Science 10: e2207366. https://doi.org/10.1002/advs.202207366

[16] Jaye, Kayla, Chun Guang Li, Dennis Chang, and Deep Jyoti Bhuyan. 2022. “The Role of Key Gut Microbial Metabolites in the Development and Treatment of Cancer.” Gut Microbes 14: 2038865. https://doi.org/10.1080/19490976.2022.2038865

[17] Kuo, Wei-Ting, Li Zuo, Matthew A. Odenwald, Shariq Madha, Gurminder Singh, Christine B. Gurniak, Clara Abraham, and Jerrold R. Turner. 2021. “The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.” Gastroenterology 161: 1924-1939. https://doi.org/10.1053/j.gastro.2021.08.047

[18] Liu, Runping, Xiaojiaoyang Li, Phillip B. Hylemon, and Huiping Zhou. 2018. “Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2-Mediated Yes-Associated Protein Activation.” The American Journal of Pathology 188: 2042-2058. https://doi.org/10.1016/j.ajpath.2018.05.015

[19] Kaźmierczak-Siedlecka, Karolina, Agnieszka Daca, Mateusz Fic, Thierry van de Wetering, Marcin Folwarski, and Wojciech Makarewicz. 2020. “Therapeutic Methods of Gut Microbiota Modification in Colorectal Cancer Management - Fecal Microbiota Transplantation, Prebiotics, Probiotics, and Synbiotics.” Gut Microbes 11: 1518-1530. https://doi.org/10.1080/19490976.2020.1764309

[20] Danne, Camille, Nathalie Rolhion, and Harry Sokol. 2021. “Recipient Factors in Faecal Microbiota Transplantation: One Stool Does Not Fit All.” Nature Reviews. Gastroenterology & Hepatology 18: 503-513. https://doi.org/10.1038/s41575-021-00441-5

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