1. SUBMISSION
Authors should kindly note that submission implies that the content has not been published or submitted for publication elsewhere except as a brief abstract in the proceedings of a scientific meeting or symposium.
Once the submission materials have been prepared in accordance with the Author Guidelines, manuscripts should be submitted online at https://mc.manuscriptcentral.com/ctd2.
Click here for more details on how to use ScholarOne.
Data protection:
By submitting a manuscript to or reviewing for this publication, your name, email address, and affiliation, and other contact details the publication might require, will be used for the regular operations of the publication, including, when necessary, sharing with the publisher (Wiley) and partners for production and publication. The publication and the publisher recognize the importance of protecting the personal information collected from users in the operation of these services, and have practices in place to ensure that steps are taken to maintain the security, integrity, and privacy of the personal data collected and processed. You can learn more at https://authorservices.wiley.com/statements/data-protection-policy.html.
Preprint policy:
This journal will consider for review articles previously available as preprints on non-commercial servers such as ArXiv, bioRxiv, psyArXiv, SocArXiv, engrXiv, etc. Authors are requested to update any pre-publication versions with a link to the final published article. Authors may also post the final published version of the article immediately after publication. For help with submissions, please contact: [email protected].
2. AIMS AND SCOPE
Clinical and Translational Discovery aims at being the world-leading communication channel of science related to gene and protein-based structure and function, regulation and editing, detection and diagnosis, analysis and intelligence, imaging and therapy, and ethics and regulations.
Clinical and Translational Discovery is a journal covering all aspects on clinical and translational medicine-associated discovery and development to publish the high-quality, peer-reviewed research articles, reviews, editorials, commentaries, and short communications. Clinical and Translational Discovery covers topics dedicated to the interaction and intercommunication between cells, genes, proteins, transcriptional networks, genome constructions, structures, functions, and regulations; and to the advance of gene- and protein-based editing, detection, diagnosis, analysis, intelligence, imaging, therapy, and ethics. The journal focuses on the early phase of bench to bedside approach, favoring studies and clinical observations which generate hypotheses and questions relevant to the patient and disease, and guide the investigations of clinical and translational medicine.
3. MANUSCRIPT CATEGORIES AND REQUIREMENTS
Please refer to the page for detailed requirements of each type of article.
4. PREPARING THE SUBMISSION
Cover letters
A cover letter is required, including the following information:
Parts of the Manuscript
The manuscript should be submitted in separate files: main text file; figures.
Main Text File
The text file should be presented in the following order:
Figures and supporting information should be supplied as separate files.
Authorship
Please refer to the journal’s Authorship policy in the Editorial Policies and Ethical Considerations section for details on author listing eligibility.
Abstract and Keywords
Abstracts and keywords are required for some manuscript types. For details on manuscript types that require abstracts and/or keywords, as well as how to prepare them, please refer to the ‘Manuscript Categories and Requirements’ section. The Abstract should not exceed 300 words.
Main Text
This should contain the body of the article, and may also be broken into subsections with short, informative headings. For details on manuscript types that require specific headings, please refer to the ‘Manuscript Categories and Requirements’ section.
Methods and Materials
If a method or tool is introduced in the study, including software, questionnaires, and scales, the author should state the license is available under any requirement for permission for use. If an existing method or tool is used in the research, the authors are responsible for checking the license and obtaining the permission. If permission was required, a statement confirming permission should be included in the Methods and Materials section.
Acknowledgments
Contributions from anyone who does not meet the criteria for authorship should be listed, with permission from the contributor, in an Acknowledgments section. Financial and material support should also be mentioned. Thanks to anonymous reviewers are not appropriate.
Ethics Approval and Consent to Participate: Manuscripts reporting studies involving human participants, human data or human tissue must:
Studies involving animals must include a statement on ethics approval.
If your manuscript does not report on or involve the use of any animal or human data or tissue, please state “Not applicable” in this section.
Consent for Publication: If your manuscript contains any individual person’s data in any form (including any individual details, images or videos), consent for publication must be obtained from that person, or in the case of children, their parent or legal guardian. All presentations of case reports must have consent for publication.
You can use your institutional consent form or our consent form if you prefer. You should not send the form to us on submission, but we may request to see a copy at any stage (including after publication).
If your manuscript does not contain data from any individual person, please state “Not applicable” in this section.
Conflict of Interest Statement
Authors will be asked to provide a conflict of interest statement during the submission process. For details on what to include in this section, see the ‘Conflict of Interest’ section in the Editorial Policies and Ethical Considerations section below. Submitting authors should ensure they liaise with all co-authors to confirm agreement with the final statement.
References
All references should be numbered consecutively in order of appearance and should be as complete as possible. In text citations should cite references in consecutive order using Arabic superscript numerals.
Journal titles are abbreviated; abbreviations may be found in the following: MEDLINE , Index Medicus , or CalTech Library
For more information about this reference style, please see the AMA Manual of Style.
Reference examples follow, and the full list of examples can be found here.
Journal article
King VM, Armstrong DM, Apps R, Trott JR. Numerical aspects of pontine, lateral reticular, and inferior olivary projections to two paravermal cortical zones of the cat cerebellum. J Comp Neurol 1998;390:537-551.
Book
Voet D, Voet JG. Biochemistry. New York: John Wiley & Sons; 1990. 1223 p.
Book Chapter:
Guyton JL, Crockarell JR. Fractures of acetabulum and pelvis. In: Canale ST, ed. Campbell's Operative Orthopaedics. 10th ed. Philadelphia, PA: Mosby, Inc; 2003:2939-2984.
Internet Document
American Cancer Society. Cancer Facts & Figures 2003. http://www.cancer.org/downloads/STT/CAFF2003PWSecured.pdf. Accessed March 3, 2003.
Footnotes
Footnotes should be placed as a list at the end of the paper only, not at the foot of each page. They should be numbered in the list and referred to in the text with consecutive, superscript Arabic numerals. Keep footnotes brief; they should contain only short comments tangential to the main argument of the paper and should not include references.
Always use footnotes instead of endnotes.
Tables
Tables should be self-contained and complement, not duplicate, information contained in the text. They should be supplied as editable files, not pasted as images. Legends should be concise but comprehensive – the table, legend, and footnotes must be understandable without reference to the text. All abbreviations must be defined in footnotes. Footnote symbols: †, ‡, §, ¶, should be used (in that order) and *, **, *** should be reserved for P-values. Statistical measures such as SD or SEM should be identified in the headings.
Figure Legends
Legends should be concise but comprehensive – the figure and its legend must be understandable without reference to the text. Include definitions of any symbols used and define/explain all abbreviations and units of measurement.
Figures
Although authors are encouraged to send the highest-quality figures possible, for peer-review purposes, a wide variety of formats, sizes, and resolutions are accepted.
Click here for the basic figure requirements for figures submitted with manuscripts for initial peer review, as well as the more detailed post-acceptance figure requirements.
Color figures. Figures submitted in color will be reproduced in color online free of charge. Please note, however, that it is preferable that line figures (e.g. graphs and charts) are supplied in black and white so that they are legible if printed by a reader in black and white.
Data Citation
In recognition of the significance of data as an output of research effort, Wiley has endorsed the FORCE11 Data Citation Principles. Data must be cited in the same way as article, book, and web citations and authors are required to include data citations as part of their reference list.
Data citation is appropriate for data held within institutional, subject focused, or more general data repositories. It is not intended to take the place of community standards such as in-line citation of GenBank accession codes. When citing or making claims based on data, authors should refer to the data at the relevant place in the manuscript text and in addition provide a formal citation in the reference list. We recommend the format proposed by the Joint Declaration of Data Citation Principles:
[dataset] Authors; Year; Dataset title; Data repository or archive; Version (if any); Persistent identifier (e.g. DOI)
Add [dataset] immediately before the reference so we can properly identify it as a data reference. The [dataset] identifier will not appear in your published article.
For more information about Wiley's Data Citation Policy, visit our Frequently Asked Questions page.
Additional Files
Appendices
Appendices will be published after the references. For submission they should be supplied as separate files but referred to in the text.
Supporting Information
Supporting information is information that is not essential to the article, but provides greater depth and background. It is hosted online and appears without editing or typesetting. It may include tables, figures, videos, datasets, etc.
Click here for Wiley’s FAQs on supporting information.
Note: if data, scripts, or other artefacts used to generate the analyses presented in the paper are available via a publicly available data repository, authors should include a reference to the location of the material within their paper.
General Style Points
The following points provide general advice on formatting and style.
Wiley Author Resources
Manuscript Preparation Tips: Wiley has a range of resources for authors preparing manuscripts for submission available here. In particular, we encourage authors to consult Wiley’s best practice tips on Writing for Search Engine Optimization.
Article Preparation Support
Wiley Editing Services offers expert help with English Language Editing, as well as translation, manuscript formatting, figure illustration, figure formatting, and graphical abstract design – so you can submit your manuscript with confidence.
Also, check out our resources for Preparing Your Article for general guidance about writing and preparing your manuscript.
Video Abstracts
A video abstract can be a quick way to make the message of your research accessible to a much larger audience. Wiley and its partner Research Square offer a service of professionally produced video abstracts, available to authors of articles accepted in this journal. You can learn more about it by clicking here. If you have any questions, please direct them to [email protected].
5. EDITORIAL POLICIES AND ETHICAL CONSIDERATIONS
Peer Review and Acceptance
The acceptance criteria for all papers are the quality and originality of the research and its significance to journal readership. Except where otherwise stated, manuscripts are single-blind peer reviewed, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Papers will only be sent to review if the Editors determine that the paper meets the appropriate quality and relevance requirements.
Submitted manuscripts will generally be reviewed by two or more experts who will be asked to evaluate whether the manuscript is scientifically sound and coherent, whether it duplicates already published work, and whether or not the manuscript is sufficiently clear for publication. The Editors will reach a decision based on these reports and, where necessary, they will consult with members of the Editorial Board.
In-house submissions, i.e. papers authored by Editors or Editorial Board members of the title, will be sent to Editors unaffiliated with the author or institution and monitored carefully to ensure there is no peer review bias.
Wiley's policy on the confidentiality of the review process is available here.
Guidelines on Publishing and Research Ethics in Journal Articles
The journal requires that you include in the manuscript details Institutional Review Board (IRB) approvals, ethical treatment of human and animal research participants, and gathering of informed consent, as appropriate. You will be expected to declare all conflicts of interest, or none, on submission. Please review Wiley’s policies surrounding human studies, animal studies, clinical trial registration, biosecurity, and research reporting guidelines.
This journal follows the core practices of the Committee on Publication Ethics (COPE) and handles cases of research and publication misconduct accordingly (https://publicationethics.org/core-practices).
This journal uses iThenticate’s CrossCheck software to detect instances of overlapping and similar text in submitted manuscripts. Read Wiley’s Top 10 Publishing Ethics Tips for Authors and Wiley’s Publication Ethics Guidelines.
Conflict of Interest
The journal requires that all authors disclose any potential sources of conflict of interest. Any interest or relationship, financial or otherwise that might be perceived as influencing an author's objectivity is considered a potential source of conflict of interest. These must be disclosed when directly relevant or directly related to the work that the authors describe in their manuscript. Potential sources of conflict of interest include, but are not limited to: patent or stock ownership, membership of a company board of directors, membership of an advisory board or committee for a company, and consultancy for or receipt of speaker's fees from a company. The existence of a conflict of interest does not preclude publication. If the authors have no conflict of interest to declare, they must also state this at submission. It is the responsibility of the corresponding author to review this policy with all authors and collectively to disclose with the submission ALL pertinent commercial and other relationships.
Funding
Authors should list all funding sources in the Declarations section. Authors are responsible for the accuracy of their funder designation. If in doubt, please check the Open Funder Registry for the correct nomenclature: https://www.crossref.org/services/funder-registry/.
Authorship
The journal follows the ICMJE definition of authorship, which indicates that authorship be based on the following 4 criteria:
In addition to being accountable for the parts of the work he or she has done, an author should be able to identify which co-authors are responsible for specific other parts of the work. In addition, authors should have confidence in the integrity of the contributions of their co-authors.
All those designated as authors should meet all four criteria for authorship, and all who meet the four criteria should be identified as authors. Those who do not meet all four criteria should be acknowledged. These authorship criteria are intended to reserve the status of authorship for those who deserve credit and can take responsibility for the work. The criteria are not intended for use as a means to disqualify colleagues from authorship who otherwise meet authorship criteria by denying them the opportunity to meet criterion #s 2 or 3. Therefore, all individuals who meet the first criterion should have the opportunity to participate in the review, drafting, and final approval of the manuscript.
Authors' information
You may choose to use this section to include any relevant information about the author(s) that may aid the reader's interpretation of the article, and understand the standpoint of the author(s). This may include details about the authors' qualifications, current positions they hold at institutions or societies, or any other relevant background information. Note this section should not be used to describe any competing interests.
Acknowledgements
Please acknowledge anyone who contributed towards the article who does not meet the criteria for authorship including anyone who provided professional writing services or materials.
Authors should obtain permission to acknowledge from all those mentioned in the Acknowledgements section.
If you do not have anyone to acknowledge, please write "Not applicable" in this section.
Group authorship (for manuscripts involving a collaboration group): if you would like the names of the individual members of a collaboration Group to be searchable through their individual PubMed records, please ensure that the title of the collaboration Group is included on the title page and in the submission system and also include collaborating author names as the last paragraph of the “Acknowledgements” section. Please add authors in the format First Name, Middle initial(s) (optional), Last Name. You can add institution or country information for each author if you wish, but this should be consistent across all authors.
Please note that individual names may not be present in the PubMed record at the time a published article is initially included in PubMed as it takes PubMed additional time to code this information.
Data Sharing and Data Accessibility
Please review Wiley's policy here. This journal encourages data sharing.
Clinical and Translational Discovery recognizes the many benefits of archiving research data. Clinical and Translational Discovery encourages you to archive all the data from which your published results are derived in a public repository. The repository that you choose should offer you guaranteed preservation (see the registry of research data repositories at https://www.re3data.org/) and should help you make it findable, accessible, interoperable, and re-useable, according to FAIR Data Principles (https://www.force11.org/group/fairgroup/fairprinciples).
Human subject information in databases. The journal refers to the World Health Medical Association Declaration of Taipei on Ethical Considerations Regarding Health Databases and Biobanks.
Species Names
Upon its first use in the title, abstract, and text, the common name of a species should be followed by the scientific name (genus, species, and authority) in parentheses. For well-known species, however, scientific names may be omitted from article titles. If no common name exists in English, only the scientific name should be used.
Genetic Nomenclature
Sequence variants should be described in the text and tables using both DNA and protein designations whenever appropriate. Sequence variant nomenclature must follow the current HGVS guidelines; see varnomen.hgvs.org, where examples of acceptable nomenclature are provided.
Sequence Data
Nucleotide sequence data can be submitted in electronic form to any of the three major collaborative databases: DDBJ, EMBL, or GenBank. It is only necessary to submit to one database as data are exchanged between DDBJ, EMBL, and GenBank on a daily basis. The suggested wording for referring to accession-number information is: ‘These sequence data have been submitted to the DDBJ/EMBL/GenBank databases under accession number U12345’. Addresses are as follows:
Proteins sequence data should be submitted to either of the following repositories:
Structural Data
For papers describing structural data, atomic coordinates and the associated experimental data should be deposited in the appropriate databank (see below). Please note that the data in databanks must be released, at the latest, upon publication of the article. We trust in the cooperation of our authors to ensure that atomic coordinates and experimental data are released on time.
Publication Ethics
This journal follows the core practices of the Committee on Publication Ethics (COPE) and handles cases of research and publication misconduct accordingly (https://publicationethics.org/core-practices).
Note this journal uses iThenticate’s CrossCheck software to detect instances of overlapping and similar text in submitted manuscripts. Read Wiley’s Top 10 Publishing Ethics Tips for Authors here. Wiley’s Publication Ethics Guidelines can be found here.
ORCID
Please see Wiley’s resources on ORCID here.
As part of the journal’s commitment to supporting authors at every step of the publishing process, the journal requires the submitting author (only) to provide an ORCID iD when submitting a manuscript. This takes around 2 minutes to complete. Find more information here.
6. Author Licensing
Clinical and Translational Discovery is an Open Access journal and accepted articles are published under Creative Commons Attribution License (CC BY). With CC BY, the author retains copyright and the public is allowed to reuse the content. The author grants Wiley a license to publish the article and to identify as the original publisher.
While Clinical and Translational Discovery does not charge any submission fees, authors of accepted articles are asked to pay an Article Publication Charge to cover publication costs. Information on the Article Publication Charge for publishing in the journal is here.
If a paper is accepted for publication, the author identified as the formal corresponding author will receive an email prompting them to login to Author Services, where via the Wiley Author Licensing Service (WALS), they will be able to complete the license agreement on behalf of all authors on the paper.
To learn more about Creative Commons Licenses and to preview terms and conditions of the agreements, please click here. Note that certain funders mandate a particular type of CC license be used; to check this, please click here.
7. PUBLICATION PROCESS AFTER ACCEPTANCE
Accepted Article Received in Production
When an accepted article is received by Wiley’s production team, the corresponding author will receive an email asking them to login or register with Wiley Author Services. The author will be asked to sign a publication license at this point.
Proofs
Authors will receive an e-mail notification with a link and instructions for accessing HTML page proofs online. Page proofs should be carefully proofread for any copyediting or typesetting errors. Online guidelines are provided within the system. No special software is required, all common browsers are supported. Authors should also make sure that any renumbered tables, figures, or references match text citations and that figure legends correspond with text citations and actual figures. Proofs must be returned within 48 hours of receipt of the email. Return of proofs via e-mail is possible in the event that the online system cannot be used or accessed.
Early View
The journal offers rapid publication via Wiley’s Early View service. Early View (Online Version of Record) articles are published on Wiley Online Library before inclusion in an issue. Note there may be a delay after corrections are received before the article appears online, as Editors also need to review proofs. Before we can publish an article, we require a signed license (authors should login or register with Wiley Author Services. Once the article is published on Early View, no further changes to the article are possible. The Early View article is fully citable and carries an online publication date and DOI for citations.
8. POST PUBLICATION
Access and Sharing
Please review Wiley’s guidelines on sharing your research here. The submitted version of the manuscript, the accepted version, and the published version (Version of Record) can all be deposited on an institutional or other repository of the author's choice without embargo.
When the article is published online:
Promoting the Article
To find out how to best promote an article, click here.
Article Promotion Support
Wiley Editing Services offers professional video, design, and writing services to create shareable video abstracts, infographics, conference posters, lay summaries, and research news stories for your research – so you can help your research get the attention it deserves.
Measuring the Impact of an Article
Wiley also helps authors measure the impact of their research through specialist partnerships with Kudos and Altmetric.
Archiving Services
Portico and CLOCKSS are digital archiving/preservation services we use to ensure that Wiley content will be accessible to customers in the event of a catastrophic event such as Wiley going out of business or the platform not being accessible for a significant period of time. Member libraries participating in these services will be able to access content after such an event. Wiley has licenses with both Portico and CLOCKSS, and all journal content gets delivered to both services as it is published on Wiley Online Library. Depending on their integration mechanisms, and volume loads, there is always a delay between content being delivered and showing as “preserved” in these products.
9. EDITORIAL OFFICE CONTACT DETAILS
Shanghai Institute of Clinical Bioinformatics
No. 446, Zhaojiabang Road, Xuhui District,
Shanghai 200031, China
Email: office@ctmworld.org
Author Guidelines updated in Mar 2022