A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

Abstract

Cancer is a leading cause of death worldwide, and a series of strategies has been reported for tumor-specific therapy. Currently, chemodynamic therapy (CDT) has become a research hotspot for antitumor treatment due to its advantages of high specificity, endogenous stimulation, and high biosafety. However, the therapeutic effects of CDT are normally limited in the complex tumor microenvironment (TME), such as insufficient acidity, tumor hypoxia, low hydrogen peroxide (H₂O₂), and high glutathione (GSH). Consequently, different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions, which provided more opportunities to improve the efficiency of CDT. This review focuses on nanomaterial-based strategies for enhancing CDT through manipulating TME. Upon CDT enhancements, this review would provide a reference for the future development of efficient CDT nanomaterials.

Keywords

Chemodynamic therapy / Tumor microenvironment / Nanomaterial / Manipulating strategy / Fenton/Fenton-like reaction

References

[1] Sung H, Ferlay J, Siegel R L, Laversanne M, Soerjomataram I, Jemal A, Bray F. CA Cancer J. Clin., 2021, 71: 209.

[2] Bray F, Ferlay J, Soerjomataram I, Siegel R L, Torre L A, Jemal A. CA Cancer J. Clin., 2018, 68: 394.

[3] Gotwals P, Cameron S, Cipolletta D, Cremasco V, Crystal A, Hewes B, Mueller B, Quaratino S, Sabatos-Peyton C, Petruzzelli L, Engelman J A, Dranoff G. Nat. Rev. Cancer, 2017, 17: 286.

[4] Huang Q, Liu X, Zhang P, Wu Z, Zhao Z. Chem. Res. Chinese Universities, 2022, 38(4): 928.

[5] Guo X, Gao C, Yang D-H, Li S. Drug Resis. Update, 2023, 67: 100937.

[6] Harper E, Talbot C J. Clin. Oncol., 2019, 31: 326.

[7] Valastyan S, Weinberg Robert A. Cell, 2011, 147: 275.

[8] Dai Y, Xu C, Sun X, Chen X. Chem. Soc. Rev., 2017, 46: 3830.

[9] de Visser K E, Joyce J A. Cancer Cell, 2023, 41: 374.

[10] Ji C, Li H, Zhang L, Wang P, Lv Y, Sun Z, Tan J, Yuan Q, Tan W. Angew. Chem. Int. Ed., 2022, 61: e202200237.

[11] Liu J, Zhang C, Rees T W, Ke L, Ji L, Chao H. Coord. Chem. Rev., 2018, 363: 17.

[12] Liang L, Tang Y, Hu X, Wang J, Xiao S, Li D, Fu L, Li Z, Yuan Q. CCS Chem., 2019, 1: 490.

[13] Wang Y, Wang D, Zhang Y, Xu H, Shen L, Cheng J, Xu X, Tan H, Chen X, Li J. Bioact. Mater., 2023, 22: 239.

[14] Yamaguchi T, Kitahara S, Kusuda K, Okamoto J, Horise Y, Masamune K, Muragaki Y. Cancers (Basel), 2021, 13: 6184.

[15] Lu Z, Zhou L, Yao Y, Li F, Hong Z, Wu Y, Li X. Adv. Funct. Mater., 2023, 33: 2214749.

[16] Fenton H J H. J. Chem. Soc., Trans., 1894, 65: 899.

[17] Yan Q, Lian C, Huang K, Liang L, Yu H, Yin P, Zhang J, Xing M. Angew. Chem. Int. Ed., 2021, 60: 17155.

[18] Zhang C, Bu W, Ni D, Zhang S, Li Q, Yao Z, Zhang J, Yao H, Wang Z, Shi J. Angew. Chem. Int. Ed., 201, 55: 2101.

[19] Jia C, Guo Y, Wu F-G. Small, 2022, 18: 2103868.

[20] Lin H, Chen Y, Shi J. Chem. Soc. Rev., 2018, 47: 1938.

[21] Tran S, DeGiovanni P-J, Piel B, Rai P. Clin. Transl. Med., 2017, 6: 44.

[22] Shen X, Xu W, Ouyang J, Na N. Chin. Chem. Lett., 2022, 33: 4505.

[23] Moghimi S M, Hunter A C, Murray J C. Faseb J., 2005, 19: 311.

[24] Li S-L, Jiang P, Jiang F-L, Liu Y. Adv. Funct. Mater., 2021, 31: 2100243.

[25] Di X, Pei Z, Pei Y, James T D. Coord. Chem. Rev., 2023, 484: 215098.

[26] Zhang Z, Ding C, Sun T, Wang L, Chen C. Adv. Healthc. Mater., 2023, 12: 2300153.

[27] Li X, Luo R, Liang X, Wu Q, Gong C. Chin. Chem. Lett., 2022, 33: 2213.

[28] Tang Z, Zhao P, Wang H, Liu Y, Bu W. Chem. Rev., 2021, 121: 1981.

[29] Wang X-Q, Wang W, Peng M, Zhang X-Z. Biomaterials, 2021, 266: 120474.

[30] Lu H-F, Chen H-F, Kao C-L, Chao I, Chen H-Y. PCCP, 2018, 20: 22890.

[31] Chen W, Liu J, Zheng C, Bai Q, Gao Q, Zhang Y, Dong K, Lu T. Int. J. Nanomed., 2022, 17: 2611.

[32] Abeyrathna N, Liao Y. J. Am. Chem. Soc., 2015, 137: 11282.

[33] Chen X, Chen Y, Wang C, Jiang Y, Chu X, Wu F, Wu Y, Cai X, Cao Y, Liu Y, Bu W. Angew. Chem. Int. Ed., 2021, 60: 21905.

[34] Bao W, Liu M, Meng J, Liu S, Wang S, Jia R, Wang Y, Ma G, Wei W, Tian Z. Nat. Commun., 2021, 12: 6399.

[35] Fu L-H, Qi C, Hu Y-R, Lin J, Huang P. Adv. Mater., 2019, 31: 1808325.

[36] Fu L-H, Hu Y-R, Qi C, He T, Jiang S, Jiang C, He J, Qu J, Lin J, Huang P. ACS Nano, 2019, 13: 13985.

[37] Zhang Y, Wan Y, Liao Y, Hu Y, Jiang T, He T, Bi W, Lin J, Gong P, Tang L, Huang P. Sci. Bull., 2020, 65: 564.

[38] Dong S, Dong Y, Jia T, Zhang F, Wang Z, Feng L, Sun Q, Gai S, Yang P. Chem. Mater., 2020, 32: 9868.

[39] Chu Q, Zhu H, Liu B, Cao G, Fang C, Wu Y, Li X, Han G. J. Mat. Chem. B, 2020, 8: 8546.

[40] Lebelo M T, Joubert A M, Visagie M H. Arch. Pharmacal Res., 2019, 42: 833.

[41] Calori I R, Piva H L, Tedesco A C. J. Drug Deliv. Sci. Technol., 2020, 57: 101633.

[42] Meng Q, Tan J, Tong W, Chen C, Liu Z, Liu S, Wang M, Cheng Z, Ding B, Ma P A, Lin J. Chem. Eng. J., 2023, 471: 144563.

[43] Shi L, Wang Y, Zhang C, Zhao Y, Lu C, Yin B, Yang Y, Gong X, Teng L, Liu Y, Zhang X, Song G. Angew. Chem. Int. Ed., 2021, 60: 9562.

[44] Becker H M. Br. J. Cancer, 2020, 122: 157.

[45] Chen X, Zhang H, Zhang M, Zhao P, Song R, Gong T, Liu Y, He X, Zhao K, Bu W. Adv. Funct. Mater., 2020, 30: 1908365.

[46] Zhang L, Wan S-S, Li C-X, Xu L, Cheng H, Zhang X-Z. Nano Lett., 2018, 18: 7609.

[47] Fang C, Deng Z, Cao G, Chu Q, Wu Y, Li X, Peng X, Han G. Adv. Funct. Mater., 2020, 30: 1910085.

[48] Jiang S, Chen X, Lin J, Huang P. Adv. Mater., 2023, 35: 2207951.

[49] Tian F, Wang S, Shi K, Zhong X, Gu Y, Fan Y, Zhang Y, Yang M. Adv. Sci., 2021, 8: 2102595.

[50] Xiao J, Zhang G, Xu R, Chen H, Wang H, Tian G, Wang B, Yang C, Bai G, Zhang Z, Yang H, Zhong K, Zou D, Wu Z. Biomaterials, 2019, 216: 119254.

[51] Zhu J, Cui Q, Wen W, Zhang X, Wang S. Chem. Res. Chinese Universities, 2022, 38(4): 919.

[52] Jiang C, He T, Tang Q, He J, Ren Q, Zhang D-Y, Gurram B, Blum N T, Chen Y, Huang P, Lin J. Appl. Mater. Today, 2022, 26: 101357.

[53] Ding Y, Xu H, Xu C, Tong Z, Zhang S, Bai Y, Chen Y, Xu Q, Zhou L, Ding H, Sun Z, Yan S, Mao Z, Wang W. Adv. Sci., 2020, 7: 2001060.

[54] Zhao Q, Zheng L, Gao Y, Li J, Wei J, Zhang M, Sun J, Ouyang J, Na N. J. Am. Chem. Soc., 2023, 145: 12586.

[55] Chu Z, Yang J, Zheng W, Sun J, Wang W, Qian H. Coord. Chem. Rev., 2023, 481: 215049.

[56] Mallepally R R, Parrish C C, McHugh M A M, Ward K R. Int. J. Pharm., 2014, 475: 130.

[57] Song X, Xu J, Liang C, Chao Y, Jin Q, Wang C, Chen M, Liu Z. Nano Lett., 2018, 18: 6360.

[58] Rosli N R A M, Mohamed F, Heng C K, Rahman I A, Ahmad A F, Mohamad H M K. AIP Conference Proceedings, 2014, 1614: 78.

[59] Li J, Wei K, Zuo S, Xu Y, Zha Z, Ke W, Chen H, Ge Z. Adv. Funct. Mater., 2017, 27: 1702108.

[60] Li W-P, Su C-H, Chang Y-C, Lin Y-J, Yeh C-S. ACS Nano, 201, 10: 2017.

[61] Liu Y, Zhang J, Du J, Song K, Liu J, Wang X, Li B, Ouyang R, Miao Y, Sun Y, Li Y. Acta Biomater., 2021, 129: 280.

[62] Hu H, Yu L, Qian X, Chen Y, Chen B, Li Y. Adv. Sci., 2021, 8: 2000494.

[63] Tang Z-M, Liu Y-Y, Ni D-L, Zhou J-J, Zhang M, Zhao P-R, Lv B, Wang H, Jin D-Y, Bu W-B. Adv. Mater., 2020, 32: 1904011.

[64] Feng X, Lin T, Chen D, Li Z, Yang Q, Tian H, Xiao Y, Lin M, Liang M, Guo W, Zhao P, Guo Z. Acta Biomater., 2023, 160: 211.

[65] Shen J, Yu H, Shu Y, Ma M, Chen H. Adv. Funct. Mater., 2021, 31: 2106106.

[66] Deng H, Yang Z, Pang X, Zhao C, Tian J, Wang Z, Chen X. Nano Today, 2022, 42: 101337.

[67] Tang Z, Wu S, Zhao P, Wang H, Ni D, Li H, Jiang X, Wu Y, Meng Y, Yao Z, Cai W, Bu W. Adv. Sci., 2022, 9: 2201232.

[68] Ueda M, Kinoshita H, Yoshida T, Kamasawa N, Osumi M, Tanaka A. FEMS Microbiol. Lett., 2003, 219: 93.

[69] Liu Y, Zhai S, Jiang X, Liu Y, Wang K, Wang C, Zhang M, Liu X, Bu W. Adv. Funct. Mater., 2021, 31: 2010390.

[70] Yu Y, Huang Z, Chen Q, Zhang Z, Jiang H, Gu R, Ding Y, Hu Y. Biomaterials, 2022, 288: 121724.

[71] Dong Z, Feng L, Chao Y, Hao Y, Chen M, Gong F, Han X, Zhang R, Cheng L, Liu Z. Nano Lett., 2019, 19: 805.

[72] Huang Y, Wu S, Zhang L, Deng Q, Ren J, Qu X. ACS Nano, 2022, 16: 4228.

[73] Chen Q, Zhou J, Chen Z, Luo Q, Xu J, Song G. ACS Appl. Mater. Interfaces, 2019, 11: 30551.

[74] Huang Y, Jiang Y, Xiao Z, Shen Y, Huang L, Xu X, Wei G, Xu C, Zhao C. Chem. Eng. J., 2020, 380: 122369.

[75] Lin L-S, Song J, Song L, Ke K, Liu Y, Zhou Z, Shen Z, Li J, Yang Z, Tang W, Niu G, Yang H-H, Chen X. Angew. Chem. Int. Ed., 2018, 57: 4902.

[76] Wang Z, Fu L, Zhu Y, Wang S, Shen G, Jin L, Liang R. J. Mat. Chem. B, 2021, 9: 710.

[77] Ma Y, Su Z, Zhou L, He L, Hou Z, Zou J, Cai Y, Chang D, Xie J, Zhu C, Fan W, Chen X, Ju S. Adv. Mater., 2022, 34: 2107560.

[78] Chen T, Hou P, Zhang Y, Ao R, Su L, Jiang Y, Zhang Y, Cai H, Wang J, Chen Q, Song J, Lin L, Yang H, Chen X. Angew. Chem. Int. Ed., 2021, 60: 15006.

[79] Zheng R, Cheng Y, Qi F, Wu Y, Han X, Yan J, Zhang H. Adv. Healthc. Mater., 2021, 10: 2100412.

[80] Szabo C, Coletta C, Chao C, Módis K, Szczesny B, Papapetropoulos A, Hellmich M R. Proc. Natl. Acad. Sci., 2013, 110: 12474.

[81] Wu Y C, Wang X J, Yu L, Chan F K L, Cheng A S L, Yu J, Sung J J Y, Wu W K K, Cho C H. PLoS One, 2012, 7: e37572.

[82] An L, Wang X, Rui X, Lin J, Yang H, Tian Q, Tao C, Yang S. Angew. Chem. Int. Ed., 2018, 57: 15782.

[83] Liu D, Liu M, Wan Y, Zhou X, Yang S, An L, Huang G, Tian Q. Chem. Eng. J., 2021, 422: 130098.

[84] He T, Jiang C, He J, Zhang Y, He G, Wu J, Lin J, Zhou X, Huang P. Adv. Mater., 2021, 33: 2008540.

[85] Tian H, Zhang M, Jin G, Jiang Y, Luan Y. J. Colloid Interface Sci., 2021, 587: 358.

[86] Wang X, Wang X, Zhong X, Li G, Yang Z, Gong Y, Liu Z, Cheng L. Appl. Phys. Rev., 2020, 7: 041411.

[87] Chen T, Huang R, Liang J, Zhou B, Guo X-L, Shen X-C, Jiang B-P. Chem.-Eur. J., 2020, 26: 15159.

[88] Huo M, Wang L, Wang Y, Chen Y, Shi J. ACS Nano, 2019, 13: 2643.

[89] Wang Y, An L, Lin J, Tian Q, Yang S. Chem. Eng. J., 2020, 385: 123925.

[90] Zhang K, Meng X, Yang Z, Dong H, Zhang X. Biomaterials, 2020, 258: 120278.

[91] Yan Y, Hou Y, Zhang H, Gao W, Han R, Yu J, Xu L, Tang K. Colloids Surf. B. Biointerfaces, 2021, 208: 112103.

[92] Bindra A K, Wang D, Zheng Z, Jana D, Zhou W, Yan S, Wu H, Zheng Y, Zhao Y. Biomaterials, 2021, 279: 121188.

[93] Li Y, Jia R, Lin H, Sun X, Qu F. Adv. Funct. Mater., 2021, 31: 2008420.

[94] Mi W, Tang S, Guo S, Li H, Shao N. Chin. Chem. Lett., 2022, 33: 1331.

[95] Feng L, Gai S, He F, Yang P, Zhao Y. ACS Nano, 2020, 14: 7245.

[96] Chen M, Zhao S, Zhu J, Feng E, Lv F, Chen W, Lv S, Wu Y, Peng X, Song F. ACS Appl. Mater. Interfaces, 2022, 14: 20682.

[97] Zhang S, Cao C, Lv X, Dai H, Zhong Z, Liang C, Wang W, Huang W, Song X, Dong X. Chem. Sci., 2020, 11: 1926.

[98] Song Y, Sun Y, Tang M, Yue Z, Ni J, Zhao J, Wang W, Sun T, Shi L, Wang L. ACS Appl. Mater. Interfaces, 2022, 14: 4914.

[99] Ma X, Wang Y, Liu X-L, Ma H, Li G, Li Y, Gao F, Peng M, Fan H M, Liang X-J. Nanoscale Horiz., 2019, 4: 1450.

[100] Li Y, Yang J, Gu G, Guo X, He C, Sun J, Zou H, Wang H, Liu S, Li X, Zhang S, Wang K, Yang L, Jiang Y, Wu L, Sun X. Nano Lett., 2022, 22: 963.

[101] Fan Z, Jiang B, Zhu Q, Xiang S, Tu L, Yang Y, Zhao Q, Huang D, Han J, Su G, Ge D, Hou Z. ACS Appl. Mater. Interfaces, 2020, 12: 14884.

[102] Li J, Wei J, Gao Y, Zhao Q, Sun J, Ouyang J, Na N. Chin. Chem. Lett., 2023, 34: 107662.

[103] Liu C-G, Tang H-X, Zheng X, Yang D-Y, Zhang Y, Zhang J-T, Kankala R K, Wang S-B, Liu G, Chen A-Z. ACS Appl. Mater. Interfaces, 2020, 12: 40673.

[104] Xin C, Zhang Y, Bao M, Yu C, Hou K, Wang Z. J. Colloid Interface Sci., 2022, 606: 1488.

[105] Liu X, Liu M, Chen J, Li Z, Yuan Q. Chin. Chem. Lett., 2018, 29: 1321.

[106] Li J, Hu Z-E, We Y-J, Liu Y-H, Wang N, Yu X-Q. J. Colloid Interface Sci., 2022, 606: 1219.

[107] Tang W, Gao H, Ni D, Wang Q, Gu B, He X, Peng W. J. Nanobiotechnol., 2019, 17: 68.

[108] Yang Z, Wang P, Liu X, Liu X, Shen Y, Xie A, Zhu M. Mater. Today Nano, 2022, 20: 100258.