A new evaluation system for drug–microbiota interactions
Tian-Hao Liu , Chen-Yang Zhang , Hang Zhang , Jing Jin , Xue Li , Shi-Qiang Liang , Yu-Zheng Xue , Feng-Lai Yuan , Ya-Hong Zhou , Xiu-Wu Bian , Hong Wei
iMeta ›› 2024, Vol. 3 ›› Issue (3) : 199
A new evaluation system for drug–microbiota interactions
•Shaped by both genetic and environmental factors, gut microbiota significantly influences the host’s drug absorption, distribution, metabolism, and excretion (ADME) microenvironment, highlighting the need for a new evaluation system for drug-microbiome interactions. •To investigate the intricate nature of interactions between gut microbiota and drugs in vivo, a novel top-down research approach utilizing germ-free animal models is proposed.
drug metabolism / drug–microbiota interactions / genetic and environmental factors / gut microbiota
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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