Are Probiotics a Panacea for All Diseases? A Scientific Opinion

Catarina Rodrigues Gomes , Vasco Azevedo

Food Res. Suppl. ›› 2026, Vol. 1 ›› Issue (1) : 10002

PDF (684KB)
Food Res. Suppl. ›› 2026, Vol. 1 ›› Issue (1) :10002 DOI: 10.70322/frs.2025.10002
Opinion
research-article
Are Probiotics a Panacea for All Diseases? A Scientific Opinion
Author information +
History +
PDF (684KB)

Abstract

Probiotics have gained widespread attention for their potential health benefits, particularly in promoting gut health and modulating the immune system. This article critically examines whether probiotics can be a universal remedy for all diseases, as often claimed in scientific literature and popular media. The objective is to evaluate the current scientific evidence regarding the efficacy of probiotics in preventing and treating various medical conditions, including gastrointestinal disorders, metabolic syndromes, allergies, and mental health issues. While some studies suggest promising outcomes in specific contexts, the evidence remains inconsistent and often limited to specific strains and conditions. Importantly, this review highlights that probiotics are not a one-size-fits-all solution and their effects can vary widely depending on individual physiology, dosage, and microbial composition. The article also addresses safety concerns, regulatory challenges, and the need for more rigorous, large-scale clinical trials. By analyzing existing data and expert opinions, this work aims to separate fact from hype and provide a balanced perspective on probiotics’ true potential and limitations in modern medicine.

Keywords

Probiotics / Gut health / Immune system / Microbiome / Clinical evidence / Health claims

Cite this article

Download citation ▾
Catarina Rodrigues Gomes, Vasco Azevedo. Are Probiotics a Panacea for All Diseases? A Scientific Opinion. Food Res. Suppl., 2026, 1(1): 10002 DOI:10.70322/frs.2025.10002

登录浏览全文

4963

注册一个新账户 忘记密码

Acknowledgments

We would like to thank CNPq for paying me a scientific productivity grant and for financing our work with probiotics with other agencies, such as FAPEMIG and CAPES.

Author Contributions

Conceptualization, C.R.G. and V.A.; Investigation, V.A.; Data Curation, C.R.G. and V.A.; Writing—Original Draft Preparation, V.A.; Writing—Review & Editing, C.R.G. and V.A.; Visualization, C.R.G.; Supervision, V.A.

Ethics Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data supporting this opinion piece are available within the article, its references or upon request.

Funding

No direct funding to make this manuscript.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

[1]

Goodman C, Keating G, Georgousopoulou E, Hespe C, Levett K, Tang MLK. Probiotics for the prevention of antibiotic-associated diarrhea: A systematic review and meta-analysis. BMJ Open 2021, 11, e043054. doi:10.1136/bmjopen-2020-043054.

[2]

Zeng Q, Li P, Wu H, Zhuang Y, Zhang Y, Asemani S, et al. Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy. Eur. J. Med. Res. 2025, 30, 515. doi:10.1186/s40001-025-02788-w.

[3]

Ford AC, Moayyedi P, Chey WD, Harris LA, Lacy BE, Saito YA, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome. Am. J. Gastroenterol. 2021, 116, 17-31. doi:10.1038/s41395-018-0084-x.

[4]

Chappell KD, Olayinka L, Sutton R, Seow C, Debruyn J, van Zanten S, et al. A framework for clinical care pathway renewal: An example from inflammatory bowel disease. BMC Med. Res. Methodol. 2025, 25, 173. doi:10.1186/s12874-025-02616-z.

[5]

King S, Glanville J, Sanders ME, Fitzgerald A, Dicksved J. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: Systematic review and meta-analysis. Br. J. Nutr. 2021, 125, 523-534. doi:10.3390/nu16091352.

[6]

Mosquera FEC, Lizcano Martinez S, Liscano Y. Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials. Nutrients 2024, 16, 1352. doi:10.3390/nu16091352.

[7]

Goldenberg JZ, Yap C, Lytvyn L, Lo CKF, Beardsley J, Mertz D, et al. Probiotics for the prevention of Clostridioides difficile-associated diarrhoea in adults and children. Cochrane Database Syst. Rev. 2023, 4, CD006095. doi:10.1002/14651858.CD006095.pub5.

[8]

Huang R, Xing HY, Liu HJ, Chen ZF, Tang BB. Efficacy of probiotics in the treatment of acute diarrhea in children: A systematic review and meta-analysis of clinical trials. Transl. Pediatr. 2021, 10, 3248-3260. doi:10.21037/tp-21-511.

[9]

Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 2013, 110, 9066-9071. doi:10.1073/pnas.1219451110.

[10]

Cocean A-M, Vodnar DC. Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2024, 134, 111073. doi:10.1016/j.pnpbp.2024.111073.

[11]

Slykerman RF, Davies N, Donohoe R. Evaluating the scientific evidence to support mental health and well-being claims made on probiotic products. Nutr. Health 2025. doi:10.1177/02601060241305682.

[12]

Zawistowska-Rojek A, Zaręba T, Tyski S. Microbiological Testing of Probiotic Preparations. Int. J. Environ. Res. Public. Health 2022, 19, 5701. doi:10.3390/ijerph19095701.

[13]

Vijayaganapathi A, Mohanasrinivasan V. A Review of Next-Generation Probiotics—As a Gateway to Biotherapeutics. Probiotics Antimicrob. Prot. 2025. doi:10.1007/s12602-025-10606-2.

[14]

Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nat. Rev. Gastroenterol. Hepatol. 2019, 16, 35-56. doi:10.1038/s41575-018-0061-2.

[15]

Khoruts A, Hoffmann D, Britton RA. Probiotics: Promise, Evidence, and Hope. Gastroenterology 2020, 159, 409-413. doi:10.1053/j.gastro.2020.05.058.

[16]

Ruszkowski J, Majkutewicz K, Rybka E, Kutek M, Dębska-Ślizień A, Witkowski JM. The methodological quality and clinical applicability of meta-analyses on probiotics in 2020: A cross-sectional study. Biomed. Pharmacother. 2021, 142, 112044. doi:10.1016/j.biopha.2021.112044.

[17]

Falzone L, Lavoro A, Candido S, Salmeri M, Zanghì A, Libra M. Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain. Gut Microbes 2024, 16, 2397874. doi:10.1080/19490976.2024.2397874.

[18]

Ng KM, Aranda-Díaz A, Tropini C, Frankel MR, Van Treuren W, O’Loughlin CT, et al. Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs. Cell Host Microbe 2019, 26, 650-665.e4; Erratum in Cell Host Microbe 2020, 28, 628. doi:10.1016/j.chom.2020.09.001.

[19]

Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: Systematic review and meta-analysis. BMJ 2010, 340, c2609. doi:10.1136/gut.2008.167270.

PDF (684KB)

0

Accesses

0

Citation

Detail

Sections
Recommended

/