Circadian rhythm, epigenetics and disease interaction

Abstract

Identifying the circadian clock first provided the genetic basis for behaviour, and our understanding of circadian rhythms has since expanded to provide molecular insight into disease and physiology. The synchronization of central and peripheral clocks and robust daily rhythms can be achieved in a wide range of physiological systems and homeostatic responses can be supplemented. The rhythmical epigenome, which works as a central regulator, determines the circadian transcription of cell types. The rhythmical epigenome imposes oscillation on biological systems that momentarily split metabolism within 24 h. Interactions between the endogenous circadian system govern blood pressure, sleep, obesity and postural variations. Human health is dependent on the circadian rhythm. It can depict disease dynamics as well as overall drug efficacy monitoring to optimize the therapy effect. Circadian rhythms can collectively drive various metabolic activities, but dietary habits, sleep patterns, and other factors can also influence the circadian rhythm. The synergy of circadian rhythm and metabolism can bring new insights and personalized analysis for disease development causes and prevention. The understanding of the molecular clock and disease relationship can be exploited to determine treatment timing as well as new therapy targets.

Keywords

Circadian rhythm / CLOCK / BMAL1 / Diseases

Authors' contributions

RK, MO designed research; RK analyzed data; RK, MO wrote the paper.

Data Availability

All used materials are commercially available. This article as no datasets were generated or analyzed during the current study.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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