Unraveling interindividual variation of trimethylamine N-oxide and its precursors at the population level
Sergio Andreu-Sánchez , Shahzad Ahmad , Alexander Kurilshikov , Marian Beekman , Mohsen Ghanbari , Martijn van Faassen , Inge C. L. van den Munckhof , Marinka Steur , Amy Harms , Thomas Hankemeier , M. Arfan Ikram , Maryam Kavousi , Trudy Voortman , Robert Kraaij , Mihai G. Netea , Joost H. W. Rutten , Niels P. Riksen , Alexandra Zhernakova , Folkert Kuipers , P. Eline Slagboom , Cornelia M. van Duijn , Jingyuan Fu , Dina Vojinovic
iMeta ›› 2024, Vol. 3 ›› Issue (3) : 183
Unraveling interindividual variation of trimethylamine N-oxide and its precursors at the population level
•Exploration of microbiome-related metabolites (trimethylamine N-oxide [TMAO], choline, betaine, L-carnitine, and deoxycarnitine) in 7834 participants from five population cohorts. •Cardiovascular risk was associated with elevated choline concentrations, but not with TMAO concentrations. •Characterization of the genetic architecture behind metabolite concentration variability. •Identification of gut microbial taxonomic abundance associated with metabolite’s plasma concentration levels. •Fish intake is the major dietary driver of TMAO concentrations, and betaine is related to grains and vegetable intake.
diet / genetics / gut microbiome / meta-analysis / population cohort / TMAO
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
/
| 〈 |
|
〉 |
PDF
