The genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL)

Abstract

Background The genic etiology of sudden sensorineural hearing loss (SSNHL) is associated with gene polymorphism which is related to oxygen metabolism of cochlear hair cells.

Objective To investigate the genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL).

Method The genotype of three tag SNPs (rs5746136, rs2842960, rs4880) variants were detected among 148 patients with SSNHL in Yunnan Province, China, and 171 matched participants without hearing loss in control group were used to screen for any risk-associated SNPs.

Result The A/G genotype at rs5746136 locus (OR=1.811, 95 % CI=1.161-2.826, p = 0.009) was associated with susceptibility to SSNHL in Yunnan Province.

Conclusion SOD2 gene with the rs5746136 A/G genotype is associated with an increased risk of sudden sensorineural hearing loss (SSNHL), whereas the other two tag SNPs, rs2842960 and rs4880, show no significant correlation with SSNHL. Specifically, the tag SNP rs5746136 A/G appears to be a susceptibility gene for SSNHL.

Keywords

Sudden sensorineural hearing loss (SSNHL) / SOD2 / Single nucleotide polymorphism

Compliance with ethical standards

Our experiments comply with ethical standards. All the subjects included in the patient group and the control group signed the informed consent form.

The author contribution statement

DJH, and ZJQ designed the study. MGF and CXB collected the data. CYL and HL sorted out the data. DJH and ZJQ analyzed the data, drew pictures and made tables. DJH drafted the manuscript. DJH and ZJQ contributed to the interpretation of the results and critical revision of the manuscript for important intellectual content and approved the final version of the manuscript. All authors have read and approved the final manuscript.

Funding

This work was supported by grants from the National Natural Science Foundation of China (No. 82360224), the Open Project of Yunnan Provincial Key Laboratory of Clinical Virology (202205AG070053), the Key Basic Research Program of Yunnan Province (No. 202201AS070065), and Kunming University of Science and Technology Medical Joint Project (KUST-KH2022038Y). The study sponsors had no involvement in the work. The study sponsors had no involvement in the work.

Data availability

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Declaration of Competing Interest

The author declare that they have no conflict interest.

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