The challenge and opportunity of gut microbiota-targeted nanomedicine for colorectal cancer therapy

References

[1] Cui, Weiwei, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Y. Yang, Haidi Huang, Chunhui Liang, et al. 2024. “Gut Microbial Metabolite Facilitates Colorectal Cancer Development Via Ferroptosis Inhibition.” Nature Cell Biology 26: 124-137. https://doi.org/10.1038/s41556-023-01314-6

[2] Wong, Chi Chun, and Jun Yu. 2023. “Gut Microbiota in Colorectal Cancer Development and Therapy.” Nature Reviews Clinical Oncology 20: 429-452. https://doi.org/10.1038/s41571-023-00766-x

[3] Qin, Yuting, Ruifang Zhao, Hao Qin, Long Chen, Hanqing Chen, Yuliang Zhao, and Guangjun Nie. 2021. “Colonic Mucus-Accumulating Tungsten Oxide Nanoparticles Improve the Colitis Therapy by Targeting Enterobacteriaceae.” Nano Today 39: 101234. https://doi.org/10.1016/j.nantod.2021.101234

[4] Liu, Hongyu, Yunjian Yu, Alideertu Dong, Mahmoud Elsabahy, Ying-Wei Yang, and Hui Gao. 2023 “Emerging Strategies for Combating Fusobacterium Nucleatum in Colorectal Cancer Treatment: Systematic Review, Improvements and Future Challenges.” Exploration 4: 20230092. https://doi.org/10.1002/exp.20230092

[5] Wu, Shenshen, Jun Yun, Weiyan Tang, Giuseppe Familiari, Michela Relucenti, Jiong Wu, Xiaobo Li, Hanqing Chen, and Rui Chen. 2023. “Therapeutic M6a Eraser Alkbh5 mRNA-Loaded Exosome-Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models.” ACS Nano 17: 11838-11854. https://doi.org/10.1021/acsnano.3c03050

[6] Wu, Shenshen, Jiajia Wang, Zan Fu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xiaobo Li, Hanqing Chen, and Rui Chen. 2023. “Matairesinol Nanoparticles Restore Chemosensitivity and Suppress Colorectal Cancer Progression in Preclinical Models: Role of Lipid Metabolism Reprogramming.” Nano Letters 23: 1970-1980. https://doi.org/10.1021/acs.nanolett.3c00035

[7] Saeed, Mohd, Ambreen Shoaib, Raghuram Kandimalla, Shamama Javed, Ahmad Almatroudi, Ramesh Gupta, and Farrukh Aqil. 2022. “Microbe-Based Therapies for Colorectal Cancer: Advantages and Limitations.” Seminars in Cancer Biology 86: 652-665. https://doi.org/10.1016/j.semcancer.2021.05.018

[8] Chen, Linfu, Rui Zhao, Jingjing Shen, Nanhui Liu, Zixuan Zheng, Yu Miao, Jiafei Zhu, et al. 2023. “Antibacterial Fusobacterium Nucleatum-Mimicking Nanomedicine to Selectively Eliminate Tumor-Colonized Bacteria and Enhance Immunotherapy Against Colorectal Cancer.” Advanced Materials 35: 2306281. https://doi.org/10.1002/adma.202306281

[9] Dong, Xue, Pei Pan, Di-Wei Zheng, Peng Bao, Xuan Zeng, and Xian-Zheng Zhang. 2020. “Bioinorganic Hybrid Bacteriophage for Modulation of Intestinal Microbiota to Remodel Tumor-Immune Microenvironment Against Colorectal Cancer.” Science Advances 6: eaba1590. https://doi.org/10.1126/sciadv.aba1590

[10] Zheng, Di-Wei, Xue Dong, Pei Pan, Ke-Wei Chen, Jin-Xuan Fan, Si-Xue Cheng, and Xian-Zheng Zhang. 2019. “Phage-Guided Modulation of the Gut Microbiota of Mouse Models of Colorectal Cancer Augments Their Responses to Chemotherapy.” Nature Biomedical Engineering 3: 717-728. https://doi.org/10.1038/s41551-019-0423-2

[11] Jiang, Han, Yuedong Guo, Zhiguo Yu, Ping Hu, and Jianlin Shi. 2022. “Nanocatalytic Bacteria Disintegration Reverses Immunosuppression of Colorectal Cancer.” National Science Review 9: nwac169. https://doi.org/10.1093/nsr/nwac169

[12] Chen, Zhao-Xia, Jiang-Lan Li, Pei Pan, Peng Bao, Xuan Zeng, and Xian-Zheng Zhang. 2021. “Combination Gut Microbiota Modulation and Chemotherapy for Orthotopic Colorectal Cancer Therapy.” Nano Today 41: 101329. https://doi.org/10.1016/j.nantod.2021.101329

[13] Wang, Menglin, Benoit Rousseau, Kunyu Qiu, Guannan Huang, Yu Zhang, Hang Su, Christine Le Bihan-Benjamin, et al. 2023. “Killing Tumor-Associated Bacteria With a Liposomal Antibiotic Generates Neoantigens That Induce Anti-Tumor Immune Responses.” Nature Biotechnology : 1-12. In press. https://doi.org/10.1038/s41587-023-01957-8

[14] Zheng, Di-Wei, Run-Qing Li, Jia-Xin An, Tian-Qiu Xie, Zi-Yi Han, Rui Xu, Yu Fang, and Xian-Zheng Zhang. 2020. “Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer.” Advanced Materials 32: e2004529. https://doi.org/10.1002/adma.202004529

[15] Lang, Tianqun, Runqi Zhu, Xiao Zhu, Wenlu Yan, Yu Li, Yihui Zhai, Ting Wu, et al. 2023. “Combining Gut Microbiota Modulation and Chemotherapy by Capecitabine-Loaded Prebiotic Nanoparticle Improves Colorectal Cancer Therapy.” Nature Communications 14: 4746. https://doi.org/10.1038/s41467-023-40439-y

[16] Gurbatri, Candice R., Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, et al. 2024. “Engineering Tumor-Colonizing E. Coli Nissle 1917 for Detection and Treatment of Colorectal Neoplasia.” Nature Communications 15: 646. https://doi.org/10.1038/s41467-024-44776-4

[17] Zepeda-Rivera, Martha, Samuel S. Minot, Heather Bouzek, Hanrui Wu, Aitor Blanco-Míguez, Paolo Manghi, Dakota S. Jones, et al. 2024. “A Distinct Fusobacterium Nucleatum Clade Dominates the Colorectal Cancer Niche.” Nature 628: 424-432. https://doi.org/10.1038/s41586-024-07182-w

[18] Gao, Chunxiao, Xijun Wang, Bing Yang, Wei Yuan, Wei Huang, Guoju Wu, and Jie Ma. 2023. “Synergistic Target of Intratumoral Microbiome and Tumor by Metronidazole-Fluorouridine Nanoparticles.” ACS Nano 17: 7335-7351. https://doi.org/10.1021/acsnano.2c11305

[19] Wang, Zhi-Hao, Wanting Huang, Shuhao Zhang, Mengyu Chu, Na Yin, Chaoran Zhu, Zhenzhong Zhang, Jinjin Shi, and Junjie Liu. 2023. “Self-Thermophoretic Nanoparticles Enhance Intestinal Mucus Penetration and Reduce Pathogenic Bacteria Interception in Colorectal Cancer.” Advanced Functional Materials 33: 2212013. https://doi.org/10.1002/adfm.202212013

[20] An, Byung Chull, Yongku Ryu, Yeo-Sang Yoon, Oksik Choi, Ho Jin Park, Tai Yeub Kim, Song-In Kim, Bong-Kyu Kim, and Myung Jun Chung. 2019. “Colorectal Cancer Therapy Using a Pediococcus Pentosaceus Sl4 Drug Delivery System Secreting Lactic Acid Bacteria-Derived Protein P8.” Molecules and Cells 42: 755-762. https://doi.org/10.14348/molcells.2019.0064

RIGHTS & PERMISSIONS

2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.