Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities

Yongpeng Shi; Zeran Chen; Tingyu Fang; Xingyao Chen; Youpeng Deng; Hao Qin; Min Lian; Juntao Shen; Yuru Zong; Huikuan Chu; Constanze Hoebinger; Hao Guo; Zhongshang Yuan; Jie Zheng; Yongjian Zhou; Yue Pan; Beatriz G. Mendes; Sonja Lang; Tim Hendrikx; Suling Zeng; Hailong Cao; Ling Yang; Lianmin Chen; Peng Chen; Lei Dai; Hua Wang; Shi Yin; Shu Zhu; Xiong Ma; Bernd Schnabl; Hanqing Chen; Yi Duan

doi:10.1002/imt2.265

iMeta ›› 2025, Vol. 4 ›› Issue (1) :e265 DOI: 10.1002/imt2.265

CORRESPONDENCE

Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities

Yongpeng Shi ¹^,²^,³
, Zeran Chen ⁴
, Tingyu Fang ²^,³
, Xingyao Chen ²^,³
, Youpeng Deng ²^,³
, Hao Qin ⁵
, Min Lian ⁶
, Juntao Shen ⁷
, Yuru Zong ⁴
, Huikuan Chu ⁸
, Constanze Hoebinger ⁹
, Hao Guo ¹⁰
, Zhongshang Yuan ¹¹
, Jie Zheng ¹²^,¹³^,¹⁴
, Yongjian Zhou ¹⁵
, Yue Pan ¹⁶^,¹⁷
, Beatriz G. Mendes ¹⁸
, Sonja Lang ¹⁹
, Tim Hendrikx ⁹
, Suling Zeng ²⁰
, Hailong Cao ²¹
, Ling Yang ⁸
, Lianmin Chen ²²
, Peng Chen ²³^,²⁴
, Lei Dai ⁷
, Hua Wang ²⁵^,²⁶
, Shi Yin ²⁷^,²⁸
, Shu Zhu ²^,³
, Xiong Ma ⁶
, Bernd Schnabl ²⁹
, Hanqing Chen ⁴
, Yi Duan ¹^,²^,³

Author information +

¹. Department of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

². Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

³. Key Laboratory of Immune Response and Immunotherapy, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

⁴. Department of Nutrition and Food Hygiene, School of Public Health, Capital Medical University, Beijing, China

⁵. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China

⁶. Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China

⁷. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

⁸. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

⁹. Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria

¹⁰. State Key Laboratory of Cellular Stress Biology, Xiang'an Hospital, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China

¹¹. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Institute for Medical Dataology, Shandong University, Jinan, China

¹². Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

¹³. Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the Peoples R China, Shanghai Key Laboratory for Endocrine Tumour, Shanghai Digital Medicine Innovation Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

¹⁴. MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom

¹⁵. Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China

¹⁶. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

¹⁷. Nanchang Research Institute, Sun Yat-Sen University, Nanchang, China

¹⁸. Department of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, Brazil

¹⁹. Department of Gastroenterology and Hepatology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

²⁰. Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China

²¹. Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China

²². Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China

²³. Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

²⁴. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China

²⁵. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China

²⁶. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, China

²⁷. Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China

²⁸. Anhui Key Laboratory of Geriatric Immunology and Nutrition Therapy, Hefei, China

²⁹. Department of Medicine, University of California San Diego, La Jolla, California, USA

chenhq@ccmu.edu.cn

yduan@ustc.edu.cn

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Yongpeng Shi, Zeran Chen, Tingyu Fang, Xingyao Chen, Youpeng Deng, Hao Qin, Min Lian, Juntao Shen, Yuru Zong, Huikuan Chu, Constanze Hoebinger, Hao Guo, Zhongshang Yuan, Jie Zheng, Yongjian Zhou, Yue Pan, Beatriz G. Mendes, Sonja Lang, Tim Hendrikx, Suling Zeng, Hailong Cao, Ling Yang, Lianmin Chen, Peng Chen, Lei Dai, Hua Wang, Shi Yin, Shu Zhu, Xiong Ma, Bernd Schnabl, Hanqing Chen, Yi Duan. Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities. iMeta, 2025, 4(1): e265 DOI:10.1002/imt2.265

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