Novel microbial modifications of bile acids and their functional implications

References

[1] Ridlon, Jason M., and H. Rex Gaskins. 2024. “Another Renaissance for Bile Acid Gastrointestinal Microbiology.” Nature Reviews Gastroenterology & Hepatology 21: 348-364. https://doi.org/10.1038/s41575-024-00896-2

[2] Quinn, Robert A., Alexey V. Melnik, Alison Vrbanac, Ting Fu, Kathryn A. Patras, Mitchell P. Christy, Zsolt Bodai, et al. 2020. “Global Chemical Effects of the Microbiome Include New Bile-Acid Conjugations.” Nature 579: 123-129. https://doi.org/10.1038/s41586-020-2047-9

[3] Zheng, Xiaojiao, Tianlu Chen, Aihua Zhao, Zhangchi Ning, Junliang Kuang, Shouli Wang, Yijun You, et al. 2021. “Hyocholic Acid Species as Novel Biomarkers for Metabolic Disorders.” Nature Communications 12: 1487. https://doi.org/10.1038/s41467-021-21744-w

[4] Zheng, Xiaojiao, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, et al. 2021. “Hyocholic Acid Species Improve Glucose Homeostasis through a Distinct TGR5 and FXR Signaling Mechanism.” Cell Metabolism 33: 791-803.e7. https://doi.org/10.1016/j.cmet.2020.11.017

[5] Makki, Kassem, Harald Brolin, Natalia Petersen, Marcus Henricsson, Dan Ploug Christensen, Muhammad Tanweer Khan, Annika Wahlström, et al. 2023. “6α-Hydroxylated Bile Acids Mediate TGR5 Signalling to Improve Glucose Metabolism Upon Dietary Fiber Supplementation in Mice.” Gut 72: 314-324. https://doi.org/10.1136/gutjnl-2021-326541

[6] Kuang, Junliang, Jieyi Wang, Yitao Li, Mengci Li, Mingliang Zhao, Kun Ge, Dan Zheng, et al. 2023. “Hyodeoxycholic Acid Alleviates Non-Alcoholic Fatty Liver Disease through Modulating the Gut-Liver Axis.” Cell Metabolism 35: 1752-1766.e8. https://doi.org/10.1016/j.cmet.2023.07.011

[7] Zhong, Jing, Xiaofang He, Xinxin Gao, Qiaohong Liu, Yu Zhao, Ying Hong, Weize Zhu, et al. 2023. “Hyodeoxycholic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting RAN-mediated PPARα Nucleus-Cytoplasm Shuttling.” Nature Communications 14: 5451. https://doi.org/10.1038/s41467-023-41061-8

[8] Rimal, Bipin, Stephanie L. Collins, Ceylan E. Tanes, Edson R. Rocha, Megan A. Granda, Sumeet Solanki, Nushrat J. Hoque, et al. 2024. “Bile Salt Hydrolase Catalyses Formation of Amine-Conjugated Bile Acids.” Nature 626: 859-863. https://doi.org/10.1038/s41586-023-06990-w

[9] Guzior, Douglas V., Maxwell Okros, Madison Shivel, Bruin Armwald, Christopher Bridges, Yousi Fu, Christian Martin, et al. 2024. “Bile Salt Hydrolase Acyltransferase Activity Expands Bile Acid Diversity.” Nature 626: 852-858. https://doi.org/10.1038/s41586-024-07017-8

[10] Gentry, Emily C., Stephanie L. Collins, Morgan Panitchpakdi, Pedro Belda-Ferre, Allison K. Stewart, Marvic Carrillo Terrazas, Hsueh-han Lu, et al. 2023. “Reverse Metabolomics for the Discovery of Chemical Structures from Humans.” Nature 626: 419-426. https://doi.org/10.1038/s41586-023-06906-8

[11] Mohanty, Ipsita, Helena Mannochio-Russo, Joshua V. Schweer, Yasin El Abiead, Wout Bittremieux, Shipei Xing, Robin Schmid, et al. 2024. “The Underappreciated Diversity of Bile Acid Modifications.” Cell 187: 1801-1818.e20. https://doi.org/10.1016/j.cell.2024.02.019

[12] Liu, Chang, Meng-Xuan Du, Li-Sheng Xie, Wen-Zhao Wang, Bao-Song Chen, Chu-Yu Yun, Xin-Wei Sun, et al. 2024. “Gut Commensal Christensenella minuta Modulates Host Metabolism via Acylated Secondary Bile Acids.” Nature Microbiology 9: 434-450. https://doi.org/10.1038/s41564-023-01570-0

[13] Nie, Qixing, Xi Luo, Kai Wang, Yong Ding, Shumi Jia, Qixiang Zhao, Meng Li, et al. 2024. “Gut Symbionts Alleviate MASH through a Secondary Bile Acid Biosynthetic Pathway.” Cell 187: 2717-2734.e33. https://doi.org/10.1016/j.cell.2024.03.034

[14] Garcia, Carlos J., Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, and Jana Hajslova. 2022. “Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota.” Biomolecules 12: 687. https://doi.org/10.3390/biom12050687

[15] Funabashi, Masanori, Tyler L. Grove, Min Wang, Yug Varma, Molly E. McFadden, Laura C. Brown, Chunjun Guo, et al. 2020. “A Metabolic Pathway for Bile Acid Dehydroxylation by the Gut Microbiome.” Nature 582: 566-570. https://doi.org/10.1038/s41586-020-2396-4

[16] Zhang, Chenguang, Huifeng Liu, Lei Sun, Yue Wang, Xiaodong Chen, Juan Du, Åsa Sjöling, Junhu Yao, and Shengru Wu. 2023. “An Overview of Host-Derived Molecules that Interact with Gut Microbiota.” iMeta 2: e88. https://doi.org/10.1002/imt2.88

[17] Li, Jiaxin, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, et al. 2023. “Gut Microbial Metabolite Hyodeoxycholic Acid Targets the TLR4/MD2 Complex to Attenuate Inflammation and Protect against Sepsis.” Molecular Therapy 31: 1017-1032. https://doi.org/10.1016/j.ymthe.2023.01.018

[18] Zhu, Han, Yuyan Bai, Gaorui Wang, Yousong Su, Yanlin Tao, Lupeng Wang, Liu Yang, et al. 2022. “Hyodeoxycholic Acid Inhibits Lipopolysaccharide-Induced Microglia Inflammatory Responses through Regulating TGR5/AKT/NF-κB Signaling Pathway.” Journal of Psychopharmacology 36: 849-859. https://doi.org/10.1177/02698811221089041

[19] Shen, Shuang, Dan Huang, Shengnan Qian, Xin Ye, Qian Zhuang, Xinjian Wan, and Zhixia Dong. 2023. “Hyodeoxycholic Acid Attenuates Cholesterol Gallstone Formation via Modulation of Bile Acid Metabolism and Gut Microbiota.” European Journal of Pharmacology 955: 175891. https://doi.org/10.1016/j.ejphar.2023.175891

[20] Zhang, Zeping, Boyan Zhang, Xianzhe Jiang, Yue Yu, Yimeng Cui, Hailing Luo, and Bing Wang. 2023. “Hyocholic Acid Retards Renal Fibrosis by Regulating Lipid Metabolism and Inflammatory Response in a Sheep Model.” International Immunopharmacology 122: 110670. https://doi.org/10.1016/j.intimp.2023.110670

RIGHTS & PERMISSIONS

2024 The Author(s). iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.