Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

Luling Huang; Yuzhi Zuo; Shuli Li; Chunying Li

doi:10.1002/ctm2.1720

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (5) : e1720 DOI: 10.1002/ctm2.1720

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Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

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Abstract

This review provides a concise summary of the origin, biological characteristics, homeostatic maintenance and therapeutic potential of cutaneous MSCs.

The role and potential application value of MSCs in skin pigmentation disorders are discussed.

The significance of single-cell RNA sequencing, CRISPR-Cas9 technology and practical models in MSCs research is highlighted.

Keywords

hair follicle / melanocyte replenishment / melanocyte stem cells / niche / regenerative medicine

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Luling Huang, Yuzhi Zuo, Shuli Li, Chunying Li. Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential. Clinical and Translational Medicine, 2024, 14(5): e1720 DOI:10.1002/ctm2.1720

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.