Synthesis of Chiral Diamides via IDPA Catalyzed Dynamic Kinetic Resolution of Oxazolidinones

Abstract

The synthesis of non-natural amino acids and their derivatives remains a prominent research topic in organic synthesis. Dynamic kinetic resolution of oxazolidinones was successfully achieved via asymmetric aminolysis catalyzed by chiral imidodiphosphoric acids, affording chiral diamides with high yields and enantioselectivities (up to 83% yield, 95% e.e.). This protocol provides a concise and efficient strategy for the preparation of enantioenriched chiral diamides.

Keywords

Chiral diamide / Chiral imidodiphosphoric acid / Oxazolidinone / Dynamic kinetic resolution

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