PDHE1α in DNA damage repair: a critical chromatin acetylation regulator

Bingsong Huang; Yuping Chen; Jian Yuan

doi:10.1007/s42764-023-00112-6

Genome Instability & Disease ›› 2023, Vol. 4 ›› Issue (6) : 349-350. DOI: 10.1007/s42764-023-00112-6

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PDHE1α in DNA damage repair: a critical chromatin acetylation regulator

Bingsong Huang¹^,² ,
Yuping Chen¹ ,
Jian Yuan¹^,^c

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Abstract

A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand breaks, crucial for chromatin remodeling and DNA repair. PDHE1α recruitment depends on PARP1 and impacts genome stability and cancer therapy resistance. This research sheds light on DNA damage response and chromatin acetylation regulation.

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Bingsong Huang, Yuping Chen, Jian Yuan. PDHE1α in DNA damage repair: a critical chromatin acetylation regulator. Genome Instability & Disease, 2023, 4(6): 349‒350 https://doi.org/10.1007/s42764-023-00112-6