Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations

References

[1] Bray, Freddie, Mathieu Laversanne, Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, Isabelle Soerjomataram, and Ahmedin Jemal. 2024. “Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.” CA: A Cancer Journal for Clinicians 74: 229-263. https://doi.org/10.3322/caac.21834

[2] Zhu, Yao, Miao Mo, Yu Wei, Junlong Wu, Jian Pan, Stephen J. Freedland, Ying Zheng, and Dingwei Ye. 2021. “Epidemiology and Genomics of Prostate Cancer in Asian Men.” Nature Reviews Urology 18: 282-301. https://doi.org/10.1038/s41585-021-00442-8

[3] Mukherjee, Sumit, Sunanda Biswas Mukherjee, and Milana Frenkel-Morgenstern. 2023. “Functional and Regulatory Impact of Chimeric RNAs in Human Normal and Cancer Cells.” Wiley Interdisciplinary Reviews: RNA 14: e1777. https://doi.org/10.1002/wrna.1777

[4] Wang, Qiong, Bisheng Cheng, Sandeep Singh, Yiran Tao, Zhongqiu Xie, Fujun Qin, Xinrui Shi, et al. 2024. “A Protein-Encoding CCDC7 Circular RNA Inhibits the Progression of Prostate Cancer by Up-Regulating FLRT3.” NPJ Precision Oncology 8: 11. https://doi.org/10.1038/s41698-024-00503-2

[5] Li, Hui, and Qiong Wang. 2023. “Chimeric RNAs and Their Implication in Prostate Cancer.” Cancer Pathogenesis and Therapy 1: 216-219. https://doi.org/10.1016/j.cpt.2023.04.003

[6] Hu, Chenxi, Zaosong Zheng, Shiyu Pang, Yuanchao Zhu, Jirong Jie, Zhuocheng Lai, Xiangbo Zeng, et al. 2024. “Chimeric SFT2D2-TBX19 Promotes Prostate Cancer Progression by Encoding TBX19-202 Protein and Stabilizing Mitochondrial ATP Synthase Through ATP5F1A Phosphorylation.” Advanced Science 11: e2408426. https://doi.org/10.1002/advs.202408426

[7] Kumar, Shailesh, Angie Duy Vo, Fujun Qin, and Hui Li. 2016. “Comparative Assessment of Methods for the Fusion Transcripts Detection From RNA-Seq Data.” Scientific Reports 6: 21597. https://doi.org/10.1038/srep21597

[8] Singh, Sandeep, and Hui Li. 2021. “Comparative Study of Bioinformatic Tools for the Identification of Chimeric RNAs From RNA Sequencing.” RNA Biology 18: 254-267. https://doi.org/10.1080/15476286.2021.1940047

[9] Wang, Qiong, Junxiu Chen, Sandeep Singh, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Hui Li, and Hai Huang. 2022. “Profile of Chimeric RNAs and TMPRSS2-ERG e2e4 Isoform in Neuroendocrine Prostate Cancer.” Cell and Bioscience 12: 153. https://doi.org/10.1186/s13578-022-00893-5

[10] Qin, Fujun, Zhenguo Song, Mihaela Babiceanu, Yansu Song, Loryn Facemire, Ritambhara Singh, Mazhar Adli, and Hui Li. 2015. “Discovery of CTCF-Sensitive Cis-Spliced Fusion RNAs between Adjacent Genes in Human Prostate Cells.” PLoS Genetics 11: e1005001. https://doi.org/10.1371/journal.pgen.1005001

[11] Elfman, Justin, Lynette Goins, Tessa Heller, Sandeep Singh, Yuh-Hwa Wang, and Hui Li. 2024. “Discovery of a Polymorphic Gene Fusion via Bottom-Up Chimeric RNA Prediction.” Nucleic Acids Research 52: 4409-4421. https://doi.org/10.1093/nar/gkae258

[12] Kumari, Sangeeta, Vikas Sharma, Rahul Tiwari, Jay Prakash Maurya, Bharat Bhusan Subudhi, and Dhirodatta Senapati. 2022. “Therapeutic Potential of p53 Reactivation in Prostate Cancer: Strategies and Opportunities.” European Journal of Pharmacology 919: 174807. https://doi.org/10.1016/j.ejphar.2022.174807

[13] Wang, Qiong, Zean Li, Jin Yang, Shirong Peng, Qianghua Zhou, Kai Yao, Wenli Cai, et al. 2021. “Loss of NEIL3 Activates Radiotherapy Resistance in the Progression of Prostate Cancer.” Cancer Biology and Medicine 19: 1193-1210. https://doi.org/10.20892/j.issn.2095-3941.2020.0550

[14] Xiong, Zhi, Shun-Li Yu, Zhao-Xiang Xie, Rui-Lin Zhuang, Shi-Rong Peng, Qiong Wang, Ze Gao, et al. 2024. “Cancer-Associated Fibroblasts Promote Enzalutamide Resistance and PD-L1 Expression in Prostate Cancer Through CCL5-CCR5 Paracrine Axis.” iScience 27: 109674. https://doi.org/10.1016/j.isci.2024.109674

[15] Kristensen, Lasse S., Theresa Jakobsen, Henrik Hager, and Jørgen Kjems. 2022. “The Emerging Roles of circRNAs in Cancer and Oncology.” Nature Reviews Clinical Oncology 19: 188-206. https://doi.org/10.1038/s41571-021-00585-y

[16] Rickman, David S., Dorothee Pflueger, Benjamin Moss, Vanessa E. VanDoren, Chen X. Chen, Alexandre de la Taille, Rainer Kuefer, et al. 2009. “SLC45A3-ELK4 Is a Novel and Frequent Erythroblast Transformation-Specific Fusion Transcript in Prostate Cancer.” Cancer Research 69: 2734-2738. https://doi.org/10.1158/0008-5472.can-08-4926

[17] Pelon, Floriane, Brigitte Bourachot, Yann Kieffer, Ilaria Magagna, Fanny Mermet-Meillon, Isabelle Bonnet, Ana Costa, et al. 2020. “Cancer-Associated Fibroblast Heterogeneity in Axillary Lymph Nodes Drives Metastases in Breast Cancer Through Complementary Mechanisms.” Nature Communications 11: 404. https://doi.org/10.1038/s41467-019-14134-w

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