Beneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review

Alessio Calabrò , Anna Caterina Procopio , Francesco Primerano , Tiziana Larussa , Francesco Luzza , Laura Di Renzo , Antonino De Lorenzo , Paola Gualtieri , Ludovico Abenavoli

Hepatoma Research ›› 2020, Vol. 6 : 69

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Hepatoma Research ›› 2020, Vol. 6:69 DOI: 10.20517/2394-5079.2020.63
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Beneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is related to unhealthy lifestyle habits, characterized by a diet rich in sugars and fats leading to excessive calorie intake, and lack of exercise. In recent years, there is a growing incidence of this pathology, raising the attention of hepatologists, endocrinologists, diabetologists, and nutritionists. In this context, the alimentary regimen adopted by patients with NAFLD has become an increasingly scrutinised parameter. Diet is now considered a crucial factor in the treatment of NAFLD since it has been observed that some functional foods play a beneficial role. These include coffeewhose health effects have already been amply demonstrated. Here we describe the beneficial effects of coffee consumption reported in the NAFLD literature.

Keywords

Caffeine / steatosis / functional food / liver disease / antioxidant / chlorogenic-acid

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Alessio Calabrò, Anna Caterina Procopio, Francesco Primerano, Tiziana Larussa, Francesco Luzza, Laura Di Renzo, Antonino De Lorenzo, Paola Gualtieri, Ludovico Abenavoli. Beneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review. Hepatoma Research, 2020, 6: 69 DOI:10.20517/2394-5079.2020.63

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References

[1]

Asrani SK,Eaton J.Burden of liver diseases in the world..J Hepatol2019;70:151-71

[2]

Abenavoli L,Medić-Stojanoska M.Non-alcoholic fatty liver disease and primary care physicians..Minerva Gastroenterol Dietol2020;66:4-5

[3]

Abenavoli L,Milić N,Giuffrè AM.Olive oil antioxidants and non-alcoholic fatty liver disease..Expert Rev Gastroenterol Hepatol2019;13:739-49

[4]

Rinella M.The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health..Hepatology2016;64:19-22

[5]

Abenavoli L,Milic N.Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series..Ann Hepatol2015;14:121-6

[6]

Michel M.Effectiveness of lifestyle interventions in NAFLD (nonalcoholic fatty liver disease) - how are clinical trials affected?.Expert Opin Investig Drugs2020;29:93-7

[7]

Lonardo A,Lugari S.NAFLD in some common endocrine diseases: prevalence, pathophysiology, and principles of diagnosis and management..Int J Mol Sci2019;20:2841 PMCID:PMC6600657

[8]

Gelli C,Abenavoli L,Galli A.Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease..World J Gastroenterol2017;23:3150-62 PMCID:PMC5423052

[9]

Abenavoli L,Procopio AC,Maruca G.Ancient wheats: beneficial effects on insulin resistance..Minerva Med2020;Jul 28[Online ahead of print]

[10]

Brunner KT,Wilechansky RM.Nonalcoholic Fatty Liver Disease and Obesity Treatment..Curr Obes Rep2019;8:220-8 PMCID:PMC6770992

[11]

Hamurcu Varol P,Alphan E.Role of intensive dietary and lifestyle interventions in the treatment of lean nonalcoholic fatty liver disease patients..Eur J Gastroenterol Hepatol2020;32:1352-7

[12]

Cai J,Li H.Progress and challenges in the prevention and control of nonalcoholic fatty liver disease..Med Res Rev2019;39:328-48

[13]

Abenavoli L,Boccuto L,Gratteri S.Health benefits of Mediterranean diet in nonalcoholic fatty liver disease..Expert Rev Gastroenterol Hepatol2018;12:873-81

[14]

Abenavoli L,Federico A,Loguercio C.Diet and non-alcoholic fatty liver disease: the mediterranean way..Int J Environ Res Public Health2019;16:3011 PMCID:PMC6747511

[15]

Abenavoli L,Luzza F,De Lorenzo A.Polyphenols Treatment in Patients with Nonalcoholic Fatty Liver Disease..J Transl Int Med2017;5:144-7 PMCID:PMC5688531

[16]

Abenavoli L,Di Renzo L,Medić-Stojanoska M.Metabolic aspects of adult patients with nonalcoholic fatty liver disease..World J Gastroenterol2016;22:7006-16 PMCID:PMC4988304

[17]

Di Renzo L,Bernardini S,Aiello V.A hazelnut-enriched diet modulates oxidative stress and inflammation gene expression without weight gain..Oxid Med Cell Longev2019;2019:4683723 PMCID:PMC6637671

[18]

Araújo AR,Bedogni G,Bellentani S.Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: what we need in the future..Liver Int.2018;38 Suppl 1:47-51

[19]

Luk JM,Liu P,Chan KL.Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation..Liver Int2007;27:879-90

[20]

Philips CA,Rajesh S,Madhu D.Complementary and alternative medicine-related drug-induced liver injury in Asia..J Clin Transl Hepatol2019;7:263-74 PMCID:PMC6783675

[21]

Richmond JA,Patel K,Muir A.The use of complementary and alternative medicine by patients with chronic hepatitis C..Complement Ther Clin Pract2010;16:124-31

[22]

Henson JB,Chow SC.Complementary and alternative medicine use in United States adults with liver disease..J Clin Gastroenterol2017;51:564-70 PMCID:PMC7245507

[23]

Nieber K.The impact of coffee on health..Planta Med2017;83:1256-63

[24]

Costa J,Santos C,Vaz-Carneiro A.Caffeine exposure and the risk of Parkinson’s disease: a systematic review and meta-analysis of observational studies..J Alzheimers Dis.2010;20 Suppl 1:S221-38

[25]

Crippa A,Larsson SC,Orsini N.Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis..Am J Epidemiol2014;180:763-75

[26]

Nordestgaard AT,Nordestgaard BG.Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study..J Intern Med2020;287:42-53

[27]

Lopez-Garcia E,Li TY,Hu FB.The relationship of coffee consumption with mortality..Ann Intern Med2008;148:904-14 PMCID:PMC3958951

[28]

Freedman ND,Abnet CC,Sinha R.Association of coffee drinking with total and cause-specific mortality..N Engl J Med2012;366:1891-904 PMCID:PMC3439152

[29]

Nehlig A,Debry G.Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects..Brain Res Rev1992;17:139-70

[30]

Shim SG,Kim EK,Lee KN.Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model..J Gastroenterol Hepatol2013;28:1877-84

[31]

Gressner OA,Rehbein K,Weiskirchen R.Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways..J Hepatol2008;49:758-67

[32]

Quan HY,Chung SH.Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells..BMB Rep2013;46:207-12 PMCID:PMC4133884

[33]

Helal MG,Elkashefand WF.Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention..Hum Exp Toxicol2018;37:983-90

[34]

Perumpail BJ,Iqbal U,Shah ND.Potential therapeutic benefits of Herbs and supplements in patients with NAFLD..Diseases2018;6:80 PMCID:PMC6165515

[35]

Watanabe S,Ogawa H,Tsunematsu T.Daily coffee intake inhibits pancreatic beta cell damage and nonalcoholic steatohepatitis in a mouse model of spontaneous metabolic syndrome, tsumura-suzuki obese diabetic mice..Metab Syndr Relat Disord2017;15:170-7

[36]

Di Renzo L,Carraro A,Gualtieri P.Changes in LDL oxidative status and oxidative and inflammatory gene expression after red wine intake in healthy people: a randomized trial..Mediators Inflamm2015;2015:317348 PMCID:PMC4458536

[37]

Colica C,Trombetta D,Bernardini S.Antioxidant effects of a hydroxytyrosol-based pharmaceutical formulation on body composition, metabolic state, and gene expression: a randomized double-blinded, placebo-controlled crossover trial..Oxid Med Cell Longev2017;2017:2473495 PMCID:PMC5569630

[38]

Meng S,Feng Q,Hu Y.Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review..Evid Based Complement Alternat Med2013;2013:801457 PMCID:PMC3766985

[39]

Zduńska K,Kolodziejczak A.Antioxidant properties of ferulic acid and its possible application..Skin Pharmacol Physiol2018;31:332-6

[40]

Sarwar T,Husain MA,Rehman SU.Redox cycling of endogenous copper by ferulic acid leads to cellular DNA breakage and consequent cell death: A putative cancer chemotherapy mechanism..Toxicol Appl Pharmacol2015;289:251-61

[41]

Hosseinabadi S,Asghari S,Vojouhi S.Effect of green coffee extract supplementation on serum adiponectin concentration and lipid profile in patients with non-alcoholic fatty liver disease: a randomized, controlled trial..Complement Ther Med2020;49:102290

[42]

Graeter T,Mason RA,Haenle MM.Coffee consumption and NAFLD: a community based study on 1223 subjects..BMC Res Notes2015;8:640 PMCID:PMC4632464

[43]

Bambha K,Unalp A,Neuschwander-Tetri BA.Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis..Liver Int2014;34:1250-8 PMCID:PMC4010559

[44]

Anty R,Iannelli A,Schneck AS.Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery..J Hepatol2012;57:1090-6

[45]

Zelber-Sagi S,Webb M,Yeshua H.Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population..Transl Res2015;165:428-36

[46]

Hodge A,Goh E,Marsh P.Coffee intake is associated with a lower liver stiffness in patients with non-alcoholic fatty liver disease, Hepatitis C, and Hepatitis B..Nutrients2017;9:56 PMCID:PMC5295100

[47]

Alferink LJM,Kiefte-de Jong JC,Hansen BE.Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: the Rotterdam study..J Hepatol2017;67:339-48

[48]

Furtado KS,Aguiar E,Dias MC.Coffee and caffeine protect against liver injury induced by thioacetamide in male Wistar rats..Basic Clin Pharmacol Toxicol2012;111:339-47

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