Efficacy of cyclosporin eye drops in the treatment of dry eye after cataract surgery

Abstract

Objective: To explore the value of cyclosporin eye drops in treating dry eye after cataract surgery.

Methods: A total of 150 patients with dry eye after cataract surgery were randomly divided into group A (n = 50), group B (n = 50), and group C (n = 50). Artificial tears combined with cyclosporin eye drops were used in group A, artificial tears were used in group B, and no dry eye medication was used in group C. The clinical efficacy, ocular surface function and tear inflammatory factor level before and after surgery were compared between the groups.

Results: The total effective rate of group A was 96.00%, which was significantly higher than that of group B and group C (p <.05); three months after surgery, the levels of corneal fluorescein staining score (FL score), tear meniscus height (TMH) and tear inflammatory factors [interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor (TNF-α)] in group A were lower than those in group B, and those indicators in group B were lower than those in group C, and the difference between the two groups was statistically significant (p <.05); three months after surgery, Schirmer test (SIT) and break-up time (BUT) in group A were higher than those in group B, and those indicators in group B were higher than those in group C, and the difference between the two groups was statistically significant (p <.05).

Conclusions: The effect of cyclosporin eye drops in treating dry eye after cataract surgery is satisfactory, significantly improving the ocular surface function and reducing the level of tear inflammatory factors, which is worthy of promotion.

Keywords

Cataract / Dry eyes / Cyclosporin eye drops / Ocular surface function / Inflammatory factors

ACKNOWLEDGEMENTS

Not applicable.

AUTHORS CONTRIBUTIONS

Li Ping contributed to the study conception and review, Feng Ling contributed to data acquisition and manuscript drafting, both authors reviewed and approved the final manuscript.

FUNDING

Not applicable.

CONFLICTS OF INTEREST DISCLOSURE

The authors declare no conflicts of interest.

INFORMED CONSENT

Obtained.

ETHICS APPROVAL

The Publication Ethics Committee of the Sciedu Press. The journal’s policies adhere to the Core Practices established by the Committee on Publication Ethics (COPE).

PROVENANCE AND PEER REVIEW

Not commissioned; externally double-blind peer reviewed.

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

DATA SHARING STATEMENT

No additional data are available.

OPEN ACCESS

This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

COPYRIGHTS

Copyright for this article is retained by the author(s), with first publication rights granted to the journal.

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