Formation of Electrospun Membranes with High Resilience by In situ Crosslinking

Abstract

Elasticity of biodegradable fibrous scaffolds is one of essential requirements for soft tissue regeneration, and sufficient compliance of small-diameter vascular grafts is necessary. In this work, electrospun fibrous membranes with high resilience are prepared through blend electrospinning of poly(ε-caprolactone) (PCL)/methacrylated poly(glycerol sebacate) (PGS) and in situ photo-crosslinking with poly(ethylene glycol) diacrylate. The obtained PCL/PGS electrospun membranes have minor hemolysis, low platelet adherence, and favorable cytocompatibility. In the wet state, the PCL/PGS electrospun membranes in 5/5 or 4/6 mass ratio exhibit lowered modulus and reversible deformation with improved compliance in comparison with PCL, which can be comparable to the human saphenous vein. This study provides a feasible way to prepare electrospun fibrous scaffolds with high elasticity, that can be suitable for applications in vascular regeneration and relative soft tissue repair.

Keywords

Poly(glycerol sebacate) / Poly(ε-caprolactone) / Blend electrospinning / In situ crosslinking / Mechanical property

References

[1] PedersenD D, KimS, WagnerW RJ. Biomed. Mater. Res., 2022, 110: 1460.

[2] ChenS, WangY, YangL, ChuC, CaoS, WangZ, XueJ, YouZProg. Polym. Sci., 2023, 147: 101763.

[3] JiaY, XuX, LuH, FatimaK, ZhangY, DuH, YangJ, ZhouX, SuiX, HouL, PangY, HeCBiomaterials, 2025, 316: 122985.

[4] BaiS, ZhangX, ZangL, YangS, ChenX, YuanXChem. Res. Chinese Universities, 2021, 37: 394.

[5] WangZ, ZhengW, WuY, WangJ, ZhangX, WangK, ZhaoQ, KongD, KeT, LiCBiomater. Sci., 2016, 4: 1485.

[6] ZhuM, WuY, LiW, DongX, ChangH, WangK, WuP, ZhangJ, FanJ, WangL, LiuJ, WangH, KongDBiomaterials, 2018, 183: 306.

[7] ZhangX, BaiS, ZangL, ChenX, YuanXChem. Res. Chinese Universities, 2022, 38: 1111.

[8] AllenR A, WuW, YaoM, DuttaD, DuanX, BachmanT N, ChampionH C, StolzD B, RobertsonA M, KimK, IsenbergJ S, WangYBiomaterials, 2014, 35: 165.

[9] JeffriesE M, AllenR A, GaoJActa Biomater., 2015, 18: 30.

[10] WuZ, JinK, WangL, FanYMacromol. Biosci., 2021, 21: 2100022.

[11] WangZ, ZhangM, LiuL, MithieuxS M, WeissA SJ. Biomed. Mater. Res. Part A, 2024, 112: 574.

[12] ZhuT, GuH, ZhangH, WangH, XiaH, MoX, WuJActa Biomater., 2021, 119: 211.

[13] BaiS, ZhangX, ZangL, RenL, YuanXSci. China Tech. Sci., 2022, 65: 2751.

[14] ZangL, ChengQ, BaiS, WangK, YuanXJ. Biomater. Sci. Polym. Ed., 2023, 34: 1171.

[15] GaoY, BaiS, ZhuK, YuanXJ. Biomater. Sci. Polym. Ed., 2024, 35: 1157.

[16] WangY, AmeerG A, SheppardB J, LangerRNat. Biotechnol., 2002, 20: 602.

[17] GodinhoB, GamaN, FerreiraAFront. Bioeng. Biotechnol., 2022, 10: 1033827.

[18] YuL, ZengG, XuJ, HanM, WangZ, LiT, LongM, WangL, HuangW, WuYPolym. Rev., 2023, 63: 613.

[19] SantS, IyerD, GaharwarA K, PatelA, KhademhosseiniAActa Biomater., 2013, 9: 5963.

[20] WuZ, WangL, FanYJ. Biomed. Mater. Res. A, 2023, 111: 1513.

[21] ChenW, XiaoW, LiuX, YuanP, ZhangS, WangY, WuWBioact. Mater., 2022, 11: 283

[22] MasoumiN, LarsonB L, AnnabiN, KharazihaM, ZamanianB, ShaperoK S, GubberleyA T, Camci-UnalG, ManningK B, MayerJ EJr., KhademhosseiniAAdv. Healthcare Mater., 2014, 3: 929.

[23] KhosraviR, BestC A, AllenR A, StowellC E T, OnwukaE, ZhuangJ J, LeeY U, YiT, BersiM R, ShinokaT, HumphreyJ D, WangY, BreuerC KAnn. Biomed. Eng., 2016, 44: 2402.

[24] FerrariP F, AliakbarianB, BarisioneC, KahnC J F, Arab-TehranyE, PalomboDJ. Biomed. Mater. Res. A, 2023, 111: 1500.

[25] LorioF, KhatibM E, WöltingerN, TurrianiM, GiacintoO D, MauroA, RussoV, BarboniB, BoccacciniA RJ. Biomed. Mater. Res. A, 2025, 113: e37794.

[26] WangM, LeiD, LiuZ, ChenS, SunL, LvZ, HuangP, JiangZ, YouZJ. Biomater. Sci. Polym. Ed., 2017, 28: 1728.

[27] WuY, WangL, GuoB, MaP XJ. Mater. Chem. B, 2014, 2: 3674.

[28] HanW-H, WangQ-Y, KangY-Y, ShiL-R, LongY, ZhouX, HaoC-CNanoscale, 2023, 15: 15513.

[29] NiuQ, GaoS, ZhuK, RenL, YuanXSci. China Tech. Sci., 2024, 67: 1160.

[30] LiZ, HuW, ZhaoY, RenL, YuanXColloids Surf. B, 2018, 169: 151.

[31] LiS, YangL, ZhaoZ, YangX, LvHActa Biomater., 2024, 176: 234.

[32] OzdemirS, OztemurJ, SezginH, Yalcin-EnisIACS Biomater. Sci. Eng., 2024, 10: 960.

[33] Yuan L., Gao Y., Wang Q., Zhu K., Ren L., Yuan X., Acta Biomater, 2025, https://doi.org/10.1016/j.actbio.2025.02.031.

[34] ZhouS, LiuY, YuX, WangD, WangX, LiQACS Appl. Bio. Mater., 2024, 7: 6985.

[35] BrashJ L, HorbettT A, LatourR A, TengvellPActa Biomater., 2019, 94: 11.

[36] GorbetM, SperlingC, MaitzM FActa. Biomater., 2019, 94: 25.

[37] L’HeureuxN, DusserreN, KonigG, VictorB, KeireP, WightT N, ChronosN A F, KylesA E, GregoryC R, HoytG, RobbinsR C, McAllisterT NNat. Med., 2006, 12: 361.

[38] HiobM A, SheS, MuiznieksL D, WeissA SACS Biomater. Sci. Eng., 2017, 3: 712.

[39] McClureM J, SimpsonD G, BowlinG LJ. Mech. Behav. Biomed., 2012, 10: 48.

RIGHTS & PERMISSIONS

Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH