Frontiers of Agriculture in China >

2009 , Vol. 3 >Issue 4: 478 - 485

DOI: https://doi.org/10.1007/s11703-009-0073-3

Research articles

Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells

Expand
  • 1.Department of Basic Veterinary Medicine, College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China; 2.Department of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066064, China;

Published date: 05 Dec 2009

Fold

Abstract

The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and reviewe some strategies that recently develop for enhancing DNA vaccine potency.

Key words： DNA vaccine; antigen presenting cells; targeting; immune response

Cite this article

Xingxing WANG, Fei ZHONG, Nan LI, Dongmei HAN, Sumin PAN, Xiujin LI, . Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells[J]. Frontiers of Agriculture in China, 2009 , 3(4) : 478 -485 . DOI: 10.1007/s11703-009-0073-3

Options
Outlines

/

〈 〉