Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

Abstract

Vascular embolization treatment, a minimally invasive surgery for various blood vessel-related conditions, has emerged as a crucial method in treating such as hemorrhage, arteriovenous malformation, aneurysms, and hypervascular tumors. Liquid embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions, expanding the scope of embolization beyond the reach of solid agents. Recent strides in biomaterials and technologies have spurred the development of novel liquid embolic agents, addressing challenges posed by traditional options. This mini-review provides a concise overview of the recent progress in water-based liquid embolic agents, highlighting their potential to overcome limitations associated with current embolic materials. By presenting selected research outcomes, we illuminate advancements that enhance the efficacy of liquid embolic agents. Furthermore, the review outlines essential properties for effective liquid embolic agents, offering insights for future developments in this field.

Keywords

Endovascular treatment / Lquid embolic agent / Hydrogel

References

[1] Hu J, Albadawi H, Chong B W, Deipolyi A R, Sheth R A, Khademhosseini A, Oklu R. Adv. Mater., 2019, 31: 1901071.

[2] Altman R, Ferreira R, Barragan C, Bhojani N, Lajkosz K, Zorn K C, Chughtai B, Annamalai G, Elterman D S. BMC Urol., 2024, 24: 22.

[3] Szmygin P, Szmygin M, Roman T, Jargietto T, Rola R. Neurol. Neurochir Pol., 2023, 57: 305.

[4] Qi Y, Liu H, Jia J, Li J, Liu A, Jiang C. Clin. Neurol. Neurosurg., 2020, 195: 105882.

[5] Li Z, Di C, Li S, Yang X, Nie G. Acc. Chem. Res., 2019, 52: 2703.

[6] Bruno C A Jr., Meyers P M. Interv. Neurol., 2013, 1: 109.

[7] Schimmel K, Ali M K, Tan S Y, Teng J, Do H M, Steinberg G K, Stevenson D A, Spiekerkoetter E. Int. J. Mol. Sci., 2021, 22: 9037.

[8] Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H. J. Cereb. Blood Flow Metab., 2021, 41: 3141.

[9] Qi Y, Sun Y, Wang Y, Jia J, Zhong H, Yang H, Lv M, Liu H. BioMed Res. Int., 2021, 2021: 9976541.

[10] Liu H., Li C., Ren S., Li T., Zhong H., Jia J., Yang H., Qi Y., Feng J., Li Y., Wang Y., Stroke Vasc. Neurol., 2023, doi: https://doi.org/10.1136/svn-2022-002260.

[11] Wang C Y, Hu J, Sheth R A, Oklu R. Prog. Biomed. Eng., 2020, 2: 012003.

[12] Leyon J J, Littlehales T, Rangarajan B, Hoey E T, Ganeshan A. Curr. Probl. Diagn. Radiol., 2014, 43: 35.

[13] Qi Y, Xu T, Jiang C, Wang Y, Liu H. Neurosurg. Rev., 2022, 45: 1513.

[14] Ko G, Choi J W, Lee N, Kim D, Hyeon T, Kim H-C. Biomaterials, 2022, 287: 121634.

[15] Piacentino F, Fontana F, Curti M, Macchi E, Coppola A, Ossola C, Giorgianni A, Marra P, Mosconi C, Ierardi A M, Basile A, Golfieri R, Carrafiello G, Carcano G, Venturini M. J. Clin. Med., 2021, 10: 4841.

[16] Jiang Y, Zhang Y, Lu Z, Wang X, Bai S, Chen Y, Mao J, Liu G. ChemPhysMater, 2022, 1: 39.

[17] Jin Z P, Fan H L, Osanai T, Nonoyama T, Kurokawa T, Hyodoh H, Matoba K, Takeuchi A, Gong J P, Fujimura M. Proc. Natl. Acad. Sci. USA, 2022, 119: e2206685119.

[18] Fan L, Duan M, Xie Z, Pan K, Wang X, Sun X, Wang Q, Rao W, Liu J. Small, 2020, 16: 1903421.

[19] Poursaid A, Jensen M M, Huo E, Ghandehari H. J. Controlled Release, 201, 240: 414.

[20] Lord J, Britton H, Spain S G, Lewis A L. J. Mater. Chem. B, 2020, 8: 8207.

[21] Pal A, Blanzy J, Gómez K J R, Preul M C, Vernon B L. Gels, 2023, 9: 378.

[22] Li X, Ullah M W, Li B, Chen H. Adv. Healthcare Mater., 2023, 12: 2202787.

[23] Froberg L, Helgstrand F, Clausen C, Steinmetz J, Eckardt H. J. Emerg. Trauma Shock, 201, 9: 107.

[24] Sasaki K, Okada T, Yamaguchi M, Ahmed M, Gentsu T, Ueshima E, Sofue K, Tanimura K, Yamada H, Sugimoto K, Murakami T. Emerg. Radiol., 2021, 28: 1127.

[25] Eriksson L-G, Ljungdahl M, Sundbom M, Nyman R. J. Vasc. Interv. Radiol., 2008, 19: 1413.

[26] Fang Y, Han X, Liu L, Lou W. Int. Surg. J., 2018, 51: 223.

[27] Hickman D A, Pawlowski C L, Sekhon U D S, Marks J, Gupta A S. Adv. Mater., 2018, 30: 1700859.

[28] Lawton M T, Rutledge W C, Kim H, Stapf C, Whitehead K J, Li D Y, Krings T, terBrugge K, Kondziolka D, Morgan M K, Moon K, Spetzler R F. Nat. Rev. Dis. Primers, 2015, 1: 15008.

[29] Kumar A, Mittal M, Srivastava D, Jaetli V, Chaudhary S. Contemp. Clin. Dent., 2017, 8: 482.

[30] Behravesh S, Yakes W, Gupta N, Naidu S, Chong B W, Khademhosseini A, Oklu R. Cardiovasc. Diagn. Ther., 201, 6: 557.

[31] Nassiri N, Cirillo-Penn N C, Thomas J. J. Vasc. Surg., 2015, 62: 1667.

[32] Zhao B, Fan Y, Xiong Y, Yin R, Zheng K, Li Z, Tan X, Yang H, Zhong M. J. Neurol. Sci., 201, 371: 62.

[33] Molyneux A J, Kerr R S C, Yu L-M, Clarke M, Sneade M, Yarnold J A, Sandercock P. Lancet, 2005, 366: 809.

[34] Loffroy R, Guiu B, Cercueil J-P, Krause D. Curr. Vasc. Pharmacol., 2009, 7: 250.

[35] Osuga K, Maeda N, Higashihara H, Hori S, Nakazawa T, Tanaka K, Nakamura M, Kishimoto K, Ono Y, Tomiyama N. Int. J. Clin. Oncol., 2012, 17: 306.

[36] Wu B, Zhou J, Ling G, Zhu D, Long Q. World J. Surg. Oncol., 2018, 16: 69.

[37] Dubbelboer I R, Sjögren E, Lennernäs H. AAPS J., 2018, 20: 96.

[38] Ravina J H, Ciraru-Vigneron N, Bouret J M, Herbreteau D, Houdart E, Aymard A, Merland J J. Lancet, 1995, 346: 671.

[39] Pisco J M, Bilhim T, Pinheiro L C, Fernandes L, Pereira J, Costa N V, Duarte M, Oliveira A G. J. Vasc. Interv. Radiol., 201, 27: 1115.

[40] Malling B, Røder M A, Brasso K, Forman J, Taudorf M, Lönn L. Eur. Radiol., 2019, 29: 287.

[41] Hu X-E, Shi Y-R, Zhu X, Tian K-W, Xu X-L. J. Drug Delivery Sci. Technol., 2023, 80: 104107.

[42] Lee B H, West B, McLemore R, Pauken C, Vernon B L. Biomacromolecules, 200, 7: 2059.

[43] Shi X, Gao H, Dai F, Feng X, Liu W. Biomater. Sci., 201, 4: 1673.

[44] Li H, Qian K, Zhang H, Li L, Yan L, Geng S, Zhao H, Zhang H, Xiong B, Li Z, Zheng C, Zhao Y, Yang X. Chem. Eng. J., 2021, 418: 129534.

[45] Li X, Liu W, Ye G, Zhang B, Zhu D, Yao K, Liu Z, Sheng X. Biomaterials, 2005, 26: 7002.

[46] Xie W, Li H, Yu H, Zhou H, Guo A, Yao Q, Zhang L, Zhao Y, Tian H, Li L. Nanoscale, 2023, 15: 1835.

[47] Li L, Cao Y, Zhang H, Zheng M, Xing J, Zheng C, Zhao Y, Yang X. J. Nanobiotechnol., 2023, 21: 413.

[48] Zhou H, Xie W, Guo A, Chen B, Hu S, Zheng M, Yu H, Tian H, Li L. Des. Monomers Polym., 2023, 26: 31.

[49] Zhao H, Zheng C, Feng G, Zhao Y, Liang H, Wu H, Zhou G, Liang B, Wang Y, Xia X. AJNR Am. J. Neuroradiol., 2013, 34: 169.

[50] Zhao Y, Zheng C, Wang Q, Fang J, Zhou G, Zhao H, Yang Y, Xu H, Feng G, Yang X. Adv. Funct. Mater., 2011, 21: 2035.

[51] Li H, Sun H, Liu Y, Yuan B, Hu J, Jiang Y, Li Q, Cao S, Liu H, Xiao B, Shi P, Yang X, Wang S, Zhao Y. Environ. Sci.: Nano, 2023, 10: 3357.

[52] Bearat H H, Preul M C, Vernon B L. J. Biomed. Mater. Res., Part A, 2013, 101A: 2515.

[53] Huang W, Rollett A, Kaplan D L. Expert Opin. Drug Delivery, 2015, 12: 779.

[54] Cappello J, Crissman J W, Crissman M, Ferrari F A, Textor G, Wallis O, Whitledge J R, Zhou X, Burman D, Aukerman L, Stedronsky E R. J. Controlled Release, 1998, 53: 105.

[55] Poursaid A, Price R, Tiede A, Olson E, Huo E, McGill L, Ghandehari H, Cappello J. Biomaterials, 2015, 57: 142.

[56] Poursaid A, Jensen M M, Nourbakhsh I, Weisenberger M, Hellgeth J W, Sampath S, Cappello J, Ghandehari H. Mol. Pharmaceutics, 201, 13: 2736.

[57] Dumortier G, Grossiord J L, Agnely F, Chaumeil J C. Pharm. Res., 200, 23: 2709.

[58] Russo E, Villa C. Pharmaceutics, 2019, 11: 671.

[59] Raymond J, Metcalfe A, Salazkin I, Schwarz A. Biomaterials, 2004, 25: 3983.

[60] San Norberto E M, Taylor J H, Carrera S, Vaquero C. J. Vasc. Surg., 2012, 56: 1782.

[61] Huang L, Shen M, Li R, Zhang X, Sun Y, Gao P, Fu H, Liu H, He Y, Du Y, Cao J, Duan Y. Oncotarget, 201, 7: 73280.

[62] Yang H, Lei K, Zhou F, Yang X, An Q, Zhu W, Yu L, Ding J. Mater. Sci. Eng. C, 2019, 102: 606.

[63] Kang S I, Na K, Bae Y H. Macromol. Symp., 2001, 172: 149.

[64] Han S K, Na K, Bae Y H. Colloids Surf. A, 2003, 214: 49.

[65] Shim W S, Yoo J S, Bae Y H, Lee D S. Biomacromolecules, 2005, 6: 2930.

[66] Lym J S, Nguyen Q V, Ahn D W, Huynh C T, Jae H J, Kim Y I, Lee D S. Acta Biomater., 201, 41: 253.

[67] Nguyen Q V, Lee M S, Lym J S, Kim Y I, Jae H J, Lee D S. J. Mater. Chem. B, 201, 4: 6524.

[68] Nguyen Q V, Lym J S, Huynh C T, Kim B S, Jae H J, Kim Y I, Lee D S. Polym. Chem., 201, 7: 5805.

[69] Huynh C T, Nguyen M K, Kim J H, Kang S W, Kim B S, Lee D S. Soft Matter, 2011, 7: 4974.

[70] Huynh C T, Nguyen Q V, Lym J S, Kim B S, Huynh D P, Jae H J, Kim Y I, Lee D S. RSC Adv., 201, 6: 47687.

[71] Lu D, Wang J, Li Y, Zhang Y, Yu L, Xu T, Guo H, Zhang Y, Wang X, Wang X, Teng G, Lei Z. ACS Cent. Sci., 2020, 6: 1977.

[72] Fries F, Tomori T, Schulz-Schaeffer W J, Jones J, Yilmaz U, Kettner M, Simgen A, Reith W, Mühl-Benninghaus R. J. Neurointerv. Surg., 2022, 14: 286.

[73] Jones J P, Sima M, O’Hara R G, Stewart R J. Adv. Healthcare Mater., 201, 5: 795.

[74] Avery R K, Albadawi H, Akbari M, Zhang Y S, Duggan M J, Sahani D V, Olsen B D, Khademhosseini A, Oklu R. Sci. Transl. Med., 201, 8: 365ra156.

[75] Smith S A, Travers R J, Morrissey J H. Crit. Rev. Biochem. Mol. Biol., 2015, 50: 326.

[76] Fan H L, Guo H L, Wang J H, Gong J P. Giant, 2020, 1: 100005.

[77] Israelachvili J. N., London: Elsevier. 3rd edition, 2010.

[78] Fan H L, Wang J H, Tao Z, Huang J C, Rao P, Kurokawa T, Gong J P. Nat. Commun., 2019, 10: 5127.

[79] Fan H L, Cai Y R, Gong J P. Sci. China: Chem., 2021, 64: 1560.