Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders

Abstract

An investigation was carried out at the single-cell-level to analyze gut mucosal immune cells alterations in PLWH after ART.

B cells were significantly increased and plasma cells were significantly decreased in the INRs compared to the IRs and NCs.

There are gaps in the transition from gut follicular or memory B cellsinto plasma cells in INRs.

Keywords

B cells / gut / HIV / plasma cells / single-cell RNA sequencing

References

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.