Structural biology of the macroautophagy machinery

Abstract

Macroautophagy is a conserved degradative process mediated through formation of a unique double-membrane structure, the autophagosome. The discovery of autophagy-related (Atg) genes required for autophagosome formation has led to the characterization of approximately 20 genes mediating this process. Recent structural studies of the Atg proteins have provided the molecular basis for their function. Here we summarize the recent progress in elucidating the structural basis for autophagosome formation.

Keywords

macroautophagy / autophagy / Atg proteins / structural biology / X-ray crystallography / single-particle electron microscopy

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