Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

Abstract

This review provides a concise summary of the origin, biological characteristics, homeostatic maintenance and therapeutic potential of cutaneous MSCs.

The role and potential application value of MSCs in skin pigmentation disorders are discussed.

The significance of single-cell RNA sequencing, CRISPR-Cas9 technology and practical models in MSCs research is highlighted.

Keywords

hair follicle / melanocyte replenishment / melanocyte stem cells / niche / regenerative medicine

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.