Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy

Lamei Wang; Javier A. Villafuerte Gálvez; Christina Lee; Shengru Wu; Ciaran P. Kelly; Xinhua Chen; Yangchun Cao

doi:10.1002/imt2.200

iMeta ›› 2024, Vol. 3 ›› Issue (3) : 200 DOI: 10.1002/imt2.200

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Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy

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Abstract

•The progression of Clostridioides difficile infection (CDI) is influenced by various factors, including the use of antibiotics, age, comorbidities, immune gene polymorphisms, and antibody levels.

•Immune response plays a critical role in controlling both the course and severity of CDI.

•Immunotherapy holds significant promise for advancing both treatment and prevention strategies for CDI. This encompasses the application of monoclonal antibodies, vaccines, and fecal microbiota transplantation (FMT).

Keywords

antibody / Clostridium difficile / gut microbiota / host immune / toxins

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Lamei Wang,Javier A. Villafuerte Gálvez,Christina Lee,Shengru Wu,Ciaran P. Kelly,Xinhua Chen,Yangchun Cao. Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy. iMeta, 2024, 3(3): 200 DOI:10.1002/imt2.200