Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells

Xingxing WANG1,Fei ZHONG1,Nan LI1,Dongmei HAN1,Sumin PAN1,Xiujin LI2,

Front. Agric. China ›› 2009, Vol. 3 ›› Issue (4) : 478-485.

PDF(122 KB)
PDF(122 KB)
Front. Agric. China ›› 2009, Vol. 3 ›› Issue (4) : 478-485. DOI: 10.1007/s11703-009-0073-3
Research articles
Research articles

Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells

  • Xingxing WANG1,Fei ZHONG1,Nan LI1,Dongmei HAN1,Sumin PAN1,Xiujin LI2,
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Abstract

The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and reviewe some strategies that recently develop for enhancing DNA vaccine potency.

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DNA vaccine / antigen presenting cells / targeting / immune response

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Xingxing WANG, Fei ZHONG, Nan LI, Dongmei HAN, Sumin PAN, Xiujin LI,. Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells. Front. Agric. China, 2009, 3(4): 478‒485 https://doi.org/10.1007/s11703-009-0073-3
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