Electrospun multifunctional tissue engineering scaffolds

Abstract

Tissue engineering holds great promises in providing successful treatments of human body tissue loss that current methods are unable to treat or unable to achieve satisfactory clinical outcomes. In scaffold-based tissue engineering, a high-performance scaffold underpins the success of a tissue engineering strategy and a major direction in the field is to create multifunctional tissue engineering scaffolds for enhanced biological performance and for regenerating complex body tissues. Electrospinning can produce nanofibrous scaffolds that are highly desirable for tissue engineering. The enormous interest in electrospinning and electrospun fibrous structures by the science, engineering and medical communities has led to various developments of the electrospinning technology and wide investigations of electrospun products in many industries, including biomedical engineering, over the past two decades. It is now possible to create novel, multicomponent tissue engineering scaffolds with multiple functions. This article provides a concise review of recent advances in the R & D of electrospun multifunctional tissue engineering scaffolds. It also presents our philosophy and research in the designing and fabrication of electrospun multicomponent scaffolds with multiple functions.

Key words： electrospinning; monocomponent; multicomponent; scaffold; core--shell; drug; biomolecule; growth factor; controlled release

Acknowledgements

This work was supported by the Hong Kong Research Grants Council through GRF grants (HKU 7181/09E and HKU 7177/13E). The authors thank an anonymous donor for generously providing financial support for our group’s research in biomaterials and tissue engineering at The University of Hong Kong.

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