Glucomannan promotes Bacteroides ovatus to improve intestinal barrier function and ameliorate insulin resistance
Qixing Nie , Yonggan Sun , Wenbing Hu , Chunhua Chen , Qiongni Lin , Shaoping Nie
iMeta ›› 2024, Vol. 3 ›› Issue (1) : 163
Glucomannan promotes Bacteroides ovatus to improve intestinal barrier function and ameliorate insulin resistance
•Supplementation with glucomannan alleviates insulin resistance. •Glucomannan promotes the growth of Bacteroides ovatus, accompanied by improved intestinal barrier integrity and reduced systemic inflammation. •B. ovatus-derived indoleacetic acid is a key bioactive metabolite that fortifies intestinal barrier function via the activation of intestinal aryl hydrocarbon receptor.
aryl hydrocarbon receptor / B. ovatus / glucomannan / indoleacetic acid
2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
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