Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway
Ling Wang , Yi-Xuan Tu , Lu Chen , Ke-Chun Yu , Hong-Kai Wang , Shu-Qiao Yang , Yuan Zhang , Shuai-Jie Zhang , Shuo Song , Hong-Li Xu , Zhu-Cheng Yin , Ming-Qian Feng , Jun-Qiu Yue , Xiang-Hong Huang , Tang Tang , Shao-Zhong Wei , Xin-Jun Liang , Zhen-Xia Chen
iMeta ›› 2024, Vol. 3 ›› Issue (1) : 165
Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway
•The black rice diet (BRD) can slow down the development of colorectal tumors in ApcMin/+ and azoxymethane/dextran sulfate sodium (AOM/DSS) colorectal cancer (CRC) model mice. •The BRD increases the abundance of intestinal probiotics, such as Bacteroides uniformis and Lactobacillus, while reducing potential intestinal pathogens. •The upregulated metabolites indole and indole-3-lactic acid in BRD are ligands of the aryl hydrocarbon receptor (AHR) pathway, which slow down the development of CRC by activating intestinal AHR receptor gene expression. •A moderate consumption of BRD is expected to become a potential strategy for the prevention and treatment of CRC by improving gut microbiota and metabolites.
black rice diet / colorectal cancer / gut metabolites / gut microbiome
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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