Targeting SLC7A11/xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti-tumor immune response

Yuzhao Jin; Songhua Cai; Yang Zhou; Dandan Guo; Yuzhen Zeng; Wangting Xu; Yiting Sun; Yueli Shi; Zhiyong Xu; Zaoqu Liu; Peng Luo; Zhao Huang; Bufu Tang

doi:10.1002/imt2.248

iMeta ›› 2024, Vol. 3 ›› Issue (6) :e248 DOI: 10.1002/imt2.248

CORRESPONDENCE

Targeting SLC7A11/xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti-tumor immune response

Author information +

¹. Postgraduate Training Base, Wenzhou Medical University, Wenzhou, China

². Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China

³. Department of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China

⁴. Department of Oncology, First Affiliated Hospital, Dalian Medical University, Dalian, China

⁵. Department of Radiation Oncology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China

⁶. Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

⁷. Department of Clinical Medicine, China Medical University, Shenyang, China

⁸. Department of Respiratory and Critical Medicine, Center for Oncology Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu City, China

⁹. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

¹⁰. Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China

¹¹. Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

¹². Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

luopeng@smu.edu.cn

huangzhao@tjh.tjmu.edu.cn

tangbufu@zju.edu.cn

Show less

History +

PDF

Cite this article

Download citation ▾

Yuzhao Jin, Songhua Cai, Yang Zhou, Dandan Guo, Yuzhen Zeng, Wangting Xu, Yiting Sun, Yueli Shi, Zhiyong Xu, Zaoqu Liu, Peng Luo, Zhao Huang, Bufu Tang. Targeting SLC7A11/xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti-tumor immune response. iMeta, 2024, 3(6): e248 DOI:10.1002/imt2.248

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Nault, Jean-Charles, Olivier Sutter, Pierre Nahon, Nathalie Ganne-Carrié, and Olivier Séror. 2018. “Percutaneous Treatment of Hepatocellular Carcinoma: State of the Art and Innovations.” Journal of Hepatology 68: 783-797. https://doi.org/10.1016/j.jhep.2017.10.004

[2]

Llovet, Josep M., Thierry De Baere, Laura Kulik, Philipp K. Haber, Tim F. Greten, Tim Meyer, and Riccardo Lencioni. 2021. “Locoregional Therapies in the Era of Molecular and Immune Treatments for Hepatocellular Carcinoma.” Nature Reviews Gastroenterology & Hepatology 18: 293-313. https://doi.org/10.1038/s41575-020-00395-0

[3]	Kang, Tae Wook, Hyo Keun Lim, and Dong Ik Cha. 2017. “Aggressive Tumor Recurrence After Radiofrequency Ablation for Hepatocellular Carcinoma.” Clinical and Molecular Hepatology 23: 95-101. https://doi.org/10.3350/cmh.2017.0006

[4]

Shi, Liangrong, Lujun Chen, Changping Wu, Yibei Zhu, Bin Xu, Xiao Zheng, Mingfen Sun, et al. 2016. “PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor.” Clinical Cancer Research: An Official Journal of the American Association For Cancer Research 22: 1173-1184. https://doi.org/10.1158/1078-0432.CCR-15-1352

[5]	Palucka, Karolina, and Jacques Banchereau. 2012. “Cancer Immunotherapy via Dendritic Cells.” Nature Reviews Cancer 12: 265-277. https://doi.org/10.1038/nrc3258

[6]	Heras-Murillo, Ignacio, Irene Adán-Barrientos, Miguel Galán, Stefanie K. Wculek, and David Sancho. 2024. “Dendritic Cells as Orchestrators of Anticancer Immunity and Immunotherapy.” Nature Reviews Clinical Oncology 21: 257-277. https://doi.org/10.1038/s41571-024-00859-1

[7]

Qi, Xiaoqiang, Ming Yang, Lixin Ma, Madeline Sauer, Diego Avella, Jussuf T. Kaifi, Jeffrey Bryan, et al. 2020. “Synergizing Sunitinib and Radiofrequency Ablation to Treat Hepatocellular Cancer by Triggering the Antitumor Immune Response.” Journal For Immunotherapy of Cancer 8: e001038. https://doi.org/10.1136/jitc-2020-001038

[8]

Ali, Mona Y., Christian F. Grimm, Marcus Ritter, Leonhard Mohr, Hans-Peter Allgaier, Robert Weth, Wulf O. Bocher, et al. 2005. “Activation of Dendritic Cells By Local Ablation of Hepatocellular Carcinoma.” Journal of Hepatology 43: 817-822. https://doi.org/10.1016/j.jhep.2005.04.016. https://pubmed.ncbi.nlm.nih.gov/16087270

[9]	Glorieux, Christophe, Shihua Liu, Dunyaporn Trachootham, and Peng Huang. 2024. “Targeting ROS in Cancer: Rationale and Strategies.” Nature Reviews Drug Discovery 23: 583-606. https://doi.org/10.1038/s41573-024-00979-4

[10]

Arensman, Michael D., Xiaoran S. Yang, Danielle M. Leahy, Lourdes Toral-Barza, Mary Mileski, Edward C. Rosfjord, Fang Wang, et al. 2019. “Cystine-Glutamate Antiporter xCT Deficiency Suppresses Tumor Growth While Preserving Antitumor Immunity.” Proceedings of the National Academy of Sciences 116: 9533-9542. https://doi.org/10.1073/pnas.1814932116

[11]	Koppula, Pranavi, Yilei Zhang, Li Zhuang, and Boyi Gan. 2018. “Amino Acid Transporter SLC7A11/xCT at the Crossroads of Regulating Redox Homeostasis and Nutrient Dependency of Cancer.” Cancer Communications (London, England) 38: 12. https://doi.org/10.1186/s40880-018-0288-x

[12]	Yan, Yuelong, Hongqi Teng, Qinglei Hang, Lavanya Kondiparthi, Guang Lei, Amber Horbath, Xiaoguang Liu, et al. 2023. “SLC7A11 Expression Level Dictates Differential Responses to Oxidative Stress in Cancer Cells.” Nature Communications 14: 3673. https://doi.org/10.1038/s41467-023-39401-9

[13]	Maier, Barbara, Andrew M. Leader, Steven T. Chen, Navpreet Tung, Christie Chang, Jessica LeBerichel, Aleksey Chudnovskiy, et al. 2020. “A Conserved Dendritic-Cell Regulatory Program Limits Antitumour Immunity.” Nature 580: 257-262. https://doi.org/10.1038/s41586-020-2134-y

[14]

Magen, Assaf, Pauline Hamon, Nathalie Fiaschi, Brian Y. Soong, Matthew D. Park, Raphaël Mattiuz, Etienne Humblin, et al. 2023. “Intratumoral Dendritic cell-CD4+ T Helper Cell Niches Enable CD8+ T Cell Differentiation Following PD-1 Blockade in Hepatocellular Carcinoma.” Nature Medicine 29: 1389-1399. https://doi.org/10.1038/s41591-023-02345-0