Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

Abstract

Host-guest inclusion complexes have been extensively studied for drug delivery applications. The host molecule, typically cyclodextrin, creates a cavity, in which the guest molecule, such as a drug, can be encapsulated. This encapsulation can protect the drug from degradation, improve its solubility and stability, and enhance its bioavailability. Moreover, host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of action. Various techniques, such as covalent bonding, non-covalent interactions, and self-assembly have been used to form these complexes. Host-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery systems. This mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex, highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.

Keywords

Poor water solubility / Inclusion complex / Physicochemical / Biopharmaceutical

References

[1] Suzuki H, Yakushiji K, Matsunaga S, Yamauchi Y, Seto Y, Sato H, Onoue S. J. Pharm. Sci., 2018, 107: 446.

[2] Chen Y, Li L, Yao J, Ma Y Y, Chen J M, Lu T B. Cryst. Growth Des., 201, 16: 2923.

[3] Sun C C. Expert Opin. Drug Deliv., 2012, 10: 201.

[4] Shan N, Perry M L, Weyna D R, Zaworotko M J. Expert Opin. Drug Metab. Toxicol., 2014, 10: 1255.

[5] Sayed E, Haj-Ahmad R, Ruparelia K, Arshad M, Chang M W, Ahmad Z. AAPS Pharm. SciTech., 2017, 18: 1507.

[6] Abidi S S A, Azim Y, Gupta A K, Pradeep C P. J. Mol. Struct., 2017, 1150: 103.

[7] Yu G C, Yang Z, Fu X, Yung B C, Yang J, Mao Z, Shao L, Hua B, Liu Y, Zhang F, Fan Q. Nat. Commun., 2018, 9: 766.

[8] Ramadhani N M, Shabir C, Conville M. Int. J. Pharm., 2014, 475: 514.

[9] Williams H. D., Trevaskis N. L., Charman S. A., Shanker R. M., Charman W. N., Pouton C. W., Porter C. J. H., Pharmacol. Revi., 2013, 315

[10] Liu X., Zhao L., Wu F., International Journal of Pharmaceutics., 2023, 122704

[11] Pöstges F, Kayser K, Appelhaus J, Monschke M, Gütschow M, Steinebach C, Wagner K G. Pharmaceutics, 2023, 15: 156.

[12] Repka M A, Majumdar S, Battu S K, Srirangam R, Upadhye S B. Drug Deliv., 2008, 5: 1357.

[13] Mooter G V D. Drug Discov., Today Technol., 2012, 9: 79.

[14] Lin X, Hu Y, Liu L, Su, Li N, Yu J, Tang B, Yang Z. Pharm. Res., 2018, 35: 125.

[15] Saha S, Roy A, Roy K, Roy M N. Sci. Rep., 201, 6: 35764.

[16] Inam M, Liu L, Wang J W, Yu K X, Phan C U, Shen J, Zhang W H, Tang G, Hu X. Int. J. Mol. Sci., 2021, 22: 928.

[17] Ketan T. S., Anuradha K. G., Jignasa K. S., Int. Scho. Res. Net., 2012, 195727

[18] Malik N A. Mini Rev. Med. Chem., 2022, 4: 570.

[19] Walker M A. Tactics in Contemporary Drug Des., 2014, 9: 69.

[20] Huang Y, Dai W G. Acta Pharm. Act. B, 2014, 4: 18.

[21] Bai H, Wang J W, Phan CU, Chen Q, Hu X, Zhou J, Lai L, Tang G. Nat. Commun., 2021, 12: 759.

[22] Roy M, Ekka D, Saha S, Roy M C. RSC Adv., 2014, 4: 42383.

[23] Davis M E, Brewster M E. Nat. Rev. Drug Disco., 2004, 3: 1023.

[24] Schluep T, Cheng J J, Khin K T, Davis M E. Cancer Chemother. Pharm., 200, 57: 654.

[25] Cheng J, Khin K T, Davis M E. Mol. Pharm., 2004, 1: 183.

[26] Yu G, Yang Z, Fu X, Yung B C, Yang J, Mao Z, Shao L, Hua B, Liu Y, Zhang F, Fan Q, Wang S, Jacobson O, Jin A, Gao C, Tang X, Huang F, Chen X. Nat. Commun., 2018, 9: 766.

[27] Catchpole O, Mitchell K, Bloor S, Davis P, Suddes A. J. Funct. Food., 2018, 41: 1.

[28] Mazet M, Choisnard L, Levilly D, Wouessidjewe D, Geze A. Pharmaceutics., 2018, 10: 249.

[29] Zimmer S., Alena Grebe A., Bakke S. S., Bode N., Halvorsen B., Ulas T., Skjelland M., Nardo D., Labzin L. I., Kerksiek A., Hempel C., Heneka M. T., Hawxhurst V., Fitzgerald M. L., Trebicka J., Björkhem I., Gustafsson J., Westerterp M., Tall A. R., Wright S. D., Espevik T., Schultze J. L., Nickenig G., Lütjohann D., Latz E., Sci. Transl. Med., 2016, 8

[30] Liu S M, Cogny A, Kockx M, Dean R T, Gaus K, Jessup W, Kritharides L. J. Lipid Res., 2003, 44: 1156.

[31] Abdul S K, Abu Bakar M R, Jamal P, Adam F. J. Chem. Eng. Data., 2013, 58: 3447.

[32] Sida D, Baitichea M, Elbahrib Z, Djerbouaa F, Boutahalac M, Bouaziz Z, Le Borgne M. J. Enzyme Inhib. Med. Chem., 2021, 36: 605.

[33] Chadha V S, Bhat K M. J. Indian Soc. Periodontol., 2012, 16: 200.

[34] Guimaräes P P G, Menezes A C D, Teixeira K I R, Denadai  M L, Fills R A, Cortés M E, Sinisterra R D. J. Incl. Phenom. Macrocycl. Chem., 2021, 99: 197.

[35] Periasamy R, Kothainayaki S, Sivakumar K. J. Mol. Struc., 2021, 1224: 129050.

[36] Caldarola G, Infusino S, Divella R, Ferraro E, Mazzocca A, Rose F D, Filippelli G, Abbate I, Brandi M. Future Oncol., 2015, 11: 1863.

[37] Wang F, Bank T, Malnassy G, Arteaga M, Shang N, Dalheim A, Ding X, Cotler S J, Denning M F, Nishimura M I, Breslin P, Qiu W. Hepatol Commun., 2018, 2: 732.

[38] Mao J, Yang H B, Cui T T, Pan P, Kabir N, Chen D, Ma J Y, Chen X Y, Chen Y J, Yang Y. Eur. J. Pharmacol., 2018, 832: 39.

[39] Phan C U, Zheng Z, Wang J W, Wang Q, Hu X, Tang G, Bai H. Biomater. Sci., 2019, 7: 4758.

[40] Semalty M, Panchpuri M, Singh D, Semalty A. Curr. Drug Discov. Technol., 2014, 11: 154.

[41] Connolly K R, Thase M E. Expert. Opin. Pharmacother., 201, 17: 421.

[42] Celada P, Bortolozzi A, Artigas F. CNS Drugs, 2013, 27: 703.

[43] Köhler S, Cierpinsky K, Kronenberg G, Adli M. J. Psycho Pharmacol., 201, 30: 13.

[44] Wesołowska A, Tatarczyńska E, Nikiforuk A, Chojnacka-Wójcik E. Eur. J. Pharmacol., 2007, 555: 43.

[45] Farcas A, Liu Y C, Nilam M, Balan-Porcarasu M, Ursu E L, Nau W M, Hennig A. Eur. Polym. J., 2019, 113: 236.

[46] Guo D S, Uzunova V D, Assaf K I, Lazar A I, Liu Y, Nau W M. Supramol. Chem., 201, 28: 384.

[47] Saffarionpour S, Diosadya L L. Food Funct., 2023, 14: 5062.

[48] Inam M., Phan C. U., Wang J. W., Jamshed M., Hu X., Tang G., J. Chinese Chem. Soc., 2023, 956

[49] Saffarionpour S, Diosady L L. Food Funct., 2023, 14: 5062.

[50] Upadhyay C, D’Souza A, Patel P, Verma V, Upadhayay K K, Bharkatiya M. AAPS PharmSciTech., 2023, 24: 100.

[51] Antonio C S, Rakmai J, Mejuto J C, Jesus S G, Astray G. Food Chem., 2022, 384: 132467.