Membrane-bound O-acyltransferases (MBOAT)

Abstract

The MBOAT enzyme family, identified in 2000, comprises 11 genes in the human genome that participate in a variety of biological processes. MBOAT enzymes contain multiple transmembrane domains and share two active site residues, histidine and asparagine. Several MBOAT members are drug targets for major human diseases, including atherosclerosis, obesity, Alzheimer disease, and viral infections. Here we review the historical aspects of MBOAT enzymes, classify them biochemically into 3 subgroups, and describe the essential features of each member.

Keywords

cholesterol metabolism / neutral lipid biosynthesis / protein acylation / membrane phospholipid remodeling / atherosclerosis / diabetes / obesity / cancer / nutrient sensing

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Acknowledgments

We thank Dr. Ellen Chang and the reviewer for careful reading of the manuscript. The research in our laboratory is supported by US NIH grants HL60306 and AG37609. Due to a lack of space, we were not able to cover the relevant literature comprehensively.

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg