Objective: To analyze the efficacy of the AngioJet thrombus aspiration system combined with catheter-directed thrombolysis (CDT) in treating acute deep venous thrombosis (ADVT).

Methods: Thirty patients with ADVT admitted to a tertiary A-grade hospital from January 2020 to March 2021 were randomly assigned to either the CDT group or the AngioJet group, with 15 patients in each group. The CDT group underwent catheter-directed thrombolysis, while the AngioJet group received the treatment with the AngioJet thrombus aspiration system. There were no statistically significant differences between the two groups in terms of gender, age, onset time, or thrombus type (p > .05). Thrombus clearance rates, limb edema resolution rates, total urokinase dosage, thrombolysis duration, and complications were compared between the two groups of patients with ADVT in this study.

Results: The AngioJet group demonstrated superior thrombectomy grading in comparison to the CDT group (Z = 2.340, p = .019). The limb edema resolution rate was significantly higher in the AngioJet group (93.33%) than that in the CDT group (53.33%) (p < .05). The thrombolysis duration in the AngioJet group (0.50 ± 0.11 h) was significantly shorter than that in the CDT group (72.14 ± 0.42 h) (p < .05). The urokinase dosage in the AngioJet group (18.51 ± 2.02 × 10⁴ U) was significantly lower than that in the CDT group (85.34 ± 2.75 × 10⁴ U) (p < .05). The incidence of complications in the AngioJet group (13.33%) was lower than that in the CDT group (26.67%), with no statistically significant difference (p > .05).

Conclusions: The AngioJet thrombus aspiration system demonstrates superior thrombus clearance efficacy in comparison to CDT in ADVT patients, with shorter thrombolysis duration, reduced urokinase dosage, and favorable clinical safety.

Kawasaki disease (KD) is an acute vasculitis that commonly presents with prolonged fever and mucocutaneous involvement. The development of opportunistic infections, such as oral thrush, during immunosuppressive therapy remains a clinical challenge. This report highlights the management of recurrent fever complicated by oral thrush in a pediatric KD case. A 1-year-old girl with KD developed recurrent fever and oral thrush during prednisone tapering (2 mg/kg/day). Metagenomic NGS ruled out bacterial/viral infections, confirming IVIG-resistant KD. She achieved remission following antifungal therapy with nystatin, methylprednisolone (2 mg/kg/day), and high-dose aspirin (100 mg/kg/day), with resolution of fever and thrush by hospital day 13. This case highlights the need for prompt antifungal intervention while maintaining immunosuppression to achieve disease control. These findings are still preliminary and based on a single case.