Potential diagnostic and distinguishing roles of microneedle-based biosensors in bacterial and aseptic meningitis

Abstract

Meningitis, which is defined by inflammation of the meninges, is a major cause of death and morbidity worldwide. Traditional diagnostic approaches, such as imaging procedures and the study of cerebrospinal fluid, are intrusive, time consuming and sometimes non-specific. The suggested approach entails creating a biosensor based on microneedles that can detect in real time without the requirement for labels. The biosensor uses highly sensitive detection techniques to detect changes in ionic current and modulation of impedance in response to biomolecules that are of interest, such as proteins and nucleic acids, which are linked to meningitis infections. Initial studies have shown that the microneedle-based biosensor for meningitis diagnosis is both feasible and effective. When it comes to identifying bacterial and aseptic meningitis biomarkers from blood and cerebrospinal fluid (CSF) samples, the biosensor showed excellent sensitivity and specificity. This novel technique has the potential to enhance patient outcomes by facilitating prompt intervention and tailored therapy by offering a quick, safe and accurate way to distinguish between bacterial and aseptic meningitis. To maximise the biosensor's performance and confirm its therapeutic usefulness in various contexts, more investigations and advancements are necessary.

References

[1] Yekani M, Memar MY. Immunologic biomarkers for bacterial meningitis. Clin Chim Acta. 2023;548:117470.

[2] Mace SE. Acute bacterial meningitis. Emerg Med Clin North Am. 2008;26(2):281-317.

[3] Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743-800.

[4] Davis LE. Acute bacterial meningitis. Continuum (Minneap Minn). 2018;24(5):1264-1283.

[5] Mintegi S, García S, Martín MJ, et al. Clinical prediction rule for distinguishing bacterial from aseptic meningitis. Pediatrics. 2020;146(3):e20201126.

[6] Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M. Aseptic meningitis. Rev Neurol. 2019;175(7-8):475-480.

[7] Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D. Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. Lancet. 2012;380(9854):1684-1692.

[8] Tunkel AR, Waltham MA. Aseptic Meningitis in Adults. 2018.

[9] Bahr NC, Boulware DR. Methods of rapid diagnosis for the etiology of meningitis in adults. Biomark Med. 2014;8(9):1085-1103.

[10] Poplin V, Boulware DR, Bahr NC. Methods for rapid diagnosis of meningitis etiology in adults. Biomark Med. 2020;14(6):459-479.

[11] Dubos F, Korczowski B, Aygun DA, et al. Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules. Arch Dis Child. 2010;95(12):963-967.

[12] Ray P, Badarou-Acossi G, Viallon A, et al. Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear. Am J Emerg Med. 2007;25(2):179-184.

[13] Thwaites G, Chau T, Stepniewska K, et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet. 2002;360(9342):1287-1292.

[14] Hasbun R, Rosenthal N, Balada-Llasat J, et al. Epidemiology of meningitis and encephalitis in the United States, 2011–2014. Clin Infect Dis. 2017;65(3):359-363.

[15] Sulaiman T, Salazar L, Hasbun R. Acute versus subacute community-acquired meningitis: analysis of 611 patients. Medicine. 2017;96(36):e7984.

[16] Mohan S, Jain KK, Arabi M, Shah GV. Imaging of meningitis and ventriculitis. Neuroimag Clin N Am. 2012;22(4):557-583.

[17] Esfandyarpour R, Esfandyarpour H, Javanmard M, Harris JS, Davis RW. Microneedle biosensor: a method for direct label-free real time protein detection. Sens Actuators B, Chem. 2013;177:848-855.

[18] Dixon RV, Lau WM, Moghimi SM, Ng KW. The diagnostic potential of microneedles in infectious diseases. Precision Nanomed. 2020;3(3):629-640.

[19] Liu G-S, Kong Y, Wang Y, et al. Microneedles for transdermal diagnostics: recent advances and new horizons. Biomaterials. 2020;232:119740.

[20] Dixon RV, Skaria E, Lau WM, et al. Microneedle-based devices for point-of-care infectious disease diagnostics. Acta Pharm Sin B. 2021;11(8):2344-2361.

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2024 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.