PHLPP phosphatase: a key mediator integrating multiple signaling pathways

Hui ZHONG

Front. Biol. ›› 2010, Vol. 5 ›› Issue (3) : 193 -194.

PDF (55KB)
Front. Biol. ›› 2010, Vol. 5 ›› Issue (3) : 193 -194. DOI: 10.1007/s11515-010-0041-6
HIGHLIGHT
HIGHLIGHT

PHLPP phosphatase: a key mediator integrating multiple signaling pathways

Author information +
History +
PDF (55KB)

Cite this article

Download citation ▾
Hui ZHONG. PHLPP phosphatase: a key mediator integrating multiple signaling pathways. Front. Biol., 2010, 5(3): 193-194 DOI:10.1007/s11515-010-0041-6

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Brognard J, Newton A C (2008). PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab, 19(6): 223-230

[2]

Claudio E, Brown K, Park S, Wang H, Siebenlist U (2002). BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat Immunol, 3(10): 958-965

[3]

Coope H J, Atkinson P G P, Huhse B, Belich M, Janzen J, Holman M J, Klaus G G B, Johnston L H, Ley S C (2002). CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J, 21(20): 5375-5385

[4]

Dejardin E, Droin N M, Delhase M, Haas E, Cao Y, Makris C, Li Z W, Karin M, Ware C F, Green D R (2002). The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity, 17(4): 525-535

[5]

Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z (2000). The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity, 12(4): 419-429

[6]

Eliopoulos A G, Caamano J H, Flavell J, Reynolds G M, Murray P G, Poyet J L, Young L S (2003). Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. Oncogene, 22(48): 7557-7569

[7]

Karin M, Ben-Neriah Y (2000). Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol, 18: 621-663

[8]

Karin M, Hunter T (1995). Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol, 5(7): 747-757

[9]

Senftleben U, Cao Y, Xiao G, Greten F R, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S C, Karin M (2001). Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science, 293(5534): 1495-1499

[10]

Xiao G, Fong A, Sun S C (2004). Induction of p100 processing by NF-kB-inducing kinase involves docking IkB kinase a (IKKa) to p100 and IKKamediated phosphorylation. J Biol Chem, 279: 30099-30105

[11]

Xiao G, Harhaj E W, Sun S C (2001). NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell, 7(2): 401-409

[12]

Yamaoka S, Courtois G, Bessia C, Whiteside S T, Weil R, Agou F, Kirk H E, Kay R J, Israël A (1998). Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell, 93(7): 1231-1240

[13]

Zandi E, Rothwarf D M, Delhase M, Hayakawa M, Karin M (1997). The IkB kinase complex (IKK) contains two kinase subunits, IKKa and IKKb, necessary for IkB phosphorylation and NF-kB activation. Cell, 91: 243-252

RIGHTS & PERMISSIONS

Higher Education Press and Springer-Verlag Berlin Heidelberg

AI Summary AI Mindmap
PDF (55KB)

773

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/