Antitumor mechanism of Se-containing polysaccharide, a novel organic selenium compound

Abstract

Recent studies on the inhibition of tumor growth by Se-containing polysaccharide were reviewed. Meanwhile, the possible molecular mechanisms of the inhibition of tumor cell growth through antioxidation, induction of tumor cell apoptosis, blockade of cell cycle, and enhancement of immunity by Se-containing polysaccharide were proposed. In the end, the potential application of Se-containing polysaccharide in the prevention and treatment of tumor was elucidated.

Keywords

Se-containing polysaccharide / antitumor / antioxidant / organic selenium / apoptosis

References

[1] Chen C, Zhang Y M, Li Y C, Chu H Y, Xi Y M (2007). In vivo and in vitro anti-tumor response of selenium-protein polysaccharide extracted from rich selenium Agaricus blazei. Food and Agri Immu, 18: 139-149

[2] Chen X C, Lin Z B (1998). Effect of 4-seleno-carrageenan on cyclophosphamide-induced leukopenia in mice. J Beijing Med Univ, 30(4): 317-319 (in Chinese)

[3] Chinnaiyan A M, Orth K, O'Rourke K, Duan H, Poirier G G, Dixit V M (1996). Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem, 271, 4573-4576

[4] Chu H Y, Chen C (2006). Study on apoptosis of K562 cells induced by tumor-bearing herb serum of selenium-protein polysaccharide extracted from Qinba selenium-mushroom. Chin J TCM WM Crit Care, 13(3): 142-145 (in Chinese)

[5] Cohen G M (1997). Caspases: the executioners of apoptosis. Biochem J, 326: 1-16

[6] Cui Q, Shang D J (2004). Anticancer activities of selenium compounds. Chin J Biochem Pharm, 25(4): 247-249 (in Chinese)

[7] Dai W J, Zhong W F, Suo J L, Lin Z B (2001). Inhibitory effects of se-carra on DNA, RNA and protein synthesis of human hepatocarcinoma cells Belp7402 in vitro. J Jining Medical College, 24(1): 18-19 (in Chinese)

[8] Dong Y, Ganther H E, Stewart C, Ip C (2002). Identification of molecular targets associated with selenium-induced growth inhibition in human breast cancer cells using cDNA microarrays. Cancer Res, 62: 708-714

[9] Dong Y, Lee S O, Zhang H, Marshall J, Gao A C, Ip C (2004). Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res, 64: 19-22

[10] Dong Y, Zhang H, Hawthorn L, Ganther H E, Ip C (2003). Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res, 63(1): 52-59

[11] El-Bayoumy K, Sinha R (2005). Molecular chemoprevention by selenium: a genomic approach. Mutat Res Fundam Mol Mech Mutagen, 591(1,2): 224-236

[12] Fuentes-Prior P, Salvesen G S (2004). The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J, 384: 201-232

[13] Gong X Z (1996). Investigation on selenoastragalan. J Shenzhen Univ, 13(3,4): 68-75 (in Chinese)

[14] He G, Cheng C, Lu R (1997). Studies on biological effects of Kappa-selenocarrageenan on human breast cancer cell line BCaP-37. Chin J Prev Med, 31(2): 103-106 (in Chinese)

[15] Hu H, Jiang C, Schuster T, Li G X, Daniel P T, Lu J (2006). Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther, 5: 1873-1882

[16] Irani K, Xia Y, Zweier J L, Sollott S J, Der C J, Fearon E R, Sundaresan M, Finkel T, Goldschmidt-Clermont P J (1997). Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science, 275(5306): 1649-1652

[17] Jiang Q, Zhang W M, Yang C X (1997). Study of selenium as an adimant in chemotherapy of cancer. Cancer Res Prev Treat, 24(2): 110-111 (in Chinese)

[18] Liu S L, Shi D Y, Pan X H, Fu X Y (1998). Study on effects of se on apoptosis of hepatoma cell. Acta Biophysica Sinica, 14(3): 553-557 (in Chinese)

[19] Liu S L, Shia D Y, Liu G Z, Chen H L, Liu S J, Hu Y D (2000). Roles of Se and NO in apoptosis of hepatoma cells. Life Sci, 68: 603-610

[20] Martin S J, Green D R (1995). Protease activation during apoptosis: death by a thousand cuts. Cell (Cambridge), 82(3): 349-352

[21] Saito Y, Yoshida Y, Akazawa T, Takahashi K, Niki E (2003). Cell death caused by selenium deficiency and protective effect of antioxidants. J Bio Chem, 287(41): 39428-394341

[22] Serafin Munoz A H, Kubachka K, Wrobel K, Gutierrez Corona J F, Yathavakill S K V, Caruso J A, Wrobel K (2006). Se-enriched mycelia of pleurotus ostreatus: distribution of selenium in cell walls and cell membranes/cytoso. J Agric Food Chem, 54: 3440-3444

[23] Shang D J, Wang X M, Xu Y T, Tian X, An Y (2002). Separation, purification and analysis of selenium activity structure of SeGLP-1. Acta Edulis Fungi, 9(1): 22-27 (in Chinese)

[24] Slee E A, Harte M T, Kluck R M, Wolf B B, Casiano C A, Newmeyer D D, Wang H G, Reed J C, Nicholson D W, Alnemri E S, Green D R, Martin S J (1999). Ordering the cytochrome C initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and-10 in a caspase-9 dependent manner. J Cell Bio, 144(2): 281-292

[25] Wei H L, Zhang Z W, Gao L P, Li L J, Yi J, Sun J (2006). Kappa-selenocarrageenan overcomes apoptosis resistance in multidrug-resistant K562/ADM cells by down-regulating expression of mdr1 gene and its product P-glycoprotein. Modern Oncol, 14(12): 1489-1492 (in Chinese)

[26] Wu X (2004). Experimental studies on induction of apoptosis and inhibition of metastasis of human osteosarcoma cells by kappa-selenocarrageenan. Shanghai: Fudan University Press, 28-96 (in Chinese)

[27] Xu B H (1999). Report on phase I and II clinical trials of k-selenocarrageenan. Beijing: Chinese Academy of Medical Sciences and Peking Union Medical College Press, 6-82 (in Chinese)

[28] Yang D W (2007). Studies on polysaccdharide containing selenium of cardamine with rich selenium from enshi. Hunan: Agricultural University Press, 106-114 (in Chinese)

[29] Zhang Z W, Wei H L, Su H (2005a). Immunomodulatory and anti-tumor effects of Kappa-selenocarrageenan. J Lanzhou Univ (Medical Sciences), 31(2): 88-91 (in Chinese)

[30] Zhang Z W, Wei H L, Su H X, Liu J M, Hao C Y (2005b). Kappa-selenocarrageenan induced apoptosis of multidrug-resistant human leukemia cell and its mechanism. Chin J Clin Pharmacol Ther, 10(5): 505-508 (in Chinese)

[31] Zhao L, Zhao G H, Du M, Zhao Z D, Xiao L X, Hu X S (2008). Effect of selenium on increasing free radical scavenging activities of polysaccharide extracts from a Se-enriched mushroom species of the genus Ganoderma. Eur Food Res Technol, 226: 499-505

[32] Zhao R, Yu B M, Zheng M H, Li D H, Zhang G C, Dong C Q, Zou H Z (2001). Effect of selenium on the expression of Fas/FasL in T lymphocyte anti colonic cancer cells. Chin J Surg, 18(1): 21-22 (in Chinese)

Acknowledgements

The study was supported by the National Natural Science Foundation of China (Grant No. 30770276).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg