This article was designed to forecast the supply and demand of medical postgraduate from 2001 to 2010 and bring forward the development strategy of medical postgraduate education in Hubei province. The line regression, the ratio of health manpower to population, grey dynamics model (1,1) was employed to forecast the supply and demand of medical postgraduate according to the corresponding data from 1991 to 2000 in Hubei province. The results showed that the number of health professionals of Hubei province in 2010 would attain 265892, the graduates’ proportion of which would be about 1.8%; and the demand and supply of medical postgraduate would be 4699 and 2264 respectively. To improve conditions actively to attract and cultivate excellent professionals, especially the senior medical scholars, are effective measures to adjust the degree structure of health manpower as soon as possible in Hubei province.

To evaluate the changes of 3′, 5′-cyclic adenosine monophosphate (cAMP), thromboxane A₂(TXA₂) and prostacyclin (PGI₂) in cerebrospinal fluid (CSF) in the asphyxiated newborn and explore their roles in hypoxic-ischamic brain damage (HIBD). Thirty-six full term newborns were divided into 3 groups, including 12 with moderate-severe hypoxic-ischaemic encephalopathy (HIE), 13 with mild HIE, 11 without HIE (control group). The levels of cAMP, TXB₂ (TXA₂ metabolite) and 6-keto-PGF_1α (PGI₂ metabolite) in CSF and plasma were measured 36–72 h after birth by RIA, and the concentrations were expressed as nM/L (cAMP), ng/L(TXB₂ and 6-keto-PGF_1α). The infants were followed-up at 6 and 12 month of age and Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using Bayley Scales of Infant Development (BSID). The CSF cAMP level in moderate-severe HIE group was 8.60±2.40, significantly lower than that of the mild HIE group (14.83±2.84) and the control group (24.43±2.39) (for bothP<0.01). The levels of TXB₂ and 6-keto-PGF_1α in CFS in the moderate-severe HIE group (206.06±29.74, 168.47±23.02, respectively) were significantly higher than in the mild HIE group (83.37±28.57, 131.42±16.57, respectively,P<0.01) and the control group (41.77±21.58, 86.23±13.05, respectively,P<0.01). The level changes of cAMP, TXB₂ and 6-keto-PGF_1α in plasma in all groups were similar to those in CSF, but no significant difference was found between mild HIE group and the control group (P>0.05). The follow-up results showed that MDI and PDI of the moderate-severe HIE group were the lowest (84.79±13.34, 83.50±13.28, respectively), followed by mild HIE group (102.19±7.02, 99.94±9.08, respectively), with the control group being the highest (116.63±12.08, 116.69±10.87, respectively). Univariate analysis showed some significant difference (the moderate-severe HIE group vs. the mild HIE group or the control group,P<0.01; the mild HIE group vs. the control groupP<0.05). The results suggested that the concentration of cAMP, TXA₂ and T/K ratio in CSF after neonatal asphyxia might be sensitive markers in evaluating the severity of brain damage in early stage and predicting the future outcome.

The expression levels of heat shock protein 70 (HSP70) from peripheral lymphocytes of the patients with allergic rhinitis (AR) and the clinical implication were investigated. In the morning, 3 ml of fasting venous blood was taken out. The lymphocytes were isolated by using Ficoll-Hypaque and the expression of HSP70 in the lymphocytes was detected by using Western blot. In the AR patients the HSP70 level (41.49±15.77 integrated optical density, IOD) were significantly higher than that in the control group (23.89±10.13 IOD,P<0.05). Western blot demonstrated that HSP70 bands in AR patients were more intensive than those in the control group. It was concluded that the elevated HSP70 level in peripheral lymphocytes of the AR patients might contribute to the development of AR.