Daily occupational exposure in swine farm alters human skin microbiota and antibiotic resistome

Dong-Rui Chen; Ke Cheng; Lei Wan; Chao-Yue Cui; Gong Li; Dong-Hao Zhao; Yang Yu; Xiao-Ping Liao; Ya-Hong Liu; Alaric W. D’Souza; Xin-Lei Lian; Jian Sun

doi:10.1002/imt2.158

iMeta ›› 2024, Vol. 3 ›› Issue (1) : 158 DOI: 10.1002/imt2.158

RESEARCH ARTICLE

Daily occupational exposure in swine farm alters human skin microbiota and antibiotic resistome

Dong-Rui Chen ¹^,²^,³^,⁴^,⁵
, Ke Cheng ⁵
, Lei Wan ¹^,²^,³^,⁴
, Chao-Yue Cui ⁶
, Gong Li ¹^,²^,³^,⁴
, Dong-Hao Zhao ¹^,²^,³^,⁴
, Yang Yu ¹^,²^,³^,⁴
, Xiao-Ping Liao ¹^,²^,³^,⁴
, Ya-Hong Liu ¹^,²^,³^,⁴
, Alaric W. D’Souza ⁷^,⁸^,^†
, Xin-Lei Lian ¹^,²^,³^,^†
, Jian Sun ¹^,²^,³^,⁴^,^†

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Abstract

•Exposure to livestock-associated environment, more microbially enriched than school environment, can remodel the human skin microbiome and antibiotic resistome.

•The 5 h of exposure is sufficient to alter the microbiota and antibiotic resistance genes (ARGs) structure of skin and these changes were retained once formed.

•ARGs carried by host microbes were transferred between the environment and workers’ skin.

Keywords

antibiotic resistome / metagenomic sequencing / occupational exposure / skin microbiota / swine farm

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Dong-Rui Chen, Ke Cheng, Lei Wan, Chao-Yue Cui, Gong Li, Dong-Hao Zhao, Yang Yu, Xiao-Ping Liao, Ya-Hong Liu, Alaric W. D’Souza, Xin-Lei Lian, Jian Sun. Daily occupational exposure in swine farm alters human skin microbiota and antibiotic resistome. iMeta, 2024, 3(1): 158 DOI:10.1002/imt2.158