Integrating single-cell and spatial analysis reveals MUC1-mediated cellular crosstalk in mucinous colorectal adenocarcinoma

Haiyang Zhou; Yiwen Shen; Guangyong Zheng; Beibei Zhang; Anqi Wang; Jing Zhang; Hao Hu; Jiayi Lin; Sanhong Liu; Xin Luan; Weidong Zhang

doi:10.1002/ctm2.1701

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (5) : e1701 DOI: 10.1002/ctm2.1701

RESEARCH ARTICLE

Integrating single-cell and spatial analysis reveals MUC1-mediated cellular crosstalk in mucinous colorectal adenocarcinoma

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Abstract

Tumour microenvironment profiling of MCA is developed

MUC1⁺ tumour cells interplay with FGF7⁺/THBS1⁺ myofibroblasts to promote MCA development.

MS4A4A⁺ macrophages exhibit M2 phenotype in MCA.

ZEB1⁺ endotheliocytes engage in EndMT process in MCA.

Keywords

mucinous colorectal adenocarcinoma / scRNA-seq / spatial transcriptomics / tumour microenvironment

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Haiyang Zhou,Yiwen Shen,Guangyong Zheng,Beibei Zhang,Anqi Wang,Jing Zhang,Hao Hu,Jiayi Lin,Sanhong Liu,Xin Luan,Weidong Zhang. Integrating single-cell and spatial analysis reveals MUC1-mediated cellular crosstalk in mucinous colorectal adenocarcinoma. Clinical and Translational Medicine, 2024, 14(5): e1701 DOI:10.1002/ctm2.1701

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.