Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer
Wei Chong , Huicheng Ren , Hao Chen , Kang Xu , Xingyu Zhu , Yuan Liu , Yaodong Sang , Han Li , Jin Liu , Chunshui Ye , Liang Shang , Changqing Jing , Leping Li
iMeta ›› 2024, Vol. 3 ›› Issue (3) : 190
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer
•Four distinct cuproptosis signature-based clusters are associated with different clinical outcomes and biological pathways and are highly consistent with distinct tumor immune contextures, respectively. •Based on the cuproptosis signature risk score, GC patients with a higher CSRS score were characterized by decreased survival time and correlated with tumor adhesion state and lower tumor mutation loads. •DBT, MTF1, or ATP7A were significantly elevated in the CSRS-High subtype, while ATP7B, SLC31A1, GCSH, LIAS, DLAT, FDX1, DLD, and PDHA1 were increased in the CSRS-Low subtype. •Drug sensitivity analyses revealed potential therapeutic compounds for GC with high CSRS scores.
clinical features / cuproptosis / gastric cancer / molecular landscape / prognosis model
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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