The role of small extracellular vesicles in post-traumatic stress disorder

Abstract

Post-Traumatic Stress Disorder (PTSD) represents a significant mental health challenge closely associated with the consequences of traumatic experiences. Recently, small extracellular vesicles (sEVs) have been recognized as vital elements in the facilitation of intercellular communication. This review delves into the potential roles and mechanisms of sEVs in PTSD, concentrating on their involvement in neural signaling, immune system reactions, and the modulation of molecular biomarkers related to psychological disorders. By integrating recent research outcomes, this article aims to provide fresh insights into the pathophysiological aspects of PTSD and investigate prospective therapeutic approaches, underlining the significance of sEVs within the broader context of stress-related conditions.

Keywords

Small extracellular vesicles / Post-traumatic stress disorder / Molecular biomarkers

CRediT authorship contribution statement

Haixin Zhang: Writing-review & editing, Writing - original draft. Qile Zhang: Writing-original draft. Shicheng Li: Writing-original draft. Fanzhen Kong: Writing-review & editing, Writing - original draft, Supervision, Project administration, Conceptualization.

Consent for publication

All the authors have approved the manuscript and have provided consent for its submission to your esteemed journal.

Ethics approval and consent to participate

Not applicable.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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