Frailty and Liver resection: where do we stand?

Georgios S. Sioutas , Ioannis A. Ziogas , Georgios Tsoulfas

Hepatoma Research ›› 2020, Vol. 6 : 4

PDF
Hepatoma Research ›› 2020, Vol. 6:4 DOI: 10.20517/2394-5079.2019.43
Review
Review

Frailty and Liver resection: where do we stand?

Author information +
History +
PDF

Abstract

As the world population is continuously aging, the number of older patients requiring liver surgery is also on the rise. Data have shown that age should not be a limiting factor for liver resection, as it cannot accurately predict postoperative outcomes. Instead, frailty can serve as a more reliable measure of the patient’s overall health and functional reserves. Several frailty assessment tools have been implemented for preoperative risk stratification before liver surgery, and higher scores have commonly been associated with postoperative morbidity, mortality, and length of hospital stay. However, no consensus has been reached on the most useful screening tool. Future studies should focus on comparing the currently available assessment tools, constructing a liver resection-specific tool, and assessing the role of frailty assessment tools in preoperative patient optimization.

Keywords

Frailty / age / elderly / liver resection / liver surgery / morbidity / morbidity / complications

Cite this article

Download citation ▾
Georgios S. Sioutas, Ioannis A. Ziogas, Georgios Tsoulfas. Frailty and Liver resection: where do we stand?. Hepatoma Research, 2020, 6: 4 DOI:10.20517/2394-5079.2019.43

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Tsukioka G,Sohara N,Takagi H.Hepatocellular carcinoma in extremely elderly patients: an analysis of clinical characteristics, prognosis and patient survival..World J Gastroenterol2006;12:48-53 PMCID:PMC4077478

[2]

Cho SW,Tsung A,Geller DA.Safety of liver resection in the elderly: how important is age?.Ann Surg Oncol2011;18:1088-95

[3]

Nanashima A,Nonaka T,Hidaka S.Prognosis of patients with hepatocellular carcinoma after hepatic resection: are elderly patients suitable for surgery?.J Surg Oncol2011;104:284-91

[4]

Shirabe K,Harimoto N,Tsujita E.Early outcome following hepatic resection in patients older than 80 years of age..World J Surg2009;33:1927-32

[5]

Oishi K,Kobayashi T,Amano H.Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more..J Gastrointest Surg2009;13:695-701

[6]

Huang J,Chen GH,Zhang YQ.Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy..J Gastrointest Surg2009;13:1627-35

[7]

Lee CW,Tsai HI,Lin CY.Hepatic resection for hepatocellular carcinoma in the octogenarian: is it justified?.Aging (Albany NY)2019;11:1537-50 PMCID:PMC6428089

[8]

Wu FH,Luo SC,Chao WS.Liver resection for hepatocellular carcinoma in oldest old patients..World J Surg Oncol2019;17:1 PMCID:PMC6317186

[9]

Oishi K,Kohashi T,Nakahara H.Safety of hepatectomy for elderly patients with hepatocellular carcinoma..World J Gastroenterol2014;20:15028-36 PMCID:PMC4223236

[10]

Jansen PLM.Liver disease in the elderly..Best Pract Res Clin Gastroenterol2002;16:149-58

[11]

Michalopoulos GK.Liver regeneration..J Cell Physiol2007;213:286-300 PMCID:PMC2701258

[12]

Timchenko NA.Aging and liver regeneration..Trends Endocrinol Metab2009;20:171-6

[13]

Taki-Eldin A,Xie HY.Liver regeneration after liver transplantation..Eur Surg Res2012;48:139-53

[14]

Fried LP,Walston J,Hirsch C.Frailty in older adults: evidence for a phenotype..J Gerontol A Biol Sci Med Sci2001;56:M146-56

[15]

Rockwood K,MacKnight C,Bergman H.Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging..J Gerontol A Biol Sci Med Sci2004;59:1310-7

[16]

Chen X,Leng SX.Frailty syndrome: an overview..Clin Interv Aging2014;9:433-41 PMCID:PMC3964027

[17]

Robinson TN,Brummel NE,Brown CH.Frailty for surgeons: review of a national institute on aging conference on frailty for specialists..J Am Coll Surg2015;221:1083-92 PMCID:PMC4673051

[18]

Richards SJG,Geddes JA,Hampton MB.Frailty in surgical patients..Int J Colorectal Dis2018;33:1657-66

[19]

Feinstein AR.The pre-therapeutic classification of co-morbidity in chronic disease..J Chronic Dis1970;23:455-68

[20]

Francis L.Perspectives on the Meaning of “Disability”..AMA J Ethics2016;18:1025-33

[21]

Beggs T,Szwajcer A,Arora RC.Frailty and perioperative outcomes: a narrative review..Can J Anaesth2015;62:143-57

[22]

Fulop T,Witkowski JM,Loeb M.Aging, frailty and age-related diseases..Biogerontology2010;11:547-63

[23]

Clegg A,Iliffe S,Rockwood K.Frailty in elderly people..Lancet2013;381:752-62 PMCID:PMC4098658

[24]

Walston J.Frailty--the search for underlying causes..Sci Aging Knowledge Environ2004;2004:pe4

[25]

Ko FC.Preoperative frailty evaluation: a promising risk-stratification tool in older adults undergoing general surgery..Clin Ther2019;41:387-99 PMCID:PMC6585449

[26]

Fong Y,Fortner JG,Turnbull AD.Liver resection for colorectal metastases..J Clin Oncol1997;15:938-46

[27]

Ferrero A,Polastri R,Tesoriere R Lo.Hepatectomy as treatment of choice for hepatocellular carcinoma in elderly cirrhotic patients..World J Surg2005;29:1101-5

[28]

Ijtsma AJC,van der Hilst CS,de Jong KP.The survival paradox of elderly patients after major liver resections..J Gastrointest Surg2008;12:2196

[29]

Adam R,Elias D,Ramos E.Liver resection of colorectal metastases in elderly patients..Br J Surg2010;97:366-76

[30]

Sulpice L,Campillo B,Guillaud A.Advanced age remains an achilles heel for liver resections..World J Surg2014;38:918-26

[31]

Reddy SK,Turley RS,Geller DA.Major liver resection in elderly patients: a multi-institutional analysis..J Am Coll Surg2011;212:787-95

[32]

Ziogas IA.Evolving role of Sorafenib in the management of hepatocellular carcinoma..World J Clin Oncol2017;8:203-13 PMCID:PMC5465010

[33]

Brunot A,Pracht M.Hepatocellular carcinoma in elderly patients: challenges and solutions..J Hepatocell Carcinoma2016;3:9-18 PMCID:PMC4994800

[34]

Ziogas IA.Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma..World J Gastrointest Surg2017;9:233-45 PMCID:PMC5752958

[35]

Giovanardi F,Bertacco A.Resection for hepatocellular cancer: overpassing old barriers..Transl Gastroenterol Hepatol2018;3:64 PMCID:PMC6182022

[36]

Kondo K,Funagayama M,Otani K.Hepatic resection is justified for elderly patients with hepatocellular carcinoma..World J Surg2008;32:2223-9

[37]

Hamaoka M,Ishiyama K,Tahara H.Evaluation of the risk factors and prognostic factors of hepatectomy for hepatocellular carcinoma in patients aged 80 years or more..J Hepatobiliary Pancreat Sci2017;24:58-64

[38]

Portolani N,Coniglio A,Prestini K.Limited liver resection: a good indication for the treatment of hepatocellular carcinoma in elderly patients..Jpn J Clin Oncol2011;41:1358-65

[39]

Mizuguchi T,Meguro M,Ota S.Impact of aging on morbidity and mortality after liver resection: a systematic review and meta-analysis..Surg Today2015;45:259-70

[40]

Phan K,Ha H,Lam V.Hepatic resection for malignant liver tumours in the elderly: a systematic review and meta-analysis..ANZ J Surg2015;85:815-22

[41]

Dent E,Hoogendijk EO.Frailty measurement in research and clinical practice: a review..Eur J Intern Med2016;31:3-10

[42]

Makary MA,Pronovost PJ,Bandeen-Roche K.Frailty as a predictor of surgical outcomes in older patients..J Am Coll Surg2010;210:901-8

[43]

Chow WB,Merkow RP,Esnaola NF.Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society..J Am Coll Surg2012;215:453-66

[44]

Hubbard R.Australian and New Zealand Society for Geriatric Medicine: position statement - frailty in older people..Australas J Ageing2015;34:68-73

[45]

Rockwood K.Frailty in relation to the accumulation of deficits..J Gerontol A Biol Sci Med Sci2007;62:722-7

[46]

Rockwood K,McDowell I.Factors associated with institutionalization of older people in Canada: testing a multifactorial definition of frailty..J Am Geriatr Soc1996;44:578-82

[47]

Subramaniam S,Soriano RP.New 5-factor modified frailty index using American College of Surgeons NSQIP Data..J Am Coll Surg2018;226:173-81.e8

[48]

Louwers L,Rubinfeld I.Use of a simplified frailty index to predict Clavien 4 complications and mortality after hepatectomy: analysis of the National Surgical Quality Improvement Project database..Am J Surg2016;211:1071-6

[49]

Gani F,Amini N,Margonis GA.Frailty as a risk predictor of morbidity and mortality following liver surgery..J Gastrointest Surg2017;21:822-30

[50]

Welsh TJ,Gladman JR.Comprehensive geriatric assessment--a guide for the non-specialist..Int J Clin Pract2014;68:290-3 PMCID:PMC4282277

[51]

Feng MA,Crowell K,Nielsen ME.Geriatric assessment in surgical oncology: a systematic review..J Surg Res2015;193:265-72 PMCID:PMC4267910

[52]

Decoster L,Mohile S,Basso U.Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: An update on SIOG recommendations..Ann Oncol2015;26:288-300

[53]

Kaibori M,Matsui K,Inoue K.Geriatric assessment as a predictor of postoperative complications in elderly patients with hepatocellular carcinoma..Langenbeck’s Arch Surg2016;401:205-14

[54]

Overcash JA,Extermann M.The abbreviated comprehensive geriatric assessment (aCGA): a retrospective analysis..Crit Rev Oncol Hematol2005;54:129-36

[55]

Overcash JA,Moody L,Cobb S.The abbreviated comprehensive geriatric assessment (aCGA) for use in the older cancer patient as a prescreen: scoring and interpretation..Crit Rev Oncol Hematol2006;59:205-10

[56]

Morley JE,Miller DK.A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans..J Nutr Health Aging2012;16:601-8 PMCID:PMC4515112

[57]

Woo J,Wong M,Wong M.Frailty screening in the community using the FRAIL scale..J Am Med Dir Assoc2015;16:412-9

[58]

Rolfson DB,Tsuyuki RT,Rockwood K.Validity and reliability of the Edmonton Frail Scale..Age Ageing2006;35:526-9 PMCID:PMC5955195

[59]

Perna S,Bologna C,Riva A.Performance of edmonton frail scale on frailty assessment: its association with multi-dimensional geriatric conditions assessed with specific screening tools..BMC Geriatr2017;17:2 PMCID:PMC5209899

[60]

Meyers BM,Rask S,Phillips CM.Utility of the edmonton frail scale in identifying frail elderly patients during treatment of colorectal cancer..J Gastrointest Oncol2017;8:32-8 PMCID:PMC5334059

[61]

Partridge JSL,Dhesi JK.Frailty in the older surgical patient: a review..Age Ageing2012;41:142-7

[62]

Rockwood K,MacKnight C,Hogan DB.A global clinical measure of fitness and frailty in elderly people..CMAJ2005;173:489-95 PMCID:PMC1188185

[63]

Juma S,Montero-Odasso M.Clinical frailty scale in an acute medicine unit: a simple tool that predicts length of stay..Can Geriatr J2016;19:34-9 PMCID:PMC4922366

[64]

Tanaka S,Iida H,Nomi T.Preoperative assessment of frailty predicts age-related events after hepatic resection: a prospective multicenter study..J Hepatobiliary Pancreat Sci2018;25:377-87

[65]

Satake S,Hong YJ,Endo H.Validity of the kihon checklist for assessing frailty status..Geriatr Gerontol Int2016;16:709-15

[66]

García-Peña C,Gutiérrez-Robledo LM,Arango-Lopera VE.Handgrip strength predicts functional decline at discharge in hospitalized male elderly: a hospital cohort study..PLoS One2013;8:e69849 PMCID:PMC3723742

[67]

Podsiadlo D.The timed “Up & Go”: a test of basic functional mobility for frail elderly persons..J Am Geriatr Soc1991;39:142-8

[68]

Huisman MG,Ugolini G,Spiliotis J.“Timed Up & Go”: a screening tool for predicting 30-day morbidity in onco-geriatric surgical patients? A multicenter cohort study..PLoS One2014;9:e86863 PMCID:PMC3901725

[69]

Chen SY,Cerullo M,Safar B.The effect of frailty index on early outcomes after combined colorectal and liver resections..J Gastrointest Surg2018;22:640-9

[70]

Itoh S,Sakata K,Mano Y.Slow gait speed is a risk factor for complications after hepatic resection..J Gastrointest Surg2019;23:1810-6

[71]

Okabe H,Higashi T,Ikuta Y.Frailty predicts severe postoperative complication after elective hepatic resection..Gastrointest Tumors2019;6:28-35 PMCID:PMC6738158

[72]

Hozo SP,Hozo I.Estimating the mean and variance from the median, range, and the size of a sample..BMC Med Res Methodol2005;5:13 PMCID:PMC1097734

PDF

182

Accesses

0

Citation

Detail

Sections
Recommended

/