Nanotechnology-based Detection Strategies for Hypertension Biomarkers

Abstract

Hypertension significantly increases the risk of cardiovascular diseases and seriously affects people’s health. The incidence of hypertension is rising rapidly in the world and hypertension has become a significant factor influencing the global average life expectancy. The diagnosis of hypertension is generally fulfilled by measuring diastolic and systolic blood pressure, but it is insufficient to differentiate essential hypertension from secondary hypertension, so it is crucial to identifying the cause of hypertension by detecting biomarkers in plasma. In clinical practice, five plasma biomarkers are utilized for diagnosing hypertension, and the detection tasks of a large number of cases have raised increasing demands for cost-effective, efficient, speedy, and diverse methods, which makes many traditional diagnostic technologies inadequate for meeting the needs of clinical diagnosis. The nanomaterial-based detection techniques have frequently attained the qualities of quick reaction, low cost, straightforward operation, high sensitivity, and strong specificity in recent years with the advancement of nanotechnology, so they have great potential for early and rapid diagnosis. In this review, we will introduce the characteristics and drawbacks of current clinical detection methods for hypertension screening, the principles and advancements of nanotechnology-based detection methods, as well as their potentials for clinical application.

Keywords

Hypertension / Biomarker / Diagnosis / Clinical detection / Nanotechnology-based detection

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