Regulation of Tumor Microenvironment Under Malignant Conditions: Application of nMOFs in Sonodynamic Therapy

Abstract

In this review, we delve into the intricate regulation of the tumor microenvironment (TME) under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks (nMOFs) in the realm of sonodynamic therapy (SDT). The TME serves as a dynamic milieu influencing tumor progression and therapeutic response, presenting formidable challenges, such as hypoxia, acidity, excess hydrogen peroxide, high expression of glutathione, and immunosuppression. Utilizing the exceptional attributes of nMOFs, including their tunable structures and biocompatibility, holds immense promise for enhancing SDT efficacy and reshaping the TME landscape. By integrating nMOFs with SDT, researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable TME conditions and immune resistance. The potential of nMOFs to revolutionize tumor therapies by precisely targeting TME and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate TME to amplify the efficacy of SDT.

Keywords

Sonodynamic therapy / Metal-organic framework / Tumor microenvironment / Modification of sonosensitizer

References

[1] Martínez-Jiménez F, Muiños F, Sentís I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, Mularoni L, Pich O, Bonet J, Kranas H, Gonzalez-Perez A, Lopez-Bigas N. . Nat. Rev. Cancer, 2020, 20: 555,

[2] Ugai T, Sasamoto N, Lee H -Y, Ando M, Song M, Tamimi R M, Kawachi I, Campbell P T, Giovannucci E L, Weiderpass E, Rebbeck T R, Ogino S. . Nat. Rev. Clin. Oncol., 2022, 19: 656,

[3] Shi J, Kantoff P W, Wooster R, Farokhzad O C. . Nat. Rev. Cancer, 2017, 17: 20,

[4] Faguet G B. . Int. J. Cancer, 2015, 136: 2022,

[5] Guo Q, Dai X, Yin M, Cheng H, Qian H, Wang H, Zhu D, Wang X. . Military Med. Res., 2022, 9: 26,

[6] Xu M, Zhou L, Zheng L, Zhou Q, Liu K, Mao Y, Song S. . Cancer Lett., 2021, 497: 229,

[7] Canaparo R, Foglietta F, Barbero N, Serpe L. . Adv. Drug Deliv. Rev., 2022, 189: 114495,

[8] Qian X, Zheng Y, Chen Y. . Adv. Mater., 2016, 28: 8097,

[9] Trachootham D, Alexandre J, Huang P. . Nat. Rev. Drug. Discov., 2009, 8: 579,

[10] Fan H, Guo Z. . Coord. Chem. Rev., 2023, 480: 215027,

[11] Wang S, Song Y, Cao K, Zhang L, Fang X, Chen F, Feng S, Yan F. . Acta Biomater., 2021, 134: 621,

[12] Visser K E D, Joyce J A. . Cancer cell, 2023, 41: 374,

[13] Chao Y, Liu Z. . Nat. Rev. Bioeng, 2023, 1: 125,

[14] Song L, Lu L, Pu Y, Yin H, Zhang K. . Acc. Mater. Res., 2022, 3: 971,

[15] Tao N, Li H, Deng L, Zhao S, Ouyang J, Wen M, Chen W, Zeng K, Wei C, Liu Y. . ACS Nano, 2022, 16: 485,

[16] Wang T, Peng W, Du M, Chen Z. . Front. Oncol., 2023, 13: 1167105,

[17] Yuan H, Ma J, Huang W, Gong P, Shi F, Xu X, Fu C, Wang X, Wong Y K, Long Y, Sun X, Li W, Li Z, Wang J. . JACS Au, 2023, 3: 1507,

[18] Zhang Z, Li B, Xie L, Sang W, Tian H, Li J, Wang G, Dai Y. . ACS Nano, 2021, 15: 16934,

[19] Umemura S, Yumita N, Nishigaki R, Umemura K. . Jpn. J. Cancer Res., 1990, 81: 962,

[20] Son S, Kim J H, Wang X, Zhang C, Yoon S A, Shin J, Sharma A, Lee M H, Cheng L, Wu J, Kim J S. . Chem. Soc. Rev., 2020, 49: 3244,

[21] Bindra A K, Wang D, Zhao Y. . Adv. Mater., 2023, 35: 2300700,

[22] Gao P, Chen Y, Pan W, Li N, Liu Z, Tang B. . Angew. Chem. Int. Ed., 2021, 60: 2,

[23] Sun Y, Zheng L, Yang Y, Qian X, Fu T, Li X, Yang Z, Yan H, Cui C, Tan W. . Nano-Micro Lett., 2020, 12: 103,

[24] Huang S, Kou X, Shen J, Chen G, Ouyang G. . Angew. Chem. Int. Ed., 2020, 590: 59

[25] Yang F, Dong J, Li Z, Wang Z. . ACS Nano, 2023, 17: 4102,

[26] Jiang Q, Gao X, Zhang W, Chen Z. . Biomater. Sci., 2023, 11: 4452,

[27] Tang J, Huang C, Liu Y, Wang T, Yu M, Hao H, Zeng W, Huang W, Wang J, Wu M. . Coord. Chem. Rev., 2023, 490: 215211,

[28] Ge X, Wong R, Anisa A, Ma S. . Biomaterials, 2022, 281: 121322,

[29] Guo W, Wang Y, Zhang K, Dai X, Qiao Z, Liu Z, Yu B, Zhao N, Xu F. . Chem. Mater., 2023, 35: 6853,

[30] Liao D, Huang J, Jiang C, Zhou L, Zheng M. . Pharmaceutics, 2023, 15: 2071,

[31] Ravi K, Manoharan T J M, Wang K, Pockaj B, Nikkhah M. . Biomaterials, 2024, 305: 122428,

[32] Zhang Z, Ding C, Sun T, Wang L, Chen C. . Adv. Healthc. Mater., 2023, 12: 2300153,

[33] Coluccia M, Parisse V, Guglielmi P, Giannini G, Secci D. . Eur. J. Med. Chem., 2022, 244: 114801,

[34] Ouyang J, Tang Z, Farokhzad N, Kong N, Kim N Y, Feng C, Blake S, Xiao Y, Liu C, Xie T, Tao W. . Naonotoday, 2020, 35: 100949,

[35] Lentacker I, Cock D, Deckers R, Smedt S C D, Moonen C T W. . Adv. Drug Deliv. Rev., 2014, 72: 49,

[36] Chowdhury S M, Abou-Elkacem L, Lee T, Dahl J, Lutz A M. . J. Control. Release, 2020, 326: 75,

[37] Kooiman K, Roovers S, Langeveld S A G, Kleven R T, Dewitte H, O’Reilly M A, Escoffre J-M, Bouakaz A, Verweij M D, Hynynen K, Lentacke I, Stride E, Holland C K. . Ultrasound Med. Biol., 2020, 44: 1296,

[38] Yang H, Villani R M, Wang H, Simpson M J, Roberts M S, Tang M, Liang X. . J. Exp. Clin. Cancer Res., 2018, 37: 266,

[39] Cheung E C, Vousden K H. . Nat. Rev. Cancer, 2022, 22: 280,

[40] Dong Y, Dong S, Liu B, Yu C, Liu J, Yang D, Yang P, Lin J. . Adv. Mater., 2021, 33: 2106838,

[41] Hiam-Galvez K J, Allen B M, Spitzer M H. . Nat. Rev. Cancer, 2021, 21: 345,

[42] Zhu S, Zhang T, Zheng L, Liu H, Song W, Liu D, Li Z, Pan C. . J. Hematol. Oncol., 2021, 114: 156,

[43] Yin Y, Jiang X, Sun L, Li H, Su C, Zhang Y, Xu G, Li X, Zhao C, Chen Y, Xu H, Zhang K. . Nanotoday, 2021, 36: 101009,

[44] Yang Y, Huang J, Liu M, Qiu Y, Chen Q, Zhao T, Xiao Z, Yang Y, Jiang Y, Huang Q, Ai K. . Adv. Sci., 2023, 10: 2204365,

[45] Wang T, Peng W, Du M, Chen Z. . Front. Oncol., 2023, 13: 1167105,

[46] Li D, Yang Y, Li D, Pan J, Chu C, Liu G. . Small, 2021, 17: 2101976,

[47] Lin X, Song J, Chen X, Yang H. . Angew. Chem. Int. Ed., 2019, 59: 14212,

[48] Xing X, Zhao S, Xu T, Huang L, Zhang Y, Lan M, Lin C, Zheng X, Wang P. . Coord. Chem. Rev., 2021, 445: 214087,

[49] Liu K, Jiang Z, Zhao F, Wang W, Jäkle F, Wang N, Tang X, Yin X, Chen P. . Adv. Mater., 2022, 34: 2206594,

[50] Qian X, Zheng Y, Chen Y. . Adv. Mater., 2016, 28: 8097,

[51] Chewn H, Liu L, Ma A, Yin T, Chen Z, Liang R, Qiu Y, Zheng M, Cai L. . Biomaterials, 2021, 269: 120639,

[52] Teranishi R, Matsuda T, Yuba E, Kono K, Harada A. . Macromol. Biosci., 2019, 19: 1800365,

[53] Zhang D, Chen B P Y, Liu H, Shi Y, Chen L, Kankala R K, Wang S, Chen A. . Mater. Des., 2023, 227: 111794,

[54] Li Y, Huang C, Xu Y. . Front. Bioeng. Biotechnol., 2022, 10: 1069676,

[55] Hu W, Wang S, Jiang C, Zheng M, Bai Z, Srivastava D, Kumar A, Liu J. . Dyes Pigment., 2023, 219: 111596,

[56] Wang X, Zhong X, Bai L, Xu J, Gong F, Dong Z, Yang Z, Zeng Z, Liu Z, Cheng L. . J. Am. Chem. Soc., 2020, 142: 6527,

[57] Liu Y, Wang Y, Zhen W, Wang Y, Zhang S, Zhao Y, Song S, Wu Z, Zhang H. . Biomaterials, 2020, 251: 120075,

[58] Deepagan V G, You D G, Um W, Ko H, Kwon S, Choi K Y, Yi G, Lee J Y, Lee D S, Kim K, Kwon I C, Park J H. . Nano Lett., 2016, 16: 6257,

[59] Xu T, Zhao S, Lin C, Zheng X, Lan M. . Nano Res., 2020, 13: 2898,

[60] Qiao X, Xue L, Huang H, Dai X, Chen Y, Ding H. . J. Nanobiotechnol., 2022, 20: 186,

[61] Cao Z, Yuan G, Zeng L, Bai L, Liu X, Wu M, Sun R, Chen Z, Jiang Y, Gao Q, Chen Y, Zhang Y, Pan Y, Wang J. . ACS Nano, 2022, 16: 10608,

[62] Pandey A, Dhas N, Deshmukh P, Caro C, Patil P, García-Martín M L, Padya B, Nikam A, Mehta T, Mutalik S. . Coord. Chem. Rev., 2020, 409: 213212,

[63] Cao J, Huang D, Peppas N A. . Adv. Drug Deliv., 2020, 167: 170,

[64] Wang Z, Sun Q, Liu B, Kuang Y, Gulzar A, He F, Gai S, Yang P, Lin J. . Coord. Chem. Rev., 2021, 439: 213945,

[65] Ye Y, Zhao Y, Sun Y, Cao J. . Int. J. Nanomed., 2022, 17: 2367,

[66] Hu W, Wang S, Jiang C, Zheng M, Bai Z, Srivastava D, Kumar A, Liu J. . Dyes Pigm., 2023, 219: 111596,

[67] Anderson S L, Stylianou K C. . Coord. Chem. Rev., 2017, 349: 102,

[68] Zhang Y, Wang F, Liu C, Wang Z, Kang L, Huang Y, Dong K, Ren J, Qu X. . ACS Nano, 2018, 12: 651,

[69] Zheng Y, Zhang X, Su Z. . Nanoscale, 2021, 13: 12102,

[70] Song Y, Zhang L, Wang Y, Han M, Wang Z, Wang N, Shao B, Li R, Cao K, Song M, Du Y, Yan F. . Adv. Mater., 2023, 35: 2210895,

[71] Zeng Y, Ouyang Q, Yu Y, Tan L, Liu X, Zheng Y, Wu S. . Small Methods, 2022, 7: 2201248,

[72] Liang S, Xiao X, Bai L, Liu B, Yuan M, Ma P, Pang M, Cheng Z, Lin J. . Adv. Mater., 2021, 33: 2100333,

[73] Liu S, Wen M, Huang M, Wang H, Chen Z, Yu N. . J. Colloid Interface Sci., 2022, 616: 23,

[74] Hu C, Wang J, Liu S, Cai L, Zhou Y, Liu X, Wang M, Liu Z, Pang M. . ACS Appl. Mater. Interfaces, 2021, 13: 4825,

[75] Lin G, Nash G T, Luo T, Ghosh I, Sohoni S, Christofferson A J, Liu G, Engel G S, Lin W. . Adv. Mater., 2023, 35: 2212069,

[76] Meng X, Sun S, Gong C, Yang J, Yang Z, Zhang X, Dong H. . ACS Nano, 2023, 17: 1174,

[77] Li H, Zhou L, Zhou J, Li Q, Ji Q. . J. Exp. Clin. Cancer Res., 2021, 40: 97,

[78] DePeaux K, Delgoffe G M. . Nat. Rev. Immunol., 2021, 21: 785,

[79] Godet I, Shin Y J, Ju J A, Ye I C, Wang G, Gilkes D M. . Nat. Commun., 2019, 10: 4862,

[80] Zhang T, Sun Y, Cao J, Luo J, Wang J, Jiang Z, Huang P. . J. Nanobiotechnol., 2021, 19: 315,

[81] Xu Q, Zhan G, Zhang Z, Yong T, Yang X, Gan L. . Theranostics, 2021, 11: 1937,

[82] Liu X, Dong X, Yang S, Lai X, Liu H, Gao Y, Feng H, Zhu M, Yuan Y, Lu Q, Lovell J F, Chen H, Fang C. . Adv. Sci., 2021, 8: 2003679,

[83] Bao Y, Chen J, Qiu H, Zhang C, Huang P, Mao Z, Tong W. . ACS Appl. Mater. Interfaces, 2021, 13: 24532,

[84] Sulea T, Rohani N, Baardsnes J, Corbeil C R, Deprez C, Cepero-Donates Y, Robert A, Schrag J D, Parat M, Duchesne M, Jaramillo M L, Purisima E O, Zwaagstra J C. . Mabs, 2021, 12: 1682866,

[85] Ren Q, Yu N, Wang L, Wen M, Geng P, Jiang Q, Li M. . J. Colloid Interface Sci., 2022, 614: 147,

[86] Dong Z, Feng L, Hao Y, Li Q, Chen M, Yang Z, Zhao H, Liu Z. . Chem, 2020, 6: 1391,

[87] Chu Z, Yang J, Zheng W, Sun J, Wang W, Qian H. . Coord. Chem. Rev., 2023, 481: 215049,

[88] Yang N, Xiao W, Song X, Wang W, Dong X. . Nano-Micro Lett., 2020, 12: 15,

[89] Zhang H, Zhang Y, Li Y, Hu M, Rong Z, Meng L, Zhang X, Wen L, Liang X, Chen Z, Liu C. . Adv. Therap., 2023, 6: 2300074,

[90] Hang L, Li M, Zhang Y, Li W, Fang L, Chen Y, Zhou C, Qu H, Shao L, Jiang G. . Small, 2023 2306364

[91] Wang Y, Huang K, Wang T, Liu L, Yu F, Sun W, Yao W, Xiong H, Liu X, Jiang H, Wang X. . Small, 2024 2310300

[92] Li M, Huo L, Zeng J, Zhu G, Shi S, Liu X, Zhu X, Huang G, Qiu D, Jia J, Ni K, Zhao Z. . Chem. Eng. J., 2022, 440: 135966,

[93] Fang L, Han M, Zhang Y, Song Y, Liu B, Cai M, Jiang M, Hu L, Zheng R, Lian X, Yan F, Huang K, Feng S. . Adv. Healthc. Mater., 2023, 12: 2300134,

[94] Jiang S, He Q, Li C, Dang K, Ye L, Zhang W, Tian Y. . Sci. China Mater., 2022, 65: 1112,

[95] Zhang K, Meng X, Yang Z, Dong H, Zhang X. . Biomaterials, 2020, 258: 120278,

[96] Zhou L, Feng W, Mao Y, Chen Y, Zhang X. . Bioact. Mater., 2023, 24: 26

[97] Jia T, Du J, Yang J, Li Y, Ohulchanskyy T Y, Fang X, Chen G. . Adv. Funct. Mater., 2023, 34: 2307816,

[98] Xu X, Chen M, Jiang S, Pan Z, Zhao C. . Adv. Funct. Mater., 2024 2314780

[99] Zhou Y, Jiao J, Yang R, Wen B, Wu Q, Xu L, Tong X, Yan H. . Clin. Immunol., 2023, 256: 109772,

[100] Wang T, Peng W, Du M, Chen Z. . Front. Oncol., 2023, 13: 1167105,

[101] Wang Y, Gong F, Han Z, Lei H, Zhou Y, Cheng S, Yang X, Wang T, Wang L, Yang N, Liu Z, Cheng L. . Angew. Chem. Int. Ed., 2023, 62: e202215467,

[102] Chen C, Song M, Du Y, Yu Y, Li C, Han Y, Yan F, Shi Z, Feng S. . Nano Lett., 2021, 21: 5522,

[103] Luo J, Wang X, Shi Z, Zeng Y, He L, Cao J, Sun Y, Zhang T, Huang P. . J. Nanobiotechnol, 2022, 20: 228,

[104] Lu Z, Bai S, Jiang Y, Wu S, Xu D, Zhang J, Peng X, Zhang H, Shi Y, Liu G. . Small, 2022, 18: 2203952,

[105] Liu L, Pan Y, Zhao C, Huang P, Chen X, Rao L. . ACS Nano, 2023, 17: 3225,

[106] Du Y, Dai X, Han M, Wang Z, Wang Y, Shi Z, Yan F, Feng S. . Chem. Eng. J., 2023, 453: 139635,

[107] Li Q, Su R, Bao X, Cao K, Du Y, Wang N, Wang J, Xing F, Yan F, Huang K, Feng S. . Acta Biomater., 2022, 144: 109,

[108] Zhou X, Ni Y, Liang X, Lin Y, An B, He X, Zhao X. . Front. Immunol., 2022, 13: 915094,

[109] Dai X, Li X, Liu Y, Yan F. . Mater. Des., 2022, 217: 110656,

[110] Dan X, Du Y, Li Y, Yan F. . Mater. Today Bio, 2023, 23: 100796,

[111] Heinhuis K M, Ros W, Kok M, Steeghs N, Beijnen J H, Schellens J H M. . Ann. Oncol., 2019, 30: 219,

[112] Yang Y, Wang N, Wang Z, Han M, Yan F, Shi Z, Feng S. . Chem. Eng. J., 2023, 474: 145764,

[113] Jiang S, Liu C, He Q, Dang K, Zhang W, Tian Y. . Nano Res., 2023, 16: 9633,

[114] Liu Q, Chen G, Liu X, Tao L, Fan Y, Xia T. . ACS Nano, 2024, 18: 5219

[115] Zhan G, Xua Q, Zhang Z, Wei Z, Yong T, Bie N, Zhang X, Li X, Li J, Gan L, Yang X. . Nanotoday, 2021, 38: 101195,